Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Silke Finster"'
Autor:
Kerstin Crusius, Silke Finster, John McClary, Jian-Ai Xuan, Hong-Tao Lu, Alicia Newton, Brent Larsen, Peter Bringmann, Debbie Allen, Wei Xia, Ronald R. Cobb, Sara Biancalana, Douglas W. Schneider
Publikováno v:
Gene. 380:111-119
The detection and purification of proteins are often time-consuming and frequently involve complicated protocols. The addition of a peptide tag to recombinant proteins can make this process more efficient. Many of the commonly used tags, such as Flag
Autor:
Dao Lentz, Marc Whitlow, Zheng Chang, Harald Dinter, Mike Ferrer, Silke Finster, Marc Adler, Daguang Zhu, Sandra L. Biroc, Richard I. Feldman, Bruno Alicke, Monica Kochanny, Judi Bryant, Brad O. Buckman, Mark A. Polokoff, Arnaiz Damian O, James M. Wu, Shendong Yuan
Publikováno v:
Journal of Biological Chemistry. 280:19867-19874
The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis and represents a promising target for anticancer drugs. Here, we describe three
Autor:
Felipe Monteclaro, Mithra Mahmoudi, Brent Larsen, Tara Heitner, Bing Liu, Beate Müller-Tiemann, David Vogel, Xiao-Yan Zhao, Ying Zhu, Silke Finster, Hongxing Zhou, David R. Light, Kirk Mclean, Noboru Satozawa, Ronald R. Cobb
Publikováno v:
Journal of biomolecular screening. 11(8)
A therapeutic antibody candidate (AT-19) isolated using multivalent phage display binds native tomoregulin (TR) as a mul-timer not as a monomer. This report raises the importance of screening and selecting phage antibodies on native antigen and reemp
Autor:
Doug Schneider, Silke Finster, Alicia Newton, Rick Lin, David Vogel, Pam Toy, Bob Mintzer, Marc Whitlow, Gordon Parry, Jian Ai Xuan, Qingyu Wu, Ying Zhu, Mark Polokoff, Harald Dinter, Renate Parry, David R. Light
Publikováno v:
Cancer research. 66(7)
Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA is significantly elevated in most prostate tumors, as well as a sign
Autor:
Shendong Yuan, Silke Finster, Marc Whitlow, Marc Adler, Karen May, Brent R. Larsen, Brad O. Buckman, Lorraine Kent, Raju Mohan, Imadul Islam, Judi Bryant
Publikováno v:
Biochemistry. 44(26)
This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recen
Autor:
Silke Finster, Warren Manzana, Brent R. Larsen, Peter Bringmann, David R. Light, Sabine Schirm, Ronald R. Cobb, Eric Blasko, Jennifer Pearson, Katalin Kauser, John McClary, Sara Biancalana
Publikováno v:
Protein expression and purification. 42(2)
Prolyl-4-hydroxylase domain-containing enzymes (PHDs) mediate the oxygen-dependent regulation of the heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1). Under normoxic conditions, one of the subunits of HIF-1, HIF-1alpha, is hydrox