Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer

Autor: Qing Zhou, Samantha O. Perakis, Peter Ulz, Sumitra Mohan, Jakob M. Riedl, Emina Talakic, Sigurd Lax, Martin Tötsch, Gerald Hoefler, Thomas Bauernhofer, Martin Pichler, Armin Gerger, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher

Publikováno v: Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)

Abstract Background Bevacizumab, a monoclonal antibody against soluble VEGFA, is an approved and commonly administered anti-angiogenic drug in patients with metastasized colorectal cancer (mCRC). The survival benefit of anti-VEGF therapy in mCRC pati

Externí odkaz: https://doaj.org/article/fc254d7ec85e448b9fbac1d663e3b0b7

Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.

Autor: Verena Tiran, Stefanie Stanzer, Ellen Heitzer, Michael Meilinger, Christopher Rossmann, Sigurd Lax, Oleksiy Tsybrovskyy, Nadia Dandachi, Marija Balic

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175223 (2017)

A common symptom during late stage breast cancer disease is pleural effusion, which is related to poor prognosis. Malignant cells can be detected in pleural effusions indicating metastatic spread from the primary tumor site. Pleural effusions have be

Externí odkaz: https://doaj.org/article/dab9aee4402c43888242fe7455814733

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

Autor: Sumitra Mohan, Ellen Heitzer, Peter Ulz, Ingrid Lafer, Sigurd Lax, Martina Auer, Martin Pichler, Armin Gerger, Florian Eisner, Gerald Hoefler, Thomas Bauernhofer, Jochen B Geigl, Michael R Speicher

Publikováno v: PLoS Genetics, Vol 10, Iss 3, p e1004271 (2014)

Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic colorectal cancer (CRC). However, almost all patients with clinical response t

Externí odkaz: https://doaj.org/article/ca1ee54617a7403a9ad5c1ba8a23efa6

ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer – Update 2023

Autor: David Cibula, Maria Rosaria Raspollini, François Planchamp, Carlos Centeno, Cyrus Chargari, Ana Felix, Daniela Fischerová, Daniela Jahnn-Kuch, Florence Joly, Christhardt Kohler, Sigurd Lax, Domenica Lorusso, Umesh Mahantshetty, Patrice Mathevet, Mr Raj Naik, Remi A Nout, Ana Oaknin, Fedro Peccatori, Jan Persson, Denis Querleu, Sandra Rubio Bernabé, Maximilian P. Schmid, Artem Stepanyan, Valentyn Svintsitskyi, Karl Tamussino, Ignacio Zapardiel, Jacob Lindegaard

Publikováno v: Cibula, D, Rosaria Raspollini, M, Planchamp, F, Centeno, C, Chargari, C, Felix, A, Fischerová, D, Jahnn-Kuch, D, Joly, F, Kohler, C, Lax, S, Lorusso, D, Mahantshetty, U, Mathevet, P, Raj Naik, M, Nout, R A, Oaknin, A, Peccatori, F, Persson, J, Querleu, D, Rubio Bernabé, S, Schmid, M P, Stepanyan, A, Svintsitskyi, V, Tamussino, K, Zapardiel, I & Lindegaard, J 2023, ' ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer – Update 2023 ', Radiotherapy and Oncology, vol. 184, 109682 . https://doi.org/10.1016/j.radonc.2023.109682

Funding Information: The authors thank ESGO, ESTRO, and ESP for their support. The authors also thank the 155 international reviewers (physicians and patient representatives, see Appendix 2 in Online Supplemental File 2) for their valuable comments a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65f0323ffe81b41bb05a0de9ce3192b
https://pure.au.dk/portal/da/publications/esgoestroesp-guidelines-for-the-management-of-patients-with-cervical-cancer--update-2023(a7a7a4ad-5b3a-4fb0-8db3-a3c06ec7558b).html

Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Autor: Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer

PDF file - 95K, List of 68 genes, which, according to the COSMIC database, are frequently mutated in colorectal carcinoma (CRC) and analyzed in our study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b6d8d30c3e6a4af6e490764f2583e7
https://doi.org/10.1158/0008-5472.22398288