Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Autor: McGinnis, R, Steinthorsdottir, V, Williams, NO, Thorleifsson, G, Shooter, S, Hjartardottir, S, Bumpstead, S, Stefansdottir, L, Hildyard, L, Sigurdsson, JK, Kemp, JP, Silva, GB, Thomsen, LCV, Jääskeläinen, T, Kajantie, E, Chappell, S, Kalsheker, N, Moffett, A, Hiby, S, Lee, WK, Padmanabhan, S, Simpson, NAB, Dolby, VA, Staines-Urias, E, Engel, SM, Haugan, A, Trogstad, L, Svyatova, G, Zakhidova, N, Najmutdinova, D, FINNPEC Consortium, GOPEC Consortium, Dominiczak, AF, Gjessing, HK, Casas, JP, Dudbridge, F, Walker, JJ, Pipkin, FB, Thorsteinsdottir, U, Geirsson, RT, Lawlor, DA, Iversen, AC, Magnus, P, Laivuori, H, Stefansson, K, Morgan, L, COLLABORATORS, Heinonen, S, Kere, J, Kivinen, K, Pouta, A, Macphail, S, Kilby, M, Habiba, M, Williamson, C, O'Shaughnessy, K, O'Brien, S, Cameron, A, Poston, L, Miedzybrodzka, Z, Redman, CWG, Farrall, M, Caulfield, M

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7abdaaa035f04d8c4f6b44daca99f63f

Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden.

Autor: Rögnvaldsson S; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík. srognvald@hi.is., Thorsteinsdóttir S; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Rigshospitalet, Copenhagen, Denmark., Syriopoulou E; Karolinska Institutet, Stockholm, Sweden; Red door analytics AB, Stockholm., Sverrisdottir I; Sahlgrenska University Hospital, Gothenburg., Turesson I; Skåne University Hospital, Lund., Eythorsson E; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík., Oskarsson JT; Faculty of Medicine, University of Iceland, Reykjavík., Long TE; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Skåne University Hospital, Lund., Vidarsson B; Landspítali - The National University Hospital of Iceland, Reykjavík., Onundarson PT; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík., Agnarsson BA; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík., Sigurdardottir M; Landspítali - The National University Hospital of Iceland, Reykjavík., Olafsson I; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík., Thorsteinsdottir I; Landspítali - The National University Hospital of Iceland, Reykjavík., Aspelund T; Faculty of Medicine, University of Iceland, Reykjavík., Gislason GK; Faculty of Medicine, University of Iceland, Reykjavík., Olafsson A; Faculty of Medicine, University of Iceland, Reykjavík., Sigurdsson JK; Faculty of Medicine, University of Iceland, Reykjavík., Hultcrantz M; Myeloma Service, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY., Durie BGM; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA., Harding S; Binding Site Group Ltd., Birmingham, United Kingdom., Bjorkholm M; Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm., Landgren O; Myeloma Program, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami., Love TJ; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík., Kristinsson SY; Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Landspítali - The National University Hospital of Iceland, Reykjavík.

Publikováno v: Haematologica [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2250-2255. Date of Electronic Publication: 2024 Jul 01.

Distinction between the effects of parental and fetal genomes on fetal growth.

Autor: Juliusdottir T; deCODE genetics/Amgen, Reykjavik, Iceland., Steinthorsdottir V; deCODE genetics/Amgen, Reykjavik, Iceland. valgerdur.steinthorsdottir@decode.is., Stefansdottir L; deCODE genetics/Amgen, Reykjavik, Iceland., Sveinbjornsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Ivarsdottir EV; deCODE genetics/Amgen, Reykjavik, Iceland., Thorolfsdottir RB; deCODE genetics/Amgen, Reykjavik, Iceland., Sigurdsson JK; deCODE genetics/Amgen, Reykjavik, Iceland., Tragante V; deCODE genetics/Amgen, Reykjavik, Iceland., Hjorleifsson KE; deCODE genetics/Amgen, Reykjavik, Iceland.; Department of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA, USA., Helgadottir A; deCODE genetics/Amgen, Reykjavik, Iceland., Frigge ML; deCODE genetics/Amgen, Reykjavik, Iceland., Thorgeirsson G; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Benediktsson R; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Sigurdsson EL; Development Centre for the Primary Care, Reykjavik, Iceland., Arnar DO; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Steingrimsdottir T; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Obstetrics and Gynecology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Jonsdottir I; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Immunology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland. kstefans@decode.is.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. kstefans@decode.is.

Publikováno v: Nature genetics [Nat Genet] 2021 Aug; Vol. 53 (8), pp. 1135-1142. Date of Electronic Publication: 2021 Jul 19.

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.

