Author response for 'Effects of sequential treatment with lixisenatide, insulin glargine , or their combination on meal‐related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes'

Autor: null Juris J. Meier, null Björn A. Menge, null Nina Schenker, null Silke Erdmann, null Melanie Kahle‐Stephan, null Freimut Schliess, null Christoph Kapitza, null Michael A. Nauck

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::863aa3d1bcbfdb65a069c58f8dc79cae
https://doi.org/10.1111/dom.13935/v2/response1

Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions

Autor: Sven Hennig, Alexander Wolf, Stefanie Bovens, Herbert Waldmann, Christian Ottmann, Rolf Rose, Micheline Rose, Silke Erdmann

Publikováno v: Rose, R, Erdmann, S, Bovens, S, Wolf, A, Rose, M, Hennig, S, Waldmann, H & Ottmann, C 2010, ' Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions ', Angewandte Chemie International Edition in English, vol. 49, no. 24, pp. 4129-32 . https://doi.org/10.1002/anie.200907203
Angewandte Chemie International Edition in English, 49(24), 4129-32. John Wiley and Sons Ltd
Angewandte Chemie-International Edition, 49(24), 4129-4132. Wiley

Two structurally unrelated small molecules that stabilize the interaction of a 14–3–3 protein with the proton pump PMA2 have been identified. The compounds are selective among different 14–3–3 protein–protein interactions and are active in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31ecb1ee3a1f07a79d6bd6b61dd9a75
https://doi.org/10.1002/anie.200907203

Conditional expression of hepatocyte nuclear factor-1β, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic β-cells

Autor: Heike Thomas, Lorna W. Harries, Noel G. Morgan, Silke Erdmann, Ludger Klein-Hitpass, Sabine Senkel, Gerhart U. Ryffel, Ewan R. Pearson, Andrew T. Hattersley, Coralie Bingham, Hannah J. Welters

Publikováno v: Journal of Endocrinology. 190:171-181

Mutations in the gene encoding hepatocyte nuclear factor (HNF)1beta result in maturity-onset diabetes of the young-(MODY)5, by impairing insulin secretory responses and, possibly, by reducing beta-cell mass. The functional role of HNF1beta in normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff5920528914487be38dce735591be9
https://doi.org/10.1677/joe.1.06768

Seven genes that are differentially transcribed in colorectal tumor cell lines

Autor: Sebastian Hentsch, Ulrich Finke, Oliver Müller, Ingrid Hoffmann, Mary Pat Moyer, Ute Melchers, Silke Erdmann, Inko Nimmrich

Publikováno v: Cancer Letters. 160:37-43

To identify genes which are differentially transcribed in colorectal tumor cells, we compared the two human tumor cell lines, SW480 and HCT116, with the cell line, NCM460, from normal colon epithelium as a control. Using the methods of differential d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73fb4e7b32ca0c8326ce4779296de4e
https://doi.org/10.1016/s0304-3835(00)00553-x

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma

Autor: Belén Lucas, Gerhart U. Ryffel, Jörn Lausen, Karen Grigo, Ludger Klein-Hitpass, Silke Erdmann

Publikováno v: Oncogene. 24(42)

Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor known to regulate a large number of genes in hepatocytes and pancreatic beta cells. Although HNF4alpha is highly expressed in some sections of the kidney, little i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2002530f65c514ed169a70d7e51d2fb
https://pubmed.ncbi.nlm.nih.gov/16007190