Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Silke Bergemann"'
Autor:
Markus Tiemann, Eric Nawrotzky, Peter Schmieder, Leon Wehrhan, Silke Bergemann, Vera Martos, Wei Song, Christoph Arkona, Bettina G. Keller, Jörg Rademann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(57)
Discovery of protein-binding fragments for precisely defined binding sites is an unmet challenge to date. Herein, formylglycine is investigated as a molecular probe for the sensitive detection of fragments binding to a spatially defined protein site
Autor:
Enaam Masri, Peter Demirel, Stephanie Kallis, Christina Fischer, Silke Bergemann, Christoph Nitsche, Ralf Bartenschlager, Jörg Rademann, Thomas Rudolf, Christoph Arkona, Barbara Schroeder, Lisa Redl
Publikováno v:
ACS Med Chem Lett
[Image: see text] Viral proteases have been established as drug targets in several viral diseases including human immunodeficiency virus and hepatitis C virus infections due to the essential role of these enzymes in virus replication. In contrast, no
Autor:
Tim M. Sarter, Rafe Yousef, David Schaller, Szymon Pach, Jörg Rademann, Silke Bergemann, Gerhard Wolber, Christoph Arkona, Christoph Nitsche
Publikováno v:
ACS Med Chem Lett
[Image: see text] The pivotal role of viral proteases in virus replication has already been successfully exploited in several antiviral drug design campaigns. However, no efficient antivirals are currently available against flaviviral infections. In
Autor:
Gerhard Rubner, Kerstin Bensdorf, Brigitte Kircher, Ronald Gust, Anja Wellner, Silke Bergemann, Ingo Ott
Publikováno v:
Journal of Medicinal Chemistry. 53:6889-6898
[(μ(4)-η(2))-(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), a derivative of aspirin (ASS), demonstrated high growth-inhibitory potential against various tumor cells with interference in the arachidonic acid cascade as probable mode
Autor:
Ronald Gust, Silke Bergemann, Victor M. Deflon, Hung Huy Nguyen, Pedro I. S. Maia, Jesudas J. Jegathesh, Ulrich Abram
Publikováno v:
Inorganic Chemistry. 48:9356-9364
Reactions of N-[N',N'-diethylamino(thiocarbonyl)]benzimidoyl chloride with 4,4-dialkylthiosemicarbazides give a novel class of thiosemicarbazides/thiosemicarbazones, H(2)L, which causes a remarkable reduction of cell growth in in vitro experiments. T
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3497-3511
Two new attractive series of allocolchicinoids were designed as inhibitors of tubulin assembly using the potent ketone 4 and the tetracyclic, pyrazole annulated NCME variant 7 (NCME = N-acetyl colchinol-O-methylether (2)) as lead structures. The firs
Publikováno v:
Archiv der Pharmazie. 336:242-250
Some 5-acylaminoacylamino-benzophenone derivatives were designed as bisubstrate analogue farnesyltransferase inhibitors. These compounds turned out to be only weakly active against farnesyltransferase, but displayed an antiproliferative effect render
Autor:
Adelheid Hagenbach, Victor M. Deflon, Pedro I. S. Maia, Hung Huy Nguyen, Silke Bergemann, Ronald Gust, Ulrich Abram
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H2L1) derived from N-[N′,N′-dialkylamino(thiocarbonyl)]benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have been synthesized by ligand-exchange reactions s
Autor:
Adelheid Hagenbach, Daniela Ponader, Pedro I. S. Maia, Hung Huy Nguyen, Silke Bergemann, Ulrich Abram, Ronald Gust, Victor M. Deflon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Na[AuCl(4)]·2H(2)O reacts with tridentate thiosemicarbazide ligands, H(2)L1, derived from N-[N',N'-dialkylamino(thiocarbonyl)]benzimidoyl chloride and thiosemicarbazides under formation of air-stable, green [AuCl(L1)] complexes. The organic ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cb295eb06a402162cf1635cc0b2955
Publikováno v:
European journal of medicinal chemistry. 45(11)
[(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), a derivative of the nonsteroidal anti-inflammatory drug aspirin(®) (ASS), demonstrated high cytotoxic potential against various tumor cells. The [acetylene]Co(2)(CO)(6) cluster strongly