Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sijana H. Dzinic"'
Autor:
Adrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, Sijana H. Dzinic, Manasa Ravindra, Mathew Schneider, James Glassbrook, Carrie O’Connor, Zhanjun Hou, Seongho Kim, Jessica Back, Lisa Polin, Robert T. Morris, Aleem Gangjee, Heather Gibson, Larry H. Matherly
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have largely been unrealize
Externí odkaz:
https://doaj.org/article/02853bc9f796452ca78238c2e5dbf371
Autor:
Xinan Qiao, Jun Ma, Tristan Knight, Yongwei Su, Holly Edwards, Lisa Polin, Jing Li, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jian Wang, Hai Lin, Yue Wang, Liping Wang, Guan Wang, Jeffrey W. Taub, Yubin Ge
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 6, Pp 1-17 (2021)
Abstract About 25% of patients with acute myeloid leukemia (AML) harbor FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations and their prognosis remains poor. Gilteritinib is a FLT3 inhibitor approved by the US FDA for use in
Externí odkaz:
https://doaj.org/article/70d217bd11434be4bbb6948db97bb9fd
Autor:
Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Venetoclax is a promising agent in the treatment of acute myeloid leukemia, though its antileukemic activity is limited to combination therapies. Mcl-1 downregulation, Bim upregulation, and DNA damage have been identified as potential ways to enhance
Externí odkaz:
https://doaj.org/article/3e3e34e78f4b4b259f1f44a78a6c22ea
Autor:
Xinyu Li, Yongwei Su, Gerard Madlambayan, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jun Ma, Tristan Knight, Guan Wang, Yue Wang, Jay Yang, Jeffrey W. Taub, Hai Lin, Yubin Ge
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Induction therapy for patients with acute myeloid leukemia (AML) has remained largely unchanged for over 40 years, while overall survival rates remain unacceptably low, highlighting the need for new therapies. The PI3K/Akt pathway is constitutively a
Externí odkaz:
https://doaj.org/article/f997a12ee3164750a553d1a5d8fd8e8e
Autor:
Fangbing Liu, Hasini A. Kalpage, Deying Wang, Holly Edwards, Maik Hüttemann, Jun Ma, Yongwei Su, Jenna Carter, Xinyu Li, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Jeffrey W. Taub, Yubin Ge
Publikováno v:
Cancers, Vol 12, Iss 9, p 2400 (2020)
Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity an
Externí odkaz:
https://doaj.org/article/ac9f565c47084f5197544af874859c15
Publikováno v:
Cancer and Metastasis Reviews. 41:965-974
Epithelial-specific Maspin is widely known as a tumor suppressor. However, while the level of maspin expression is inversely correlated with tumor grade and stage, emerging clinical evidence shows a correlation between seemingly better differentiated
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Method Descriptions Molecular modeling and computational studies Enzyme expression and purification. In vitro enzymatic assays and Ki determinations In vivo efficacy trials with MIA PaCa-2 pancreatic cancer xenografts. Cytochrome c oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc08fe908fb7939bc9f8ad0ffe9cbc1
https://doi.org/10.1158/1535-7163.22505520
https://doi.org/10.1158/1535-7163.22505520
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4253307c713eb35fa04c2ec4fe8823be
https://doi.org/10.1158/1535-7163.c.6538104.v1
https://doi.org/10.1158/1535-7163.c.6538104.v1
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1
https://doi.org/10.1158/1535-7163.22505523.v1
Autor:
Yubin Ge, Jeffrey W. Taub, Yue Wang, Hai Lin, Lijing Zhao, Guan Wang, Kathryn White, Sijana H. Dzinic, Juiwanna Kushner, Lisa Polin, Holly Edwards, Tristan Knight, Xinan Qiao, Shoujing Zhao, Jun Ma
Purpose:To investigate the efficacy of the combination of the FLT3 inhibitors midostaurin or gilteritinib with the Bcl-2 inhibitor venetoclax in FLT3-internal tandem duplication (ITD) acute myeloid leukemia (AML) and the underlying molecular mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1c4c63610979404875496c09ea9a4d
https://doi.org/10.1158/1078-0432.c.6528239
https://doi.org/10.1158/1078-0432.c.6528239