Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

Autor: Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan, Cen Xu

Publikováno v: The Journal of Headache and Pain, Vol 20, Iss 1, Pp 1-12 (2019)

Abstract Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these a

Externí odkaz: https://doaj.org/article/15615ca758694061bb99f36019824d7c

Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? [version 2; referees: 1 approved, 2 approved with reservations]

Autor: Daniel Ortuno, Holly J. Carlisle, Silke Miller

Publikováno v: F1000Research, Vol 5 (2016)

A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in Parkinson’s disease, TDP-43 in ALS, and tau in Alzheimer’s disease. Enhancing intracellular c

Externí odkaz: https://doaj.org/article/47204625008242adb51874b9bdb1e7ae

Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation.

Autor: Silke Miller, Sara Rao, Weiya Wang, Hantao Liu, Judy Wang, Narender R Gavva

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107151 (2014)

The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin. TRPM8 ma

Externí odkaz: https://doaj.org/article/bda35a7371e041359f6ffa57a92865c1

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Autor: Licheng Shi, Bryan D. Moyer, Margarida Martins-Oliveira, Hong Sun, Sonya G. Lehto, Peter J. Goadsby, Simon Akerman, Jan Hoffmann, Dawn Zhu, Weera Supronsinchai, Ruoyuan Yin, Cen Xu, Silke Miller, Judy Wang, Hantao Liu

Publikováno v: Hoffmann, J R, Miller, S, Martins-Oliveira, M, Akerman, S, Supronsinchai, W, Sun, H, Shi, L, Wang, J, Zhu, D, Lehto, S, Liu, H, Yin, R, Moyer, B D, Xu, C & Goadsby, P 2020, ' PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? ', Pain, vol. 161, no. 7, pp. 1670-1681 . https://doi.org/10.1097/j.pain.0000000000001858
Pain

PAC1 receptor blockade using a monoclonal antibody inhibits nociceptive neuronal activity in the trigeminocervical complex.
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0f35bc013beddca80233ef15c9e0b8
https://doi.org/10.1097/j.pain.0000000000001858

Escitalopram Restores Reversal Learning Impairments in Rats with Lesions of Orbital Frontal Cortex

Autor: Ellen E. Bowman, Connie Sanchez, David S. Tait, Silke Miller, Verity J. Brown, Mary Dovlatyan

Publikováno v: Language, Cognition, and Mind ISBN: 9783030501990

The term ‘cognitive structures’ is used to describe the fact that mental models underlie thinking, reasoning and representing. Cognitive structures generally improve the efficiency of information processing by providing a situational framework wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ff28152ed64c039c3aa4ce521f7f8c5
https://doi.org/10.1007/978-3-030-50200-3_18