Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silke Smolders"'
Autor:
Lindsay Poppe, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Zsuzsanna Callaerts-Vegh, Gilles Courtand, Antina de Boer, Silke Smolders, Philip Van Damme, Ludo Van Den Bosch, Rudi D’Hooge, Bart De Strooper, Wim Robberecht, Robin Lemmens
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and
Externí odkaz:
https://doaj.org/article/0285cce7c3524e97916463b91189a49d
Autor:
Laura Rué, Patrick Oeckl, Mieke Timmers, Annette Lenaerts, Jasmijn van der Vos, Silke Smolders, Lindsay Poppe, Antina de Boer, Ludo Van Den Bosch, Philip Van Damme, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto, Wim Robberecht, Robin Lemmens
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brainstem, spinal cord and motor cortex. ALS is characterized by genetic and clinical heterogeneity, suggesting the existence of genet
Externí odkaz:
https://doaj.org/article/7687f003c5824b29951e2494d1c45936
Autor:
Lindsay Poppe, Silke Smolders, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Lies Schoonaert, Antina de Boer, Philip Van Damme, Ludo Van Den Bosch, Wim Robberecht, Robin Lemmens
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a genetic modifier of amyotrophic lateral sclerosis (ALS) in both zebrafish and rodent models, via mod
Externí odkaz:
https://doaj.org/article/c4eef57802cd4256aec80742c79d45db
Autor:
Maricel Gomez-Soler, Lindsay Poppe, Robin Lemmens, Elena B. Pasquale, Silke Smolders, Antina de Boer, Wim Robberecht, Annet Storm, Laura Rué
Publikováno v:
Human Molecular Genetics
Worldwide, stroke is the main cause of long-term adult disability. After the initial insult, most patients undergo a subacute period with intense plasticity and rapid functional improvements. This period is followed by a chronic phase where recovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc8e535a785d511847084d39dc23678
https://doi.org/10.1093/hmg/ddz288
https://doi.org/10.1093/hmg/ddz288
Autor:
Mieke Timmers, Silke Smolders, Bart De Strooper, Annette Lenaerts, Annet Storm, Laura Rué, Wim Robberecht, Robin Lemmens, Lindsay Poppe, Philip Van Damme, Ludo Van Den Bosch, Gilles Courtand, Antina de Boer, Zsuzsanna Callaerts-Vegh, Rudi D'Hooge
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Background EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and the prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011f9c03e5504e84a1847641f50473c1
https://lirias.kuleuven.be/handle/123456789/646258
https://lirias.kuleuven.be/handle/123456789/646258
Autor:
Antina de Boer, Annette Lenaerts, Silke Smolders, Philip Van Damme, Laura Rué, Ludo Van Den Bosch, Robin Lemmens, Mieke Timmers, Lindsay Poppe, Wim Robberecht
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons resulting in severe neurological symptoms. Previous findings of our lab suggested that the axonal guidance tyrosine-kinase receptor EphA4 is an ALS disease-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d775e91e704e3d90c7a5c6672e33459
https://lirias.kuleuven.be/handle/123456789/644294
https://lirias.kuleuven.be/handle/123456789/644294
Autor:
Albert C. Ludolph, Jochen H. Weishaupt, Philip Van Damme, Annette Lenaerts, Wim Robberecht, Jasmijn van der Vos, Silke Smolders, Laura Rué, Patrick Oeckl, Ludo Van Den Bosch, Antina de Boer, Lindsay Poppe, Mieke Timmers, Robin Lemmens, Markus Otto
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brainstem, spinal cord and motor cortex. ALS is characterized by genetic and clinical heterogeneity, suggesting the existence of genetic factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3999b4f7642b8bc4a85ad649a1c41343
https://lirias.kuleuven.be/handle/123456789/644713
https://lirias.kuleuven.be/handle/123456789/644713
Publikováno v:
Brain, behavior, and immunity. 73
Activation of the maternal immune system during pregnancy is a well-established risk factor for neuropsychiatric disease in the offspring, yet, the underlying mechanisms leading to altered brain function remain largely undefined. Microglia, the resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49338fae65a21fa2ed99f64e147bac1
https://pubmed.ncbi.nlm.nih.gov/29870753
https://pubmed.ncbi.nlm.nih.gov/29870753
Autor:
Sophie Smolders, Bert Brône, Sofie Kessels, Florent Poulhes, Olivier Zelphati, Silke Smolders, Cédric Sapet
Publikováno v:
Journal of neuroscience methods. 293
Microglia, the resident phagocytic cells of the brain, have recently been the subject of intense investigation given their role in pathology and normal brain physiology. In general, phagocytic cells are hard to transfect with plasmid DNA. The BV2 cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6592105a486b344ed06100059a3fd20
https://pubmed.ncbi.nlm.nih.gov/28970164
https://pubmed.ncbi.nlm.nih.gov/28970164
Autor:
Sophie Marie-Thérèse, Smolders, Nina, Swinnen, Sofie, Kessels, Kaline, Arnauts, Silke, Smolders, Barbara, Le Bras, Jean-Michel, Rigo, Pascal, Legendre, Bert, Brône
Publikováno v:
Glia. 65(7)
Microglia, the immune cells of the central nervous system, take part in brain development and homeostasis. They derive from primitive myeloid progenitors that originate in the yolk sac and colonize the brain mainly through intensive migration. During
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74162f2ee52b71f967524cf1152893c3
https://pubmed.ncbi.nlm.nih.gov/28417486
https://pubmed.ncbi.nlm.nih.gov/28417486