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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.

Autor: Giles K; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Berry DB; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Condello C; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Hawley RC; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Gallardo-Godoy A; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Bryant C; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Oehler A; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Elepano M; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Bhardwaj S; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Patel S; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Silber BM; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Guan S; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., DeArmond SJ; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Renslo AR; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco., Prusiner SB; Institute for Neurodegenerative Diseases (K.G., D.B.B., C.C., R.C.H., M.E., S.B., S.P., B.M.S., S.G., S.J.D., S.B.P); Small Molecule Discovery Center (A.G.-G., C.B., A.R.R.); and Departments of Neurology (K.G., C.C., R.C.H., B.M.S., S.B.P), Pharmaceutical Chemistry (A.G.-G., C.B., S.G., A.R.R.), Pathology (A.O., S.J.D.), Bioengineering and Therapeutic Sciences (B.M.S.), and Biochemistry and Biophysics (S.B.P.), University of California, San Francisco stanley.prusiner@ucsf.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 Oct; Vol. 355 (1), pp. 2-12. Date of Electronic Publication: 2015 Jul 29.