Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silke Otter"'
Autor:
Okka Scholz, Elena Huß, Silke Otter, Diran Herebian, Anna Hamacher, Laura Mariana Levy, Stanimira Hristeva, Miguel Sanz, Haresh Ajani, Alfredo Rodriguez Puentes, Torsten Hoffmann, Jens Hogeback, Anke Unger, Susanne Terheyden, Michelle Reina do Fundo, Bedair Dewidar, Michael Roden, Eckhard Lammert
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101775- (2023)
Objective: Dextromethorphan (DXM) is a commonly used antitussive medication with positive effects in people with type 2 diabetes mellitus, since it increases glucose tolerance and protects pancreatic islets from cell death. However, its use as an ant
Externí odkaz:
https://doaj.org/article/79f80d669fc64506a41eecd5d5b72d9b
Autor:
Martin Kragl, Rajib Schubert, Haiko Karsjens, Silke Otter, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Chunguang Chen, David Alsteens, Oliver Kuss, Stephan Speier, Daniel Eberhard, Daniel J. Müller, Eckhard Lammert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endoc
Externí odkaz:
https://doaj.org/article/3882207bac40498da5c5335ea5cae3b0
Autor:
T Hoffmann, M Sanz, Alena Welters, O Scholz, Nikolaj Klöcker, J Mrugala, Jurij Dolenšek, Silke Otter, Anna B Hamacher, Klemen, Diran Herebian, Angela Koch, Laura Wörmeyer, Viljem Pohorec, A Piechot
Publikováno v:
Präzisionsmedizin – Eine Reise in die Zukunft der Diabetologie www.diabeteskongress.de.
Autor:
Alena Welters, Silke Otter, Angela Koch, Miguel Sanz, Anna B Hamacher, Laura Wörmeyer, Jens Hogeback, Thomas Meissner, Jessica Mrugala, O Scholz, Eckhard Lammert, Andraž Stožer, Viljem Pohorec, Alexander Piechot, Diran Herebian, Ertan Mayatepek, Nikolaj Klöcker, Torsten Hoffmann, Jurij Dolenšek, Maša Skelin Klemen, Daniel Eberhard
Publikováno v:
Cell Chemical Biology. 28:1474-1488.e7
Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabe
Autor:
Silke Otter, Eckhard Lammert, H Diran, Alena Welters, Daniel Eberhard, O Scholz, J Mrugala, Ertan Mayatepek, Thomas Meissner
Publikováno v:
Diabetes – Nicht nur eine Typ-Frage – www.diabeteskongress.de.
Publikováno v:
Diabetologie und Stoffwechsel.
Autor:
Eckhard Lammert, Annelie Fischer, Tim Heise, Alin Stirban, Silke Otter, F. Sievers, Freimut Schliess, Jan Marquard, Stephan Wnendt, Thomas Meissner, Alena Welters
Publikováno v:
Diabetes, obesity and metabolism, 18(1):100-103
Diabetes, Obesity & Metabolism
Diabetes, Obesity & Metabolism
In this clinical trial, we investigated the blood glucose (BG)‐lowering effects of 30, 60 and 90 mg dextromethorphan (DXM) as well as 100 mg sitagliptin alone versus combinations of DXM and sitagliptin during an oral glucose tolerance test (OGTT) i
Autor:
Eckhard Lammert, Silke Otter
Publikováno v:
Trends in endocrinology and metabolism: TEM. 27(3)
Glutamate represents a key excitatory neurotransmitter in the central nervous system, and also modulates the function and viability of endocrine cells in pancreatic islets. In insulin-secreting beta cells, glutamate acts as an intracellular messenger
Autor:
Jan Eglinger, Maša Skelin Klemen, Olaf Kletke, Eckhard Lammert, Daniel Eberhard, Alena Welters, Silke Otter, Martin Köhler, Stephan Wnendt, Nikolaj Klöcker, Annelie Fischer, Jorge Ferrer, Tim Heise, Diran Herebian, Ertan Mayatepek, Thomas Meissner, Lorenzo Piemonti, Andraž Stožer, Freimut Schliess, Martin Kragl, Bernard Thorens, Per Olof Berggren, Marjan Slak Rupnik, Alin Stirban, Jan Marquard
Publikováno v:
Nature Medicine
In the nervous system, NMDA receptors (NMDARs) participate in neurotransmission and modulate the viability of neurons. In contrast, little is known about the role of NMDARs in pancreatic islets and the insulin-secreting beta cells whose functional im
Autor:
Eckhard Lammert, Kay Jeruschke, Silke Otter, Chunguang Chen, Stephan Speier, Oliver Kuss, Martin Kragl, Haiko Karsjens, Daniel Eberhard, Rajib Schubert, Daniel J. Müller, Jürgen Weiss, David Alsteens, Barbara Bartosinska
Publikováno v:
Nature Communications
Nature Communications, 7
Nature Communications, 7:13560
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Vol. 7, no.7, p. 13560 (20 December 2016)
Nat. Commun. 7:13560 (2016)
Nature Communications, 7
Nature Communications, 7:13560
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Vol. 7, no.7, p. 13560 (20 December 2016)
Nat. Commun. 7:13560 (2016)
An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that depletion of integrin-linked kinase (ILK)