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Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.

Autor: de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Conomos MP; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Singh K; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Nicholson CJ; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jain D; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Hasbani NR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Jiang W; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lee S; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lino Cardenas CL; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lutz SM; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wong D; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young EP; Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Tcheandjieu C; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Hilliard AT; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Palo Alto Veterans Institute for Research, Palo Alto, CA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bielak LF; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Musharoff S; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Clarke SL; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Terry JG; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Heard-Costa N; Boston University School of Medicine, Boston, MA, USA.; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA., Selvaraj MS; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Li RH; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sun X; School of Public Health and Tropical Medicine, Department of Epidemiology, Tulane University, New Orleans, LA, USA.; College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA., Turner AW; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Stilp AM; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Khan A; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Rasheed A; Center For Non-Communicable Diseases, Karachi, Pakistan., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kral BG; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., McHugh CP; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Hodonsky C; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Saleheen D; Center For Non-Communicable Diseases, Karachi, Pakistan.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA., Herrington DM; Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Jacobs DR Jr; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, University of Washington, Seattle, WA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Wang FF; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Heiss G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Jun G; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Sigurslid HH; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Hall IM; Yale Center for Genomic Health, Yale School of Medicine, New Haven, CT, USA., Bensenor IM; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Broome J; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Crapo JD; Department of Medicine, National Jewish Health, Denver, CO, USA., Wilson JG; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Smith JA; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Vargas JD; Medstar Heart and Vascular Institute, Medstar Georgetown University Hospital, Washington, DC, USA., Mosquera JV; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Smith JD; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, University of Washington, Seattle, WA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA., Ryan KA; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Young KA; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Emery LS; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Bittencourt MS; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Budoff MJ; Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Montasser ME; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yu M; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Mahaney MC; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Mahamdeh MS; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Franceschini N; Department of Epidemiology, Gillings School of Global Public health, University of North Carolina, Chapel Hill, NC, USA., Lotufo PA; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Natarajan P; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wong Q; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Mathias RA; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehran R; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tracy RP; Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT, USA., Kim RW; Psomagen Inc., Rockville, MD, USA., Nelson SC; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kardia SLR; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Fuster V; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Mount Sinai Heart Center, New York, NY, USA., Napolioni V; Genomic And Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy., Zhao W; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Tian W; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Min YI; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Manning AK; Clinical and Translation Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Peloso G; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kelly TN; College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA., O'Donnell CJ; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Zapol WM; Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital, Boston, MA, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Becker LC; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Carr JJ; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Pereira AC; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil., Assimes TL; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Stitziel NO; Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Hokanson JE; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Laurie CA; 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Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Dec; Vol. 2 (12), pp. 1159-1172. Date of Electronic Publication: 2023 Dec 04.