Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silke Jamitzky"'
Autor:
Silke Jamitzky, Bianca Altvater, Carolin Krekeler, Laura Hoen, Caroline Brandes, Julia Ebbinghaus, Lisa Richter, Lisa Kosel, Laurin Ochs, Nicole Farwick, Katja Urban, Lena Kluge, Lara Bücker, Dennis Görlich, Ian C. D. Johnston, Rita Pfeifer, Wolfgang Hartmann, Claudia Rossig, Sareetha Kailayangiri
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Carbohydrate markers of immature cells during prenatal human development can be aberrantly expressed in cancers and deserve evaluation as immune targets. A candidate target in Ewing sarcoma is the globo-series ganglioside stage-specific embr
Externí odkaz:
https://doaj.org/article/c7a03da52b4a4a629ef2068b60b10500
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Application of the CAR targeting strategy in solid tumors is challenged by the need for adequate target antigens. As a consequence of their tissue origin, embryonal cancers can aberrantly express membrane-anchored gangliosides. These are carbohydrate
Externí odkaz:
https://doaj.org/article/e57d171721284978aebf6c971082396e
Autor:
Wolfgang Hartmann, Lea Greune, Silke Jamitzky, Bianca Altvater, Jutta Meltzer, Uta Dirksen, Andreas Ranft, Sareetha Kailayangiri, Jendrik Hardes, Susanne Amler, Claudia Rossig, Eva Wardelmann, Maike Fluegge, Christian Spurny, Nicole Farwick
Publikováno v:
Oncotarget
// Christian Spurny 1 , Sareetha Kailayangiri 1 , Bianca Altvater 1 , Silke Jamitzky 1 , Wolfgang Hartmann 2 , Eva Wardelmann 2 , Andreas Ranft 1, 3 , Uta Dirksen 1, 3 , Susanne Amler 4 , Jendrik Hardes 5, 4 , Maike Fluegge 1 , Jutta Meltzer 1 , Nico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17dda1eab73ba14d22d5a41a00bb60c
http://europepmc.org/articles/PMC5814230
http://europepmc.org/articles/PMC5814230
Autor:
Holger N. Lode, Nikolai Siebert, Claudia Rossig, Kornelius Kerl, Ingo Müller, Claudia Göttlich, Stefanie Lesch, Bianca Altvater, Maike Fluegge, Wolfgang Hartmann, Sonja Schelhaas, Silke Jamitzky, Sebastian T. Balbach, Lea Greune, Heike Walles, Johanna Kühnemundt, Jutta Meltzer, Sareetha Kailayangiri, Jan-Henrik Mikesch, Nicole Farwick
Publikováno v:
Mol Ther
Chimeric antigen receptor (CAR) engineering of T cells allows one to specifically target tumor cells via cell surface antigens. A candidate target in Ewing sarcoma is the ganglioside G(D2), but heterogeneic expression limits its value. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c54360ba8e25b4d1bfedff824acf87
https://europepmc.org/articles/PMC6520468/
https://europepmc.org/articles/PMC6520468/
Autor:
Jutta Meltzer, Silke Jamitzky, Bianca Altvater, Katja Urban, Claudia Rossig, Nicole Farwick, Sareetha Kailayangiri, Lea Greune
Publikováno v:
Cancer Research. 80:4999-4999
Preclinical in vivo studies of chimeric antigen receptor (CAR) T cells often rely on NOD-scid gamma (NSG) mouse models which lack T cells, B cells and NK cells and thereby allow for reliable engraftment of human tumor xenografts. But murine myeloid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de53f4dafcac0fd1e039aeed109fa09
https://doi.org/10.1158/1538-7445.am2020-4999
https://doi.org/10.1158/1538-7445.am2020-4999
Publikováno v:
Cancers, Vol 12, Iss 1075, p 1075 (2020)
Cancers
Cancers
Chimeric antigen receptor (CAR) gene-modified T cells (CAR T cells) can eradicate B cell malignancies via recognition of surface-expressed B lineage antigens. Antigen escape remains a major mechanism of relapse and is a key barrier for expanding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b178ea845815d4e9801d5766757950f5
https://doi.org/10.3390/cancers12051075
https://doi.org/10.3390/cancers12051075
Autor:
Claudia Rossig, Silke Jamitzky, Saskia Janneschuetz, Bianca Altvater, Andrea-Caroline Krueger, Sareetha Kailayangiri, Stephanie Piepke, Christian Spurny
Publikováno v:
Pediatric Blood & Cancer. 62:1979-1985
Background Patients with primary metastatic or relapsed Ewing sarcomas (EwS) have a poor prognosis. While inhibitory insulin-like growth factor 1 receptor (IGF-1R)-specific antibodies have shown single agent activity in some patients with refractory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bedbafecfcee820dffb369b61dbb3b
https://doi.org/10.1002/pbc.25619
https://doi.org/10.1002/pbc.25619
Autor:
Sareetha Kailayangiri, Christian Spurny, Jendrik Hardes, Wolfgang Hartmann, Claudia Rossig, Eva Wardelmann, Silke Jamitzky, Uta Dirksen, Bianca Altvater
Publikováno v:
Pediatric bloodcancer. 65(1)
Background Programmed cell death 1 (PD-1) receptor engagement on T cells by its ligand programmed cell death ligand 1 (PD-L1) is a key mechanism of immune escape, and antibody blockade of the interaction has emerged as an effective immunotherapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a453be6616934b889c2b8c105e1225db
https://pubmed.ncbi.nlm.nih.gov/28868758
https://pubmed.ncbi.nlm.nih.gov/28868758
Autor:
Lea Greune, Heinz Wiendl, Silke Jamitzky, Susann Pankratz, Helmut Hanenberg, Maike Fluegge, Bianca Altvater, Constanze Wiek, Sonja Schelhaas, Andreas H. Jacobs, Wolfgang Hartmann, Jutta Meltzer, Claudia Rossig, Sareetha Kailayangiri, Katharina Roellecke, Christian Spurny, Nicole Farwick
Publikováno v:
Oncoimmunology. 6(1)
Activated and in vitro expanded natural killer (NK) cells have substantial cytotoxicity against many tumor cells, but their in vivo efficacy to eliminate solid cancers is limited. Here, we used chimeric antigen receptors (CARs) to enhance the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c96a0dfd377c761a41ec5b6f2cd487
https://pubmed.ncbi.nlm.nih.gov/28197367
https://pubmed.ncbi.nlm.nih.gov/28197367
Autor:
Claudia Rossig, Eva Wardelmann, Jendrik Hardes, Schaefers Michael, Jan-Henrik Mikesch, Wolfgang Hartmann, Petra Fischer, Bianca Altvater, Silke Jamitzky, Stefanie Lesch, Nicole Farwick, Sareetha Kailayangiri, Jutta Meltzer, Sonja Schelhaas
Publikováno v:
Cancer Research. 78:4631-4631
Safe and effective targeting of cancer with chimeric antigen receptor (CAR) engineered T cells relies on the presence of adequate tumor-associated surface antigens. We have found that Ewing sarcomas (EwS) express ganglioside GD2 and are recognized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a710a9d2eb9d8e30b9aa51292cf0c091
https://doi.org/10.1158/1538-7445.am2018-4631
https://doi.org/10.1158/1538-7445.am2018-4631