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pro vyhledávání: '"Silke Kuhfahl"'
Autor:
Silke Kuhfahl, Elisabeth Schwarz
Publikováno v:
Biological Chemistry. 396:215-223
The large proregions of cystine knot growth factors exert several important biological functions. Previous results have shown that the proregion of BMP2 retards the activity of the mature growth factor. Hitherto, no information exists about the funct
Autor:
Silke Kuhfahl, Marja Hietala, Stefan Mundlos, Katja Stange, Andreas R. Janecke, Hildegunde Piza-Katzer, Karen Hertel, Petra Seemann, Tino Thieme, Katarina Dathe, Elisabeth Schwarz, Maila Penttinen
Publikováno v:
Journal of Molecular Biology
Growth and differentiation factor 5 (GDF5) plays a central role in bone and cartilage development by regulating the proliferation and differentiation of chondrogenic tissue. GDF5 is synthesized as a preproprotein. The biological function of the prore
Autor:
Jay C. Groppe, Andrea Sinz, Elisabeth Schwarz, Anja Hauburger, Mike Schutkowski, Christian Ihling, Sladjana Tomic, Silke Kuhfahl, Tino Thieme
Publikováno v:
Biochemical and biophysical research communications. 408(2)
Proregions of bone morphogenetic proteins (BMPs) fulfill important biological functions as intramolecular chaperones and for extracellular targeting of the mature signal ligand. Knowledge of the structures of the proregions would contribute to a more