Výsledky vyhledávání - "Sigrun Smola-Hess"

The inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate superabsorber

Autor: Ronny Wegner, Gebhart Malchau, Sabine A. Eming, Hans Smola, Sigrun Smola-Hess, Thomas Krieg, Berenike Hartmann

Publikováno v: Biomaterials. 29:2932-2940

Excessive matrix metalloproteinase (MMP) levels have been observed in wound fluid of impaired healing wounds. This is thought to interfere with granulation tissue formation as newly formed extracellular matrix and cytokines are degraded and the wound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4f2d3e062867b5252748f9de65e069
https://doi.org/10.1016/j.biomaterials.2008.03.029

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E7 proteins from high- and low-risk human papillomaviruses bind to TGF-β-regulated Smad proteins and inhibit their transcriptional activity

Autor: Herbert Pfister, M Habig, Sigrun Smola-Hess, Vandana S Dole, Hans Smola, Rik Derynck

Publikováno v: Archives of Virology. 151:1961-1972

Human papillomaviruses (HPV) infect keratinocytes of skin and mucosa. Persistent infection can lead to the formation of benign tumors. In cases of high-risk HPV, such as HPV16 or 18, these may further progress to cancer. In order to support viral rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f15d3051c4280acf92f406c0b933c8
https://doi.org/10.1007/s00705-006-0768-1

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Inhibition of Nuclear Translocation of Nuclear Factor-κB Despite Lack of Functional IκBα Protein Overcomes Multiple Defects in Apoptosis Signaling in Human B-Cell Malignancies

Autor: Jürgen Wolf, Özlem Mani, Roman K. Thomas, Daniel Berenbrinker, Alexey Popov, Thomas Zander, Joachim L. Schultze, Martin L. Sos, Sigrun Smola-Hess

Publikováno v: Clinical Cancer Research. 11:8186-8194

Purpose: Defective apoptosis signaling is a typical feature of classic Hodgkin's lymphoma, multiple myeloma, and activated B-cell-like diffuse large B-cell lymphoma. In these malignancies, the transcription factor nuclear factor-κB (NF-κB) is a cri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998a252ec671f06c7afce0fac5b3e5a4
https://doi.org/10.1158/1078-0432.ccr-05-0224

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Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

Autor: Hans Smola, Sigrun Smola-Hess, Gail Martin, Pierre Shephard, Thomas Krieg, Georg Brunner

Publikováno v: The American Journal of Pathology. 164:2055-2066

In wound healing epidermal-dermal interactions are known to regulate keratinocyte proliferation and differentiation. To find out how fibroblasts respond to epithelial stimuli, we characterized fibroblasts in monolayer co-culture with keratinocytes. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e20a42973b346f61e2836d8d245e94b
https://doi.org/10.1016/s0002-9440(10)63764-9

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The Papillomavirus E2 Protein Binds to and Synergizes with C/EBP Factors Involved in Keratinocyte Differentiation

Autor: Herbert Pfister, Sigrun Smola-Hess, Dirk Hadaschik, Monika Ołdak, Korinna Hinterkeuser

Publikováno v: Journal of Virology. 77:5253-5265

The papillomavirus life cycle is closely linked to the differentiation program of the host keratinocyte. Thus, late gene expression and viral maturation are restricted to terminally differentiated keratinocytes. A variety of cellular transcription fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083bc32f6dd53fd2872633c929608efd
https://doi.org/10.1128/jvi.77.9.5253-5265.2003

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CD40L Induces Matrix-Metalloproteinase-9 but Not Tissue Inhibitor of Metalloproteinases-1 in Cervical Carcinoma Cells: Imbalance between NF-κB and STAT3 Activation

Autor: Herbert Pfister, Cornelia Mauch, Hans Smola, Dirk Hadaschik, Sigrun Smola-Hess, Thomas Krieg, Rolf Schnitzler

Publikováno v: Experimental Cell Research. 267:205-215

Matrix-metalloproteinases (MMPs) are essentially required for tumor cell invasion and metastasis. Production of precursor enzymes is regulated on transcriptional level, while activation of the pro-enzymes is tightly controlled by posttranscriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11556d286a5bf260f1189ab2e1acea5
https://doi.org/10.1006/excr.2001.5256

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Novel immunosuppressive properties of interleukin‐6 in dendritic cells: inhibition of NF‐κB binding activity and CCR7 expression

Autor: Jenny Pahne, Subramanya Hegde, Sigrun Smola-Hess

Publikováno v: The FASEB Journal. 18:1439-1441

Interleukin-6 (IL-6) is produced during bacterial and viral infections and by various malignant tumors. Here, we describe novel immunosuppressive properties of IL-6 in dendritic cells (DC). In the presence of GM-CSF, IL-4, and a maturation stimulus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ceba9ef349984595cd2c79170ae917d
https://doi.org/10.1096/fj.03-0969fje

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Interaction of Papillomaviral Oncoproteins with Cellular Factors

Autor: Herbert Pfister, Sigrun Smola-Hess

Publikováno v: Structure-Function Relationships of Human Pathogenic Viruses ISBN: 0306467682

Papillomavirus oncoproteins play a major role in the PV life cycle. Their main task is to overcome cell cycle control and to counteract immune surveillance. As they do not display any intrinsic enzymatic activity, they exert their function via protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::036ff599725c59201da97b94ea06098b
https://doi.org/10.1007/0-306-47650-9_14

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Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene products

Autor: Cornelia Mauch, Herbert Pfister, Sigrun Smola-Hess, Paola Zigrino, Hans Smola, Jenny Pahne

Publikováno v: The Journal of general virology. 86(Pt 5)

Matrix metalloproteinases (MMPs) degrade extracellular matrix. They are involved in cellular proliferation, migration, angiogenesis, invasion and metastasis. MT-1 MMP, a membrane-bound MMP, is expressed in carcinomas of the uterine cervix in vivo. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5369fbcb78fb656b09833b5c7ca818aa
https://pubmed.ncbi.nlm.nih.gov/15831939

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