Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Sigurdis Haraldsdottir"'
Autor:
GiWon Shin, Stephanie U. Greer, Erik Hopmans, Susan M. Grimes, HoJoon Lee, Lan Zhao, Laura Miotke, Carlos Suarez, Alison F. Almeda, Sigurdis Haraldsdottir, Hanlee P. Ji
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carc
Externí odkaz:
https://doaj.org/article/f712076aec7c479ebafdae1d3b8bdf16
Autor:
Olga Generalova, Mohana Roy, Evan Hall, Sumit A. Shah, Kristen Cunanan, Touran Fardeen, Brianna Velazquez, Gilbert Chu, Bianca Bruzzone, Anna Cabot, George A. Fisher, Sandy Srinivas, Alice C. Fan, Sigurdis Haraldsdottir, Heather A. Wakelee, Joel W. Neal, Sukhmani K. Padda, Tyler Johnson, Gregory M. Heestand, Robert W. Hsieh, Kavitha Ramchandran
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract Background Patient reported outcomes (PROs) have been associated with improved symptom management and quality of life in patients with cancer. However, the implementation of PROs in an academic clinical practice has not been thoroughly descr
Externí odkaz:
https://doaj.org/article/dbafc61564464849b330b75953721f50
Autor:
Ingrid P. Vogelaar, Stephanie Greer, Fan Wang, GiWon Shin, Billy Lau, Yajing Hu, Sigurdis Haraldsdottir, Rocio Alvarez, Dennis Hazelett, Peter Nguyen, Francesca P. Aguirre, Maha Guindi, Andrew Hendifar, Jessica Balcom, Anna Leininger, Beth Fairbank, Hanlee Ji, Megan P. Hitchins
Publikováno v:
Cancers, Vol 15, Iss 1, p 228 (2022)
Lynch syndrome (LS), caused by heterozygous pathogenic variants affecting one of the mismatch repair (MMR) genes (MSH2, MLH1, MSH6, PMS2), confers moderate to high risks for colorectal, endometrial, and other cancers. We describe a four-generation, 1
Externí odkaz:
https://doaj.org/article/a1576169436941d4b9bdb5ba310d3725
Publikováno v:
Hematology/Oncology Clinics of North America. 36:943-960
Germline genetic variants implicated in increasing lifetime risk of pancreatic cancer (PDAC) have been identified in ∼4% to 10% of cases. Clinical features such as family history have poor sensitivity in identifying carriers of these risk variants.
Autor:
Sigurdis Haraldsdottir, Thorunn Rafnar, Wendy L. Frankel, Sylvia Einarsdottir, Asgeir Sigurdsson, Heather Hampel, Petur Snaebjornsson, Gisli Masson, Daniel Weng, Reynir Arngrimsson, Birte Kehr, Ahmet Yilmaz, Stefan Haraldsson, Patrick Sulem, Tryggvi Stefansson, Peter G. Shields, Fridbjorn Sigurdsson, Tanios Bekaii-Saab, Pall H. Moller, Margret Steinarsdottir, Kristin Alexiusdottir, Megan Hitchins, Colin C. Pritchard, Albert de la Chapelle, Jon G. Jonasson, Richard M. Goldberg, Kari Stefansson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Lynch syndrome is characterized by predisposition to colorectal cancer and mutations in genes involved in mismatch repair. Here, the authors use whole genome sequencing and immunohistochemistry of mismatch repair proteins to show a high prevalence of
Externí odkaz:
https://doaj.org/article/892427e1e8434dbab0cf538d0c78f168
Autor:
Haukur Einarsson, Johanna Run Runarsdottir, Thordur Tryggvason, Petur Snaebjornsson, Agnes Smaradottir, Vigdis Stefansdottir, Asgeir Thoroddsen, Reynir Arngrimsson, Jon Gunnlaugur Jonasson, Sigurdis Haraldsdottir
Publikováno v:
Genetics in Medicine. 24:999-1007
Universal screening for Lynch syndrome (LS) on resected colorectal carcinomas (CRCs) and endometrial carcinomas (ECs) was implemented in Iceland in 2017 using immunohistochemistry (IHC) for mismatch repair (MMR) proteins. We examined the efficacy of
Autor:
Arna Kristin Andresdottir, Haukur Einarsson, Hildur Jonsdottir, Jon Gunnlaugur Jonasson, Einar Stefan Bjornsson, Sigurdis Haraldsdottir
Publikováno v:
Gastroenterology. 164:1314-1316.e1
Autor:
Hanlee P. Ji, Lan Zhao, Susan M. Grimes, Stephanie U. Greer, Carlos Suárez, Erik S. Hopmans, Alison Almeda, GiWon Shin, Hojoon Lee, Laura Miotke, Sigurdis Haraldsdottir
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Genome Medicine
Genome Medicine
Colorectal carcinomas (CRCs) which have lost DNA mismatch repair display hypermutability evident in a molecular phenotype called microsatellite instability (MSI). These mismatch repair deficient tumors are thought to lack widespread genomic instabili
Autor:
Kristen K. Ciombor, Yoanna Pumpalova, Christina Wu, Tanios Bekaii-Saab, Mohamad Bassam Sonbol, Jordan Berlin, Gregory B. Lesinski, Zhengjia Chen, Bassel F. El-Rayes, Ibrahim Halil Sahin, Amber Draper, Subir Goyal, Sigurdis Haraldsdottir, Satya Das, Daniel H. Ahn
Publikováno v:
Oncologist
Background Immune checkpoint inhibitor (ICI) therapy is highly effective in metastatic mismatch repair-deficient (MMR-D) colorectal cancer (CRC). In this study, we evaluated molecular and clinical predictors of ICI response in MMR-D CRC. Materials an
Autor:
Sigurdis Haraldsdottir
Publikováno v:
JCO precision oncology. 1