Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc.

Autor: José M Godoy Muñoz, Lasse Neset, Sigurbjörn Markússon, Sarah Weber, Oda C Krokengen, Aleksi Sutinen, Eleni Christakou, Andrea J Lopez, Clive R Bramham, Petri Kursula

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0300453 (2024)

The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and learning, stress regulation,

Externí odkaz: https://doaj.org/article/d6ab482ccff94e108f2968ea805e64c2

Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.

Autor: Erik I Hallin, Sigurbjörn Markússon, Lev Böttger, Andrew E Torda, Clive R Bramham, Petri Kursula

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251459 (2021)

Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms virus-like capsid structure

Externí odkaz: https://doaj.org/article/f34bcf4d31044cea8105ca392cd38f76

Structural Characterization of Functionally Important Chloride Binding Sites in the Marine

Autor: Sigurbjörn, Markússon, Jens G, Hjörleifsson, Petri, Kursula, Bjarni, Ásgeirsson

Publikováno v: Biochemistry. 61(20)

Enzyme stability and function can be affected by various environmental factors, such as temperature, pH, and ionic strength. Enzymes that are located outside the relatively unchanging environment of the cytosol, such as those residing in the periplas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36bb00f885d667418a1f90c084a8d014
https://pubmed.ncbi.nlm.nih.gov/36194497

Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function

Autor: Yuta Ishizuka, Tadiwos F. Mergiya, Rodolfo Baldinotti, Ju Xu, Erik I. Hallin, Sigurbjörn Markússon, Petri Kursula, Clive R. Bramham

Publikováno v: Neurochemical Research

Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed to function as an interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad01d49c08a007cc2acd012fc748278c
https://hdl.handle.net/11250/3001339

Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc

Autor: Petri Kursula, Andrew E. Torda, Sigurbjörn Markússon, Lev Böttger, Erik I. Hallin, Clive R. Bramham

Publikováno v: e0251459
PLOS ONE
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251459 (2021)
PLOS ONE 16(5), e0251459 (1-26) (2021). doi:10.1371/journal.pone.0251459

Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms virus-like capsid structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618f924d54b67ef2acab1edfee537d49
https://hdl.handle.net/11250/2991026