dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe

Autor: Joana S. Rodrigues, Miguel Chenlo, Susana B. Bravo, Sihara Perez-Romero, Maria Suarez-Fariña, Tomas Sobrino, Rebeca Sanz-Pamplona, Román González-Prieto, Manuel Narciso Blanco Freire, Ruben Nogueiras, Miguel López, Laura Fugazzola, José Manuel Cameselle-Teijeiro, Clara V. Alvarez

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-30 (2024)

Abstract The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an undifferentiated cancer with high mortality. We show here that depletion of the

Externí odkaz: https://doaj.org/article/34a05c85bda54bb8a024af079c17fe5c

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegalyResearch in context

Autor: Miguel Chenlo, Iria A. Rodriguez-Gomez, Ramon Serramito, Angela R. Garcia-Rendueles, Rocío Villar-Taibo, Eva Fernandez-Rodriguez, Sihara Perez-Romero, Maria Suarez-Fariña, Alfredo Garcia-Allut, Jose M. Cabezas-Agricola, Javier Rodriguez-Garcia, Pamela V. Lear, Rosa M. Alvarez-San Martin, Cristina Alvarez-Escola, Ignacio Bernabeu, Clara V. Alvarez

Publikováno v: EBioMedicine, Vol 43, Iss , Pp 537-552 (2019)

Background: Acromegaly is produced by excess growth hormone secreted by a pituitary adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with somatostatin analogs, fails in 25% of patients. There is no predictive fact

Externí odkaz: https://doaj.org/article/18978d90c30642d6a6cfc6c540bef848

The Inflammatory Pattern of Chronic Limb-Threatening Ischemia in Muscles: The TNF-α Hypothesis

Autor: Diego Caicedo, Clara V. Alvarez, Sihara Perez-Romero, Jesús Devesa

Publikováno v: Biomedicines, Vol 10, Iss 2, p 489 (2022)

Background: Vascular inflammation plays a crucial role in peripheral arterial disease (PAD), although the role of the mediators involved has not yet been properly defined. The aim of this work is to investigate gene expression and plasma biomarkers i

Externí odkaz: https://doaj.org/article/3197bcaac75a44ac974565e90232fbdd

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly

Autor: Maria Suarez-Fariña, Pamela V. Lear, Javier Rodríguez-García, Miguel Chenlo, A. García-Allut, Cristina Álvarez-Escolá, Ramon Serramito, Angela R. Garcia-Rendueles, Clara V. Alvarez, Sihara Perez-Romero, José Manuel Cabezas-Agrícola, Rosa M. Alvarez-San Martin, E. Fernández-Rodríguez, Rocío Villar-Taibo, Ignacio Bernabeu, I.A. Rodríguez-Gómez

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela

Background Acromegaly is produced by excess growth hormone secreted by a pituitary adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with somatostatin analogs, fails in 25% of patients. There is no predictive facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f454f7248f2a6e2cd8e80670d197c59b
http://hdl.handle.net/10486/688658

Pituitary cell activation and recruitment in hipothyroidism

Autor: Montserrat Garcia-Lavandeira, Sihara Perez-Romero, Clara V. Alvarez, Angela R. Garcia-Rendueles, Fernando Oroz

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b957a783229c8572c1c0899fe38432be
https://doi.org/10.1530/endoabs.56.p780