Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Silja Mordhorst"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1652-1670 (2024)
This review article aims to highlight the role of methyltransferases within the context of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. Methyltransferases play a pivotal role in the biosynthesis of divers
Externí odkaz:
https://doaj.org/article/3a16fd771d7943b3893ad6752fbb83c1
Autor:
Lukas Gericke, Dipali Mhaindarkar, Lukas C. Karst, Sören Jahn, Marco Kuge, Michael K. F. Mohr, Jana Gagsteiger, Nicolas V. Cornelissen, Xiaojin Wen, Silja Mordhorst, Henning J. Jessen, Andrea Rentmeister, Florian P. Seebeck, Gunhild Layer, Christoph Loenarz, Jennifer N. Andexer
Publikováno v:
ChemBioChem. 24
Autor:
Silja Mordhorst, Thomas Badmann, Nina M. Bösch, Brandon I. Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna L. Vagstad
Publikováno v:
ACS Chemical Biology, 18 (3)
Landornamide A is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product with antiviral activity. Its biosynthetic gene cluster encodes─among other maturases─the peptide arginase OspR, which converts arginine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8885b65d91646c5228f913ab872aacff
Publikováno v:
RSC Chemical Biology, 4 (1)
RSC Chemical Biology, 4, 7-36
RSC Chemical Biology, 4, 7-36
Peptide natural products are important lead structures for human drugs and many nonribosomal peptides possess antibiotic activity. This makes them interesting targets for engineering approaches to generate peptide analogues with, for example, increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2abf53c86232f462beb0d0055095cc
https://hdl.handle.net/20.500.11850/592436
https://hdl.handle.net/20.500.11850/592436
Autor:
Lukas Gericke, Dipali Mhaindarkar, Lukas Karst, Sören Jahn, Marco Kuge, Michael K. F. Mohr, Jana Gagsteiger, Nicolas V. Cornelissen, Xiaojin Wen, Silja Mordhorst, Henning J. Jessen, Andrea Rentmeister, Florian P. Seebeck, Gunhild Layer, Christoph Loenarz, Jennifer N. Andexer
S-Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl transfer, and radical reactions. This versatility renders SAM-dependent enzymes of great interest in biocatalysis. The usage of SAM analogues adds to this diversity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08fe24e923b40be13a74349ce540daf4
https://doi.org/10.1101/2022.09.26.509380
https://doi.org/10.1101/2022.09.26.509380
Autor:
Désirée Popadić, Jennifer N. Andexer, Mike H N Dang Thai, Dipali Mhaindarkar, Silja Mordhorst, Helen C. Hailes
Publikováno v:
RSC Chemical Biology, 2 (3)
Rsc Chemical Biology
Rsc Chemical Biology
The ubiquitous cofactor S-adenosyl-l-methionine (SAM) is part of numerous biochemical reactions in metabolism, epigenetics, and cancer development. As methylation usually improves physiochemical properties of compounds relevant for pharmaceutical use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e60c56dd36248018d2ab8567bf633ce
https://hdl.handle.net/20.500.11850/490473
https://hdl.handle.net/20.500.11850/490473
Publikováno v:
Angewandte Chemie (International ed. in English). 59(48)
Ornithine is a component of many bioactive nonribosomal peptides but is challenging to incorporate into ribosomal products. We recently identified OspR, a cyanobacterial arginase-like enzyme that installs ornithines in the antiviral ribosomally synth
Autor:
Silja Mordhorst, Jennifer N. Andexer
Publikováno v:
Natural product reports. 37(10)
Covering: up to the beginning of 2020Enzymes depending on cofactors are essential in many biosynthetic pathways of natural products. They are often involved in key steps: catalytic conversions that are difficult to achieve purely with synthetic organ
Autor:
Petra C. F. Oyston, Stefan Gerhardt, Henning J. Jessen, Jennifer N. Andexer, Alexandre Hofer, Alice E. Parnell, Oliver Einsle, Daniel Wohlwend, Nikola J. Schwarzer, Peter L. Roach, Mariacarmela Giurrandino, Josh P. Prince, Silja Mordhorst, Florian Kemper
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3350-3355
Inorganic polyphosphate is a ubiquitous, linear biopolymer built of up to thousands of phosphate residues that are linked by energyrich phosphoanhydride bonds. Polyphosphate kinases of the family 2 (PPK2) use polyphosphate to catalyze the reversible
Autor:
Silja Mordhorst, Alice Maurer, Johanna Brech, Jun. Prof. Dr. Jennifer N. Andexer, Désirée Popadić
Publikováno v:
ChemCatChem. 9:4164-4168
Coenzyme A (CoA) is a common cofactor in biochemical reactions, and CoA-dependent enzymes catalyze essential steps in anabolism and catabolism. This complex molecule also plays an important role in the synthesis of many high-value products, such as s