Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Silke Hoffmann"'
Autor:
Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, Silke Hoffmann, Dieter Willbold
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
GABARAP, like other ATG8 proteins, is a ubiquitin-like modifier and its C-terminal lipid conjugation enables association with cellular membranes. To prevent interference with the lipidation process, N-terminal fluorescent protein (FP) tagging strateg
Externí odkaz:
https://doaj.org/article/a0335537f8ef46718d27cab83238fdd9
Autor:
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities
Externí odkaz:
https://doaj.org/article/03e0e78ce7bf4b4b9c679247f861c77c
Autor:
Julia L. Sanwald, Jochen Dobner, Indra M. Simons, Gereon Poschmann, Kai Stühler, Alina Üffing, Silke Hoffmann, Dieter Willbold
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 85 (2020)
GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, how
Externí odkaz:
https://doaj.org/article/b982a126d53c458c98f91a2da1127f16
Autor:
Julia L. Sanwald, Gereon Poschmann, Kai Stühler, Christian Behrends, Silke Hoffmann, Dieter Willbold
Publikováno v:
Cells, Vol 9, Iss 6, p 1468 (2020)
The autophagy-related ATG8 protein GABARAP has not only been shown to be involved in the cellular self-degradation process called autophagy but also fulfils functions in intracellular trafficking processes such as receptor transport to the plasma mem
Externí odkaz:
https://doaj.org/article/c3929c74fd4e460585d5b86e32d91434
Autor:
Jochen Dobner, Indra M. Simons, Kerstin Rufinatscha, Sebastian Hänsch, Melanie Schwarten, Oliver H. Weiergräber, Iman Abdollahzadeh, Thomas Gensch, Johannes G. Bode, Silke Hoffmann, Dieter Willbold
Publikováno v:
Cells, Vol 9, Iss 5, p 1296 (2020)
The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous struct
Externí odkaz:
https://doaj.org/article/c268994d3f8642ba80da709b21e116bf
Autor:
Yu-Fu Hung, Melanie Schwarten, Silke Hoffmann, Dieter Willbold, Ella H. Sklan, Bernd W. Koenig
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 4119-4130 (2015)
Dengue virus (DENV) is an important human pathogen causing millions of disease cases and thousands of deaths worldwide. Non-structural protein 4A (NS4A) is a vital component of the viral replication complex (RC) and plays a major role in the formatio
Externí odkaz:
https://doaj.org/article/3f4b498c9d7c4082bdcd6142ee3131cd
Autor:
Iman Abdollahzadeh, Johnny Hendriks, Julia L. Sanwald, Indra M. Simons, Silke Hoffmann, Oliver H. Weiergräber, Dieter Willbold, Thomas Gensch
Publikováno v:
Molecules, Vol 24, Iss 9, p 1833 (2019)
Subcellular structures containing autophagy-related proteins of the Atg8 protein family have been investigated with conventional wide-field fluorescence and single molecule localisation microscopy. Fusion proteins of GABARAP and LC3B, respectively, w
Externí odkaz:
https://doaj.org/article/be0b4233eea543d4a67dcf32c946cdb9
Autor:
Yu-Fu Hung, Olga Valdau, Sven Schünke, Omer Stern, Bernd W Koenig, Dieter Willbold, Silke Hoffmann
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86482 (2014)
BACKGROUND: Dengue virus (DENV) is a mosquito-transmitted positive single strand RNA virus belonging to the Flaviviridae family. DENV causes dengue fever, currently the world's fastest-spreading tropical disease. Severe forms of the disease like deng
Externí odkaz:
https://doaj.org/article/d61d2115e2564a85ab5d3703c1a77541
Autor:
Ellen C Kammula, Jessica Mötter, Alexandra Gorgels, Esther Jonas, Silke Hoffmann, Dieter Willbold
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51578 (2012)
HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational
Externí odkaz:
https://doaj.org/article/3a939c0a2c4445dbb4db3fae01f0977f
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10081 (2010)
BACKGROUND: N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT). Prokaryotes are lacking endogenous NMT activity. Recombinant production of N-myristoylated pr
Externí odkaz:
https://doaj.org/article/2de0ee9149df44c0af55f0b71cb12033