Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sijin Luozhong"'
Autor:
Zhefan Yuan, Patrick McMullen, Sijin Luozhong, Pranab Sarker, Chenjue Tang, Tao Wei, Shaoyi Jiang
Publikováno v:
Chemical Science. 14:2033-2039
The hidden hydrophobicity of conventional polymers widely considered as hydrophilic is closely related to their immunogenicity when they are conjugated to immunogenic proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3cab1ab0f1e36169cbad8e662faac6b
https://doi.org/10.1039/d2sc07047b
https://doi.org/10.1039/d2sc07047b
Publikováno v:
Chemical Science. 13:10961-10970
The linkage of zwitterionic peptides containing alternating glutamic acid (E) and lysine (K) amino acids exhibits protective effects on protein drugs due to their high hydration capacity. Previously, short EK peptides covering the surface of a protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e52fc4c7f4709556767c7cd501d7735
https://doi.org/10.1039/d2sc03519g
https://doi.org/10.1039/d2sc03519g
Autor:
Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer, Shaoyi Jiang
Systemic delivery of mRNAs into disease neurons is first limited by the blood-brain-barrier (BBB). Leukocyte-derived extracellular vesicles (EVs) can cross the BBB at inflammatory sites, emerging as promising carriers to target the disease brain. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d704adad513c8f674f9615a7cb69a9b8
https://doi.org/10.1101/2022.12.07.518870
https://doi.org/10.1101/2022.12.07.518870
Publikováno v:
Journal of the American Chemical Society. 144(44)
Although recombinant adeno-associated viruses (AAVs) are considered low immunogenic and safe for gene delivery, the immunogenicity of capsids still represents a major obstacle to the readministration of AAV vectors. Here, we design an immunosuppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca6630387ab9921a7ecc7e78934ba7
https://pubmed.ncbi.nlm.nih.gov/36301739
https://pubmed.ncbi.nlm.nih.gov/36301739
Autor:
Sijin Luozhong, Zhefan Yuan, Tara Sarmiento, Yu Chen, Wenchao Gu, Caleb McCurdy, Wenting Gao, Ruoxin Li, Stephan Wilkens, Shaoyi Jiang
Publikováno v:
Nano letters. 22(20)
Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current delivery method relies on the drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections, an eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06407d98b3e04d8173201104f47cd31
https://pubmed.ncbi.nlm.nih.gov/36194390
https://pubmed.ncbi.nlm.nih.gov/36194390
Publikováno v:
Nano Today. 47:101674
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6a19f2216a9f824f372e72244a8c45
https://doi.org/10.1016/j.nantod.2022.101674
https://doi.org/10.1016/j.nantod.2022.101674
Publikováno v:
Journal of Microbiology and Biotechnology. 29:392-400
Chondroitin, the precursor of chondroitin sulfate, which is an important polysaccharide, has drawn significant attention due to its applications in many fields. In the present study, a heterologous biosynthesis pathway of chondroitin was designed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a119c71e6fd012a4f0d0416184c48cb
https://doi.org/10.4014/jmb.1810.10062
https://doi.org/10.4014/jmb.1810.10062
Autor:
Sijin Luozhong, Wenchao Gu, Chenjue Tang, Di Liu, Hsiang-Chieh Hung, Xiaohui Li, Kan Wu, Zhefan Yuan, Shaoyi Jiang
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 33(39)
Zwitterionic hydrogels have received great attention due to their excellent nonfouling and biocompatible properties, but they suffer from weak mechanical strength in the saline environments important for biomedical and engineering applications due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56efacd8f4232d045f7352c0ca91a0a
https://pubmed.ncbi.nlm.nih.gov/34387405
https://pubmed.ncbi.nlm.nih.gov/34387405
Autor:
Peng Zhang, Caroline Tsao, Liqian Niu, Sijin Luozhong, Shaoyi Jiang, Yu-Hong Cheng, Dianyu Dong, Patrick McMullen, Hsiang-Chieh Hung, Zhefan Yuan, Kan Wu
Publikováno v:
Bioconjugate chemistry. 31(7)
Glucagon-like peptide-1 (GLP-1) is of particular interest for treating type 2 diabetes mellitus (T2DM), as it induces insulin secretion in a glucose-dependent fashion and has the potential to facilitate weight control. However, native GLP-1 is a shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5539a8a3a859c9e5183c95713c902e7
https://pubmed.ncbi.nlm.nih.gov/32510929
https://pubmed.ncbi.nlm.nih.gov/32510929
Publikováno v:
Journal of microbiology and biotechnology. 29(3)
Chondroitin, the precursor of chondroitin sulfate, which is an important polysaccharide, has drawn significant attention due to its applications in many fields. In the present study, a heterologous biosynthesis pathway of chondroitin was designed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afa447eae16de1ecac6e6e7d81128d02
https://pubmed.ncbi.nlm.nih.gov/30691254
https://pubmed.ncbi.nlm.nih.gov/30691254