Autor: Bell S; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Rigas AS; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Magnusson MK; deCODE genetics/Amgen Inc., Reykjavik, Iceland. magnus.magnusson@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. magnus.magnusson@decode.is., Ferkingstad E; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Allara E; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Bjornsdottir G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Ramond A; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Halldorsson GH; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Paul DS; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Burgdorf KS; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Eggertsson HP; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Howson JMM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Thørner LW; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Kristmundsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Astle WJ; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Sigurdsson JK; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Vuckovic D; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Dinh KM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Surendran P; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Pedersen OB; Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark., Vidarsson B; The Laboratory in Mjodd, RAM, Reykjavik, Iceland., Jiang T; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Paarup HM; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Onundarson PT; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Laboratory Hematology, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland., Akbari P; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Lund SH; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Juliusson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Magnusson MI; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Frigge ML; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Oddsson A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali, the National University Hospital of Iceland, Reykjavik, Iceland., Kaptoge S; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Runarsson G; The Laboratory in Mjodd, RAM, Reykjavik, Iceland., Wood AM; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Jonsdottir I; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Hansen TF; Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Glostrup, Denmark.; Institute of Biological Psychiatry, Copenhagen University Hospital MHC Sct. Hans, Roskilde, Denmark.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Sigurdardottir O; Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland., Stefansson H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Rye D; Department of Neurology and Program in Sleep, Emory University School of Medicine, Atlanta, GA, USA., Peters JE; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Westergaard D; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Soranzo N; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Banasik K; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Ouwehand WH; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; UK National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Roberts DJ; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; Radcliffe Department of Medicine and National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.; UK National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, OX3 9BQ, UK., Sulem P; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Butterworth AS; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Gudbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Danesh J; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Brunak S; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Di Angelantonio E; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK. ed303@medschl.cam.ac.uk.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ed303@medschl.cam.ac.uk.; UK National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK. ed303@medschl.cam.ac.uk., Ullum H; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark. Henrik.Ullum@regionh.dk., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland. kstefans@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. kstefans@decode.is.

Publikováno v: Communications biology [Commun Biol] 2021 Feb 03; Vol. 4 (1), pp. 156. Date of Electronic Publication: 2021 Feb 03.

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.

Autor: Saevarsdottir S; deCODE genetics/Amgen, Reykjavik, Iceland. saedis.saevarsdottir@decode.is.; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. saedis.saevarsdottir@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. saedis.saevarsdottir@decode.is.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. saedis.saevarsdottir@decode.is., Olafsdottir TA; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Ivarsdottir EV; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Halldorsson GH; deCODE genetics/Amgen, Reykjavik, Iceland., Gunnarsdottir K; deCODE genetics/Amgen, Reykjavik, Iceland., Sigurdsson A; deCODE genetics/Amgen, Reykjavik, Iceland., Johannesson A; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Sigurdsson JK; deCODE genetics/Amgen, Reykjavik, Iceland., Juliusdottir T; deCODE genetics/Amgen, Reykjavik, Iceland., Lund SH; deCODE genetics/Amgen, Reykjavik, Iceland., Arnthorsson AO; deCODE genetics/Amgen, Reykjavik, Iceland., Styrmisdottir EL; deCODE genetics/Amgen, Reykjavik, Iceland., Gudmundsson J; deCODE genetics/Amgen, Reykjavik, Iceland., Grondal GM; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.; Center for Rheumatology Research, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Steinsson K; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.; Center for Rheumatology Research, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.; The Icelandic Medical Center, Mjodd, Reykjavik, Iceland., Alfredsson L; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Askling J; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Benediktsson R; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Bjarnason R; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Children's Medical Center, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Geirsson AJ; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Gudbjornsson B; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Center for Rheumatology Research, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Gudjonsson H; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Hjaltason H; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Neurology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Hreidarsson AB; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Klareskog L; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Kockum I; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Kristjansdottir H; Center for Rheumatology Research, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Love TJ; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; The Icelandic Medical Center, Mjodd, Reykjavik, Iceland.; Department of Science, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Ludviksson BR; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Olsson T; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Onundarson PT; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Hematology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Orvar KB; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Padyukov L; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Sigurgeirsson B; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Tragante V; deCODE genetics/Amgen, Reykjavik, Iceland., Bjarnadottir K; deCODE genetics/Amgen, Reykjavik, Iceland., Rafnar T; deCODE genetics/Amgen, Reykjavik, Iceland., Masson G; deCODE genetics/Amgen, Reykjavik, Iceland., Sulem P; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Melsted P; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Norddahl GL; deCODE genetics/Amgen, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Jonsdottir I; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland. kstefans@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. kstefans@decode.is.

Publikováno v: Nature [Nature] 2020 Aug; Vol. 584 (7822), pp. 619-623. Date of Electronic Publication: 2020 Jun 24.