Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Siguazodan"'
Autor:
Mohammad Asif
Publikováno v:
Journal of Chemical Reviews. 1:66-77
In this work, some pyridazinones were studied for their cardioactive activity. These compounds showed significant cardio-active action with respect to the regular used drugs. However, it was found that the existence of the pyridazine ring is a crucia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2435ea51582e794ab7890498cd09df6
https://doi.org/10.33945/sami/jcr.2019.1.6677
https://doi.org/10.33945/sami/jcr.2019.1.6677
Publikováno v:
British Journal of Pharmacology. 173:2335-2351
Background and purpose We investigated the effectiveness of RPL554, a dual PDE3 and 4 enzyme inhibitor, on airway smooth muscle relaxation and compared it with that induced by salbutamol, ipratropium bromide, glycopyrrolate or their combination on br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e301e3e549978827368a562dac8f508d
https://doi.org/10.1111/bph.13512
https://doi.org/10.1111/bph.13512
Autor:
Christophe Faisy, Paul-André Risse, Emmanuel Guerot, Phillipe Devillier, Charles Advenier, Jean-Yves Fagon, Emmanuel Naline
Publikováno v:
Life Sciences. 79:1929-1935
Chronic exposure of human isolated bronchi to beta2-adrenergic agonists, especially fenoterol, potentiates smooth muscle contraction in response to endothelin-1 (ET-1), a peptide implicated in chronic inflammatory airway diseases. 5'-Cyclic adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1314449a2711a31ef21124064f2ff2b
https://doi.org/10.1016/j.lfs.2006.06.020
https://doi.org/10.1016/j.lfs.2006.06.020
Autor:
James I. Gillespie
Publikováno v:
BJU International. 93:1325-1332
Over the past few months Gillespie has published several papers in the BJU International investigating the overactive bladder and BOO, using novel models and theories. This next paper continues these concepts and shows that the mechanisms influencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb922c64ccf72d03057302371270958
https://doi.org/10.1111/j.1464-410x.2004.04840.x
https://doi.org/10.1111/j.1464-410x.2004.04840.x
Autor:
Bibhusana Borthakur, Tresa George, Dong Yan, Mark A. Giembycz, Hawazen BinMahfouz, Robert Newton
Publikováno v:
Molecular pharmacology. 87(1)
Glucocorticoids, also known as corticosteroids, induce effector gene transcription as a part of their anti-inflammatory mechanisms of action. Such genomic effects can be significantly enhanced by long-acting β2-adrenoceptor agonists (LABAs) and may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c018a4b0373cd7bcf15c311b0ed9f6
https://pubmed.ncbi.nlm.nih.gov/25324049
https://pubmed.ncbi.nlm.nih.gov/25324049
Autor:
Esteban J. Morcillo, Marc Bardou, Luc Rochette, Françoise Goirand, Philippe Devillier, Jean-Paul Dumas, Céline Rouget, Sandrine Marchand, Monique Dumas
Publikováno v:
Journal of Cardiovascular Pharmacology. 38:325-334
This study investigated the influence of NO, potassium (K+) channel blockade, and the phosphodiesterase inhibitors (PDEIs) theophylline (non-selective PDEI), siguazodan (PDE3I), rolipram (PDE4I), and zaprinast (PDE5I) on rat isolated main pulmonary a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18bbb375b2cd14a4c2834aecb0a7a62
https://doi.org/10.1097/00005344-200108000-00018
https://doi.org/10.1097/00005344-200108000-00018
Publikováno v:
European Journal of Pharmacology. 406:233-238
The present study was undertaken to investigate and compare responses to the cyclic nucleotide phosphodiesterase inhibitors siguazodan (type III, guanosine 3',5'-cyclic monophosphate (cGMP)-inhibited adenosine 3',5'-cyclic monophosphate (cAMP)), roli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6efc2d84166fe053267d9c2bb5b9b5f
https://doi.org/10.1016/s0014-2999(00)00501-x
https://doi.org/10.1016/s0014-2999(00)00501-x
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 13:231-239
The aim of this study was to investigate whether cyclic adenosine 3'5-monophosphate (cAMP) phosphodiesterase (PDE) activity is altered in monocytes from mild asthmatic subjects. Total cAMP PDE activity (pmol/min per mg protein) was significantly grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a773dab7803f5a25eea0dad9a85c1ce
https://doi.org/10.1006/pupt.2000.0248
https://doi.org/10.1006/pupt.2000.0248
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 13:141-147
Alveolar macrophages (AMsmall ef, Cyrillic) express considerable arginase activity which can be modulated by various mediators. As inhibitors of phosphodiesterase (PDE) play an increasing role in the treatment of chronic inflammatory and obstructive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c762f3a1cbd19ee8868cff6b8730cdf
https://doi.org/10.1006/pupt.2000.0240
https://doi.org/10.1006/pupt.2000.0240
Publikováno v:
Clinical & Experimental Allergy. 30:706-712
Background The type 4 phosphodiesterase (PDE) isoenzyme is the main isoenzyme of PDE involved in the control of adult mononuclear cell proliferation. Objective To establish whether PDE isoenzymes are present in umbilical cord blood mononuclear cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3290dbb4fcba67463eac7348da470b00
https://doi.org/10.1046/j.1365-2222.2000.00813.x
https://doi.org/10.1046/j.1365-2222.2000.00813.x