Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sigrun M. Gustafsdottir"'
Autor:
Andries Blokzijl, Lei E Chen, Sigrun M Gustafsdottir, Jimmy Vuu, Gustav Ullenhag, Olle Kämpe, Ulf Landegren, Masood Kamali-Moghaddam, Håkan Hedstrand
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154214 (2016)
The diagnosis of malignant melanoma currently relies on clinical inspection of the skin surface and on the histopathological status of the excised tumor. The serum marker S100B is used for prognostic estimates at later stages of the disease, but anal
Externí odkaz:
https://doaj.org/article/13f7560764054bacb3ac9597061989c9
Autor:
Valgardur Sigurdsson, Saevar Ingthorsson, Bylgja Hilmarsdottir, Sigrun M Gustafsdottir, Sigridur Rut Franzdottir, Ari Jon Arason, Eirikur Steingrimsson, Magnus K Magnusson, Thorarinn Gudjonsson
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60798 (2013)
Branching morphogenesis is a mechanism used by many species for organogenesis and tissue maintenance. Receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR) and the sprouty protein family are believed to be critical regul
Externí odkaz:
https://doaj.org/article/7a8e2ff643864228badca2336c49eecb
Autor:
Sigrun M Gustafsdottir, Vebjorn Ljosa, Katherine L Sokolnicki, J Anthony Wilson, Deepika Walpita, Melissa M Kemp, Kathleen Petri Seiler, Hyman A Carrel, Todd R Golub, Stuart L Schreiber, Paul A Clemons, Anne E Carpenter, Alykhan F Shamji
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that "paints the cell" with as man
Externí odkaz:
https://doaj.org/article/8c40507e5fdb43ab9bb993e3733562bc
Autor:
Gunhild Mari Mælandsmo, Skarphéðinn Halldórsson, Saevar Ingthorsson, Bylgja Hilmarsdottir, Magnus K. Magnusson, Jennifer A. Kricker, Eirikur Briem, Thorarinn Gudjonsson, Sigrun M. Gustafsdottir
Publikováno v:
Cell Death & Disease
Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7179737db6fc01ff5948d0c628db541
https://hdl.handle.net/20.500.11815/307
https://hdl.handle.net/20.500.11815/307
Autor:
C. Suk-Yee Hon, Melissa A. Marton, Nicole E. Bodycombe, Sigrun M. Gustafsdottir, Vebjorn Ljosa, Paul A. Clemons, Vlado Dančík, Stuart L. Schreiber, Ellen Winchester, J. Anthony Wilson, Katherine L Sokolnicki, Joshua A. Bittker, Rajiv Narayan, Todd R. Golub, Wendy Winckler, Kejie Li, Jeremy R. Duvall, George B. Grant, Mathias Wawer, Aravind Subramanian, Mark-Anthony Bray, Melissa M. Kemp, Anne E. Carpenter, Bradley K. Taylor, Alykhan F. Shamji
Publikováno v:
Proceedings of the National Academy of Sciences. 