Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Sik Lok Lam"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1584-1592 (2023)
Expansions of short tandem repeats (STRs) are associated with approximately 50 human neurodegenerative diseases. These pathogenic STRs are prone to form non-B DNA structure, which has been considered as one of the causative factors for repeat expansi
Externí odkaz:
https://doaj.org/article/dbf76bafefef444ab7cae0d6d07f6e81
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 28263-28269 (2021)
Externí odkaz:
https://doaj.org/article/554f58709a164fd29af9a64695d1c4fe
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3633 (2021)
DNA methylation is a prevalent regulatory modification in prokaryotes and eukaryotes. N1-methyladenine (m1A) and N6-methyladenine (m6A) have been found to be capable of altering DNA structures via disturbing Watson–Crick base pairing. However, litt
Externí odkaz:
https://doaj.org/article/81e954356f3a403083282f94e5c9a694
Publikováno v:
International Journal of Biological Macromolecules. 201:607-615
Publikováno v:
FEBS Letters. 596:826-840
Minidumbbell (MDB) is a noncanonical DNA structure found to form in several pyrimidine-rich short tandem repeats associated with neurodegenerative diseases. The most recently reported MDB contains two pentaloops formed by ATTCT repeats. Here, we stud
Publikováno v:
ACS chemical neuroscience.
Expansions of ATTTT and ATTTC pentanucleotide repeats in the human genome are recently found to be associated with at least seven neurodegenerative diseases, including spinocerebellar ataxia type 37 (SCA37) and familial adult myoclonic epilepsy (FAME
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 28263-28269 (2021)
Minidumbbell (MDB) is a non-B DNA structure of which the thermodynamic stability is sensitive to a chemical environment such as pH, serving as a potential structural motif in constructing DNA-based molecular switches. This work aims to design thermod
Publikováno v:
The Journal of Physical Chemistry B. 124:5131-5138
Minidumbbell (MDB) is a newly discovered DNA structure formed by native sequences, which serves as a possible structural intermediate causing repeat expansion mutations in the genome and also a functional structural motif in constructing DNA-based mo
Publikováno v:
Chemical Communications. 56:10127-10130
Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular
Publikováno v:
International journal of biological macromolecules. 201
Expansion of d(GGCCTG)