Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Sihem Khelifa"'
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Abstract 5737: Evaluation of the relationship between target expression and in vivo anti-tumor efficacy of AZD9592, an EGFR/c-MET targeted bispecific antibody drug conjugate
Autor: Lara McGrath, Ying Zheng, Simon Christ, Christian C. Sachs, Sihem Khelifa, Claudia Windmüller, Steve Sweet, Yeoun Jin Kim, Daniel Sutton, Michal Sulikowski, Arthur Lewis, Ivan Inigo, Nicolas Floch, Edward Rosfjord, Fernanda Arnaldez, Frank Comer
Publikováno v: Cancer Research. 83:5737-5737
AZD9592 is a bispecific antibody drug conjugate (ADC) designed to deliver a topoisomerase 1 inhibitor (TOP1i) cytotoxic payload (AZ14170133) to tumor cells. AZD9592 selectively binds to epidermal growth factor receptor (EGFR) and c-MET, two cell surf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36096e1561106c476eff775f81cee6fc
https://doi.org/10.1158/1538-7445.am2023-5737
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2
Abstract P6-04-16: ART: Automated Region segmentation of Tumor on HER2-stained breast cancer tissue
Autor: Ansh Kapil, Anatoliy Shumilov, Philipp Wortmann, Sihem Khelifa, Jessica Chan, Michel Vandenberghe, Craig Barker, Mark Gustavson, Danielle Carroll, Hadassah Sade, Günter Schmidt
Publikováno v: Cancer Research. 83:P6-04
Background Computational pathology-based methods, eg, Quantitative Continuous Scoring (QCS) [Gustavson, SABCS 2020], are built to provide objective and quantitative methods to assess HER2 expression in breast cancer (BC). For accurate HER2 quantifica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc31585e4db5ccee9af46093ee173378
https://doi.org/10.1158/1538-7445.sabcs22-p6-04-16
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3
The morphologic spectrum of germline‐mutated BAP1‐inactivated melanocytic tumors includes lesions with conventional nevic melanocytes: A case report and review of literature
Autor: Kirsten Turchan, Ahmed K. Alomari, Sihem Khelifa, Timothy R. Wysozan
Publikováno v: Journal of Cutaneous Pathology. 46:852-857
Germline mutations in BRCA1-associated protein 1 (BAP1) are associated with several neoplasms, including BAP1-inactivated melanocytic tumors (BIMTs). BIMTs are classically described as biphenotypic melanocytic proliferations with BAP1-deficient large
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44256d87794d1c40d76b2c53997ccb60
https://doi.org/10.1111/cup.13525
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4
The Architecture of the Town Halls of the French Colonial Period in Algeria: The First Half of Nineteenth Century
Autor: Heddya Boulkroune, Sihem Khelifa-Rouaissia
Publikováno v: International Journal of Historical Archaeology. 21:420-432
The various civilizations which followed one another on the Algerian territory marked it by their presence. The architectural and urban production of each period displays its concepts and its styles, each rich with specific characteristics. The most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b2d13c4a437d10a0ba315cc9b7af583
https://doi.org/10.1007/s10761-016-0352-7
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5
HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma
Autor: Fadi Braiteh, Dimitrios Chondros, Mark M. Zalupski, Ping Jiang, Andrea Wang-Gillam, Jie Pu, Paul E. Oberstein, W. Wu, Paul S. Ritch, Tara Elisabeth Seery, Sihem Khelifa, Darren Sigal, William P. Harris, Nathan Bahary, Carrie Aldrich, Sunil R. Hingorani, Andrew Eugene Hendifar, Lei Zheng, Andrea J. Bullock
Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 36(4)
Purpose Metastatic pancreatic ductal adenocarcinoma is characterized by excessive hyaluronan (HA) accumulation in the tumor microenvironment, elevating interstitial pressure and impairing perfusion. Preclinical studies demonstrated pegvorhyaluronidas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b7fd3c05e08299516730e34fd3ca8c
https://pubmed.ncbi.nlm.nih.gov/29684975
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9
Hyaluronan assessment in tumor microenvironment using new affinity histochemistry assay and scoring method
Autor: Xionghua W. Wu, Carrie Aldrich, Junming Zhu, Paco Delgado, Sihem Khelifa, Michelle Quiroz, Jie Pu, Ping Jiang, Thomas Müller
Publikováno v: Journal of Clinical Oncology. 35:e23196-e23196
e23196 Background: Enzymatic degradation of hyaluronan (HA) by PEGylated recombinant human hyaluronidase PH20 (PEGPH20) induces a remodeling of the tumor microenvironment that impacts tumor behavior and response to therapy. Ventana Medical Systems, I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82cd3a1ada22734fa5fa28cb201187b0
https://doi.org/10.1200/jco.2017.35.15_suppl.e23196
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10
Randomized phase II study of PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) vs AG in patients (Pts) with untreated, metastatic pancreatic ductal adenocarcinoma (mPDA)
Autor: William P. Harris, Tara Elisabeth Seery, Jie Pu, Ping Jiang, Darren Sigal, Xionghua W. Wu, Sunil R. Hingorani, Andrew Eugene Hendifar, Lei Zheng, Mark M. Zalupski, Carrie Aldrich, Paul S. Ritch, Fadi Braiteh, Sihem Khelifa, Joaquina Baranda, Andrea J. Bullock, Nathan Bahary
Publikováno v: Journal of Clinical Oncology. 35:4008-4008
4008 Background: Hyaluronan (HA) accumulation in the tumor microenvironment produces elevated tumor pressure, vascular compression, and reduced drug delivery. PEGPH20 degrades HA, increasing the access and therapeutic index of anticancer agents. Meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9082effbe111af6c539749b389849526
https://doi.org/10.1200/jco.2017.35.15_suppl.4008
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