Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Silke Hedtfeld"'
Autor:
Alexander Schnell, Stephanie Tamm, Silke Hedtfeld, Claudio Rodriguez Gonzalez, Andre Hoerning, Nico Lachmann, Frauke Stanke, Anna-Maria Dittrich, Antje Munder
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6367 (2024)
The Cystic Fibrosis Conductance Transmembrane Regulator gene encodes for the CFTR ion channel, which is responsible for the transport of chloride and bicarbonate across the plasma membrane. Mutations in the gene result in impaired ion transport, subs
Externí odkaz:
https://doaj.org/article/e71268afea98487facba01883d27a09f
Autor:
Frauke Stanke, Sophia T. Pallenberg, Stephanie Tamm, Silke Hedtfeld, Ella M. Eichhorn, Rebecca Minso, Gesine Hansen, Tobias Welte, Annette Sauer-Heilborn, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Anna-Maria Dittrich
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Defects in expression, maturation or function of the epithelial membrane glycoprotein CFTR are causative for the progressive disease cystic fibrosis. Recently, molecular therapeutics that improve CFTR maturation and functional defects hav
Externí odkaz:
https://doaj.org/article/7cc5bf37360f4ab5bcfbf6cd9a5992a0
Autor:
Tim Becker, Andreas Pich, Stephanie Tamm, Silke Hedtfeld, Mohammed Ibrahim, Janine Altmüller, Nina Dalibor, Mohammad Reza Toliat, Sabina Janciauskiene, Burkhard Tümmler, Frauke Stanke
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract SCNN1B encodes the beta subunit of the epithelial sodium channel ENaC. Previously, we reported an association between SNP markers of SCNN1B gene and disease severity in cystic fibrosis-affected sibling pairs. We hypothesized that factors int
Externí odkaz:
https://doaj.org/article/dcc752896878496ebfa52dadd5b3f362
Autor:
Frauke Stanke, Tim Becker, Haide Susanne Ismer, Inga Dunsche, Silke Hedtfeld, Julia Kontsendorn, Anna-Maria Dittrich, Burkhard Tümmler
Publikováno v:
Genes, Vol 12, Iss 10, p 1554 (2021)
CFTR encodes for a chloride and bicarbonate channel expressed at the apical membrane of polarized epithelial cells. Transepithelial sodium transport mediated by the amiloride-sensitive sodium channel ENaC is thought to contribute to the manifestation
Externí odkaz:
https://doaj.org/article/b98c1a6fb89348b9ad6adbcda1828c47
Autor:
Patricia Moran Losada, Philippe Chouvarine, Marie Dorda, Silke Hedtfeld, Samira Mielke, Angela Schulz, Lutz Wiehlmann, Burkhard Tümmler
Publikováno v:
ERJ Open Research, Vol 2, Iss 2 (2016)
Chronic airway infections determine most morbidity in people with cystic fibrosis (CF). Herein, we present unbiased quantitative data about the frequency and abundance of DNA viruses, archaea, bacteria, moulds and fungi in CF lower airways. Induced s
Externí odkaz:
https://doaj.org/article/b330c58af417427ea03a99dbb7425a20
Analysis of CF patient survival confirms STAT3 as a CF-modifying gene with changing impact over time
Autor:
Inga Dunsche, Ellen L Raddatz, Haide Ismer, Silke Hedtfeld, Stephanie Tamm, Saskia Moser, Julia Kontsendorn, Burkhard Tümmler, Sabina Janciauskiene, Anna-Maria Dittrich, Frauke Stanke
Publikováno v:
Human Molecular Genetics. 32:543-550
Introduction and aim The signal transducer and activator of transcription 3 (STAT3) has been identified as one of the cystic fibrosis (CF) modifying genes. In this study, we aimed to assess the association between STAT3 genotype and CF patient surviv
Autor:
Katarzyna Pienkowska, Marie-Madlen Pust, Margaux Gessner, Svenja Gaedcke, Ajith Thavarasa, Ilona Rosenboom, Patricia Morán Losada, Rebecca Minso, Christin Arnold, Silke Hedtfeld, Marie Dorda, Lutz Wiehlmann, Jochen G. Mainz, Jens Klockgether, Burkhard Tümmler
Publikováno v:
Microbiology Spectrum. 11
Cystic fibrosis (CF) is the most common life-limiting monogenetic disease in European populations and is caused by mutations in the CFTR gene. Chronic airway infections with opportunistic pathogens are the major morbidity that determines prognosis an
Autor:
Mohammed Ibrahim, Janine Altmüller, Mohammad R. Toliat, Burkhard Tümmler, Sabina Janciauskiene, Tim Becker, Frauke Stanke, Nina Dalibor, Silke Hedtfeld, Stephanie Tamm, Andreas Pich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
SCNN1B encodes the beta subunit of the epithelial sodium channel ENaC. Previously, we reported an association between SNP markers of SCNN1B gene and disease severity in cystic fibrosis-affected sibling pairs. We hypothesized that factors interacting
Autor:
Inga, Dunsche, Ellen L, Raddatz, Haide, Ismer, Silke, Hedtfeld, Steffi, Tamm, Saskia, Moser, Julia, Kontsendorn, Burkhard, Tümmler, Sabina, Janciauskiene, Anna-Maria, Dittrich, Frauke, Stanke
Publikováno v:
Human molecular genetics.
The signal transducer and activator of transcription 3 (STAT3) has been identified as one of the cystic fibrosis (CF) modifying genes. In this study, we aimed to assess the association between STAT3 genotype and CF patient survival over several decad
Autor:
Anna-Maria Dittrich, Silke Hedtfeld, Haide Susanne Ismer, Burkhard Tümmler, Inga Dunsche, Frauke Stanke, Tim Becker, Julia Kontsendorn
Publikováno v:
Genes
Volume 12
Issue 10
Genes, Vol 12, Iss 1554, p 1554 (2021)
Volume 12
Issue 10
Genes, Vol 12, Iss 1554, p 1554 (2021)
CFTR encodes for a chloride and bicarbonate channel expressed at the apical membrane of polarized epithelial cells. Transepithelial sodium transport mediated by the amiloride-sensitive sodium channel ENaC is thought to contribute to the manifestation