Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Silke Alt"'
Autor:
Jennifer L. Edwards, Jacqueline T. Balthazar, Danillo L. A. Esposito, Julio C. Ayala, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Silke Alt, Thomas Hesterkamp, Miriam Grosse, Marc Stadler, Daniel Golparian, Magnus Unemo, Timothy D. Read, William M. Shafer
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Gonorrhea remains a major global public health problem because of the high incidence of infection (estimated 82 million cases in 2020) and the emergence and spread of Neisseria gonorrhoeae strains resistant to previous and current antibiotic
Externí odkaz:
https://doaj.org/article/961e129f07f64b2fb61e13b4c0e7ef00
Autor:
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluatio
Externí odkaz:
https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b
Autor:
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Externí odkaz:
https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Autor:
Arianna Tocchetti, Roberta Bordoni, Giuseppe Gallo, Luca Petiti, Giorgio Corti, Silke Alt, Joao C S Cruz, Anna Maria Salzano, Andrea Scaloni, Anna Maria Puglia, Gianluca De Bellis, Clelia Peano, Stefano Donadio, Margherita Sosio
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133705 (2015)
We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria and producing the thiopeptide GE2270. The P. rosea genome presents considerable convergenc
Externí odkaz:
https://doaj.org/article/c70781536b33424ca81d8a7674fd745c
Publikováno v:
Marine Drugs, Vol 14, Iss 4, p 78 (2016)
Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of
Externí odkaz:
https://doaj.org/article/a89884615ac248f594977a76cfb2afea
Autor:
Alexandra Ehrens, Andrea Schiefer, Anna K. Krome, Tim Becker, Katharina Rox, Helene Neufeld, Tilman Aden, Karl G. Wagner, Rolf Müller, Miriam Grosse, Marc Stadler, Gabriele M. König, Stefan Kehraus, Silke Alt, Thomas Hesterkamp, Marc Peter Hübner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Frontiers in Tropical Diseases. 3
Corallopyronin A (CorA), a natural product antibiotic of Corallococcus coralloides, inhibits the bacterial DNA-dependent RNA polymerase. It is active against the essential Wolbachia endobacteria of filarial nematodes, preventing development, causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e66de99122731014d88f75de028823d4
https://doi.org/10.3389/fitd.2022.983107
https://doi.org/10.3389/fitd.2022.983107
Autor:
Jennifer L. Edwards, Jacqueline T. Balthazar, Danillo L. A. Esposito, Julio C. Ayala, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Silke Alt, Thomas Hesterkamp, Miriam Grosse, Marc Stadler, Daniel Golparian, Magnus Unemo, Timothy D. Read, William M. Shafer
Publikováno v:
mSphere. 7(5)
Gonorrhea remains a major global public health problem because of the high incidence of infection (estimated 82 million cases in 2020) and the emergence and spread of Neisseria gonorrhoeae strains resistant to previous and current antibiotics used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d1cf2bae2c02220579d6d511572b88
https://pubmed.ncbi.nlm.nih.gov/36094073
https://pubmed.ncbi.nlm.nih.gov/36094073
Autor:
Silke Alt, Douglas Haggstrom, Helmut Kessmann, Florian Kloss, Christian Elias Schneider, Timo Jäger, Torsten Schwede, Axel Brakhage, Christoph Dehio
Publikováno v:
Nature reviews. Drug discovery. 21(9)
No abstract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e15e4763cce756348ac376a77e84b34
https://pubmed.ncbi.nlm.nih.gov/35974146
https://pubmed.ncbi.nlm.nih.gov/35974146
Autor:
Ian H. Gilbert, Kenneth Pfarr, Timo Jaeger, Mika Lindvall, Anders Karlén, Philippe Glaser, Jennifer Herrmann, Marco Pieroni, Bertrand Aigle, Evi Stegmann, Heather Graz, Andrea Schiefer, Jean-Luc Pernodet, Thomas Hesterkamp, Rui Moreira, Heike Brötz-Oesterhelt, Andrew W. Truman, Andreas Keller, Ludovic Halby, Alexander Titz, José R. Tormo, Michael Graz, Kira J. Weissman, Olga Genilloud, Marc Stadler, Claus-Michael Lehr, Paola B. Arimondo, Mark Brönstrup, Savithri Ramurthy, Eriko Takano, Frédéric Peyrane, Mathias Winterhalter, Marnix H. Medema, Maarten van Dongen, Anna K. H. Hirsch, Achim Hoerauf, Helge B. Bode, Laurent Fraisse, Laura J. V. Piddock, Martin Empting, Brigitta Loretz, Yanyan Li, Heinz E. Moser, Tilmann Weber, Marcus Miethke, Silke Alt, Stefano Sabatini, Wolfgang Wohlleben, Peter Hammann, Stefano Donadio, Andriy Luzhetskyy, Myriam Seemann, Rolf Müller, Hrvoje Petković
Publikováno v:
Nature Reviews. Chemistry
Nature Reviews Chemistry
Nature Reviews Chemistry, Nature Publishing Group, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Nature Reviews Chemistry, 5, 726-749
Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Nature Reviews Chemistry 5 (2021)
Nature Reviews Chemistry
Nature Reviews Chemistry, Nature Publishing Group, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Nature Reviews Chemistry, 5, 726-749
Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Nature Reviews Chemistry 5 (2021)
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6afeefa93064508d90818e2ce9e55e
https://pubmed.ncbi.nlm.nih.gov/34426795
https://pubmed.ncbi.nlm.nih.gov/34426795
Autor:
Sibyl F. D. Batey, Barrie Wilkinson, Silke Alt, Govind Chandra, Thomas A. Scott, Patrick Wiencek, Christopher S. Francklyn
Publikováno v:
ACS Chemical Biology. 14:2663-2671
To meet the ever-growing demands of antibiotic discovery, new chemical matter and antibiotic targets are urgently needed. Many potent natural product antibiotics which were previously discarded can also provide lead molecules and drug targets. One su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df58ea1e233b035f84800be7a0ce57ea
https://doi.org/10.1021/acschembio.9b00590
https://doi.org/10.1021/acschembio.9b00590