Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Silin Sa"'
Autor:
Armando Reyes-Palomares, Mingxia Gu, Fabian Grubert, Ivan Berest, Silin Sa, Maya Kasowski, Christian Arnold, Mao Shuai, Rohith Srivas, Simon Miao, Dan Li, Michael P. Snyder, Marlene Rabinovitch, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes
Externí odkaz:
https://doaj.org/article/af8f51e6fdcf4006aee980f4873bd8eb
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/cff91f7335bb4975b30f6b420d9d911e
Autor:
Caiyun G. Li, Cathal Mahon, Nathaly M. Sweeney, Erik Verschueren, Vivek Kantamani, Dan Li, Jan K. Hennigs, David P. Marciano, Isabel Diebold, Ossama Abu-Halawa, Matthew Elliott, Silin Sa, Feng Guo, Lingli Wang, Aiqin Cao, Christophe Guignabert, Julie Sollier, Nils P. Nickel, Mark Kaschwich, Karlene A. Cimprich, Marlene Rabinovitch
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1333-1343.e7 (2019)
Summary: Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA damage sensor MRE11-RAD50-NBS1 (MRN) and the E3 ubiquitin ligase UB
Externí odkaz:
https://doaj.org/article/4b2b333c73b8412195c17cfba09e970c
Autor:
Akshay Sanghi, Stephen Dalton, Maya Kasowski, Michael Kulik, Fabian Grubert, Damek V. Spacek, Mariana Ruiz-Velasco, Qing Liu, Anshul Kundaje, Marlene Rabinovitch, Benjamin Geller, Anil Narasimha, Peyton Greenside, Judith B. Zaugg, Nasa Sinnott-Armstrong, Michael Snyder, Silin Sa, Rohith Srivas
Publikováno v:
Nature
Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to
Autor:
Toshie Saito, Lingli Wang, Marlene Rabinovitch, Kazuya Miyagawa, Jan K. Hennigs, Caiyun G. Li, Silin Sa, Minyi Shi, Pin-I Chen, Zhixin Zhao, Aiqin Cao, Shalina Taylor, Michael Snyder, Mouer Wang
Publikováno v:
Circulation Research. 124:211-224
Rationale: Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on their metabolic state and gene expression profile, features influenced by contact with neighboring cells such as pericytes and smooth muscle cells (SMC). Failu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Advancements in fields of multi-omics analysis and cell-based therapies depend upon efficient cell processing tools to isolate rare cancer and immune cells from complex biologic samples as an initial step in sample preparation. Conventiona
Autor:
Ivan Berest, Silin Sa, Christian Arnold, Michael Snyder, Armando Reyes-Palomares, Maya Kasowski, Marlene Rabinovitch, Fabian Grubert, Mao Shuai, Rohith Srivas, Mingxia Gu, Simon Miao, Dan Li, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Environmental and epigenetic factors often play an important role in polygenic disorders. However, how such factors affect disease-specific tissues at the molecular level remains to be understood. Here, we address this in pulmonary arterial hypertens
Autor:
Yifei Miao, Shuai Mao, Silin Sa, Toshie Saito, Shoichiro Otsuki, Mingxia Gu, Neil Wary, Minzhe Guo, Lingli Wang, Marlene Rabinovitch, Michele Donato, Purvesh Khatri, Rebecca L. Harper
Publikováno v:
Sci Transl Med
Pulmonary arterial hypertension (PAH) is a progressive disorder leading to occlusive vascular remodeling. Current PAH therapies improve quality of life, but do not reverse structural abnormalities in the pulmonary vasculature. Here, we used high-thro
Publikováno v:
The Journal of Immunology. 206:27.16-27.16
Multiple myeloma is a cancer of disordered plasma cells. The disease poses significant challenges for clinical management where cytogenetic analysis, such as FISH (fluorescent in situ hybridization), was commonly used for diagnosis and prognosis. Bea
Publikováno v:
The Journal of Immunology. 206:27.17-27.17
Cell therapy development, including Chimeric antigen receptor (CAR)-T cells, involves many steps and requires processing on average 3 billion white blood cells or more. Automated large scale immunomagnetic cell isolation with high efficiency and thro