Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

Autor: Adam M. Thorne, Justina C. Wolters, Bianca Lascaris, Silke B. Bodewes, Veerle A. Lantinga, Otto B. van Leeuwen, Iris E. M. de Jong, Kirill Ustyantsev, Eugene Berezikov, Ton Lisman, Folkert Kuipers, Robert J. Porte, Vincent E. de Meijer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Normothermic machine perfusion (NMP) after static cold storage is increasingly used for preservation and assessment of human donor livers prior to transplantation. Biliary viability assessment during NMP reduces the risk of post-transplant b

Externí odkaz: https://doaj.org/article/4196b91cef814f6483a06b7a72696332

Extended hypothermic oxygenated machine perfusion enables ex situ preservation of porcine livers for up to 24 hours

Autor: Isabel M.A. Brüggenwirth, Otto B. van Leeuwen, Yvonne de Vries, Silke B. Bodewes, Jelle Adelmeijer, Janneke Wiersema-Buist, Ton Lisman, Paulo N. Martins, Vincent E. de Meijer, Robert J. Porte

Publikováno v: JHEP Reports, Vol 2, Iss 2, Pp - (2020)

Background & Aims: End-ischemic hypothermic oxygenated machine perfusion (HOPE) of the donor liver for 1–2 h mitigates ischemia-reperfusion injury during subsequent liver transplantation. Extended preservation time may be preferred to facilitate di

Externí odkaz: https://doaj.org/article/b1fc3b7b1ac9425db4cb8f2bca75c9f8

Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers

Autor: Otto B. van Leeuwen, Silke B. Bodewes, Veerle A. Lantinga, Martijn P.D. Haring, Adam M. Thorne, Isabel M.A. Brüggenwirth, Aad P. van den Berg, Marieke T. de Boer, Iris E.M. de Jong, Ruben H.J. de Kleine, Bianca Lascaris, Maarten W.N. Nijsten, Koen M.E.M. Reyntjens, Vincent E. de Meijer, Robert J. Porte

Publikováno v: American Journal of Transplantation, 22(6), 1658-1670. Wiley

Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment of high-risk donor livers, whereas dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia-reperfusion injury. We aimed to resuscitate and test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f476d243183ba014e9217c26c0fe572
https://doi.org/10.1111/ajt.17022

Ex Situ Dual Hypothermic Oxygenated Machine Perfusion for Human Split Liver Transplantation

Autor: Maarten W Nijkamp, Robert J. Porte, Vincent E de Meijer, Hermien Hartog, Wojciech G. Polak, Ruben H J de Kleine, Silke B Bodewes, Veerle A Lantinga, Joost Sprakel, Adam M Thorne

Publikováno v: Transplantation Direct
Transplantation Direct, Vol 7, Iss 3, p e666 (2021)
Transplantation direct, 7(3):e666. LIPPINCOTT WILLIAMS & WILKINS
Transplantation Direct, 7(3):e666. Wolters Kluwer Health

Supplemental Digital Content is available in the text.
Background. Liver splitting allows the opportunity to share a deceased graft between 2 recipients but remains underutilized. We hypothesized that liver splitting during continuous dual hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fa540109693723ce082e7aff1ed8c6
http://europepmc.org/articles/PMC7862033

A Clinical Comparison of Two Different Oxygen Carriers for Combined Hypothermic and Normothermic Machine Perfusion of High-risk Donor Livers

Autor: V. E. de Meijer, Robert J. Porte, Veerle A Lantinga, A. P. van den Berg, Isabel M A Brüggenwirth, M. de Boer, R. H. J. de Kleine, Y. de Vries, Silke B Bodewes, Adam M Thorne, O. B. van Leeuwen, Ton Lisman, Martijn P D Haring

Publikováno v: HPB. 23:S689

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96488f0a73346cc2e293a517886a7876
https://doi.org/10.1016/j.hpb.2021.08.038