Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Silke Heising"'
Autor:
Kieran Patrick, Xiang Tian, David Cartwright, Silke Heising, Matthew S Glover, Ellie N Northall, Lisa Cazares, Sonja Hess, David Baker, Christopher Church, Graeme Davies, Gareth Lavery, Amy J Naylor
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284012 (2023)
Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of C
Externí odkaz:
https://doaj.org/article/cae256c32e144dc28049e61616c1efbe
Autor:
Craig L. Doig, Agnieszka E. Zielinska, Rachel S. Fletcher, Lucy A. Oakey, Yasir S. Elhassan, Antje Garten, David Cartwright, Silke Heising, Ahmed Alsheri, David G. Watson, Cornelia Prehn, Jerzy Adamski, Daniel A. Tennant, Gareth G. Lavery
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inacti
Externí odkaz:
https://doaj.org/article/8d9a163de0734bd78b8d622a8457c287
Autor:
Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107761- (2020)
Summary: Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels,
Externí odkaz:
https://doaj.org/article/4961e1cbcd0b42b7a385bb7cadbfb0b4
Autor:
Laleh Pezhman, Sophie J Hopkin, Jenefa Begum, Silke Heising, Daniela Nasteska, Mussarat Wahid, G Ed Rainger, David J Hodson, Asif J Iqbal, Myriam Chimen, Helen M McGettrick
Publikováno v:
Clinical and Experimental Immunology. 212:1-10
Dysregulation of leukocyte trafficking, lipid metabolism, and other metabolic processes are the hallmarks that underpin and drive pathology in obesity. Current clinical management targets alternations in lifestyle choices (e.g. exercise, weight loss)
Autor:
Alexandra Mazharian, Blandine Maître, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Publikováno v:
Blood Advances. 7:46-59
Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expan
Autor:
Katrina Viloria, Daniela Nasteska, Julia Ast, Annie Hasib, Federica Cuozzo, Silke Heising, Linford J.B. Briant, Martin Hewison, David J. Hodson
GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in transport of circulating vitamin 25(OH)D and fatty acids, as well as actin-scavenging. In the pancreatic islets, the gene encoding GC, GC, is highly-localized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afef49093356a6177f98dec0db2c8f8
https://doi.org/10.2337/figshare.21553317.v1
https://doi.org/10.2337/figshare.21553317.v1
Autor:
Samuel Heaselgrave, Silke Heising, Stuart Morgan, Ali Kabli, Michael Sagmeister, Rowan Hardy, Craig Doig, Nicholas Morton, Kostas Tsintzas, Gareth Lavery
Publikováno v:
Endocrine Abstracts.
Autor:
Silke Heising, Samuel Heaselgrave, Stuart Morgan, Ali Kabli, Craig Doig, Kostas Tsintzas, Gareth Lavery
Publikováno v:
Endocrine Abstracts.
Autor:
Ali Kabli, Silke Heising, Samuel Heaselgrave, Yasir Elhassan, Rowan Hardy, Oyvind Stromland, Mathias Ziegler, Stuart Morgan, David Hodson, Gareth Lavery
Publikováno v:
Endocrine Abstracts.
Autor:
Kostas Tsintzas, Samuel Heaselgrave, Silke Heising, Stuart Morgan, Ali Kabli, Craig Doig, Nicholas Morton, Gareth Lavery
Publikováno v:
Journal of the Endocrine Society. 6:A141-A142
Introduction Glucocorticoids are vital for regulating metabolic processes, as well as use in medical treatments. However glucocorticoid excess is known to cause negative metabolic effects including hyperglycaemia, muscle atrophy and fat accumulation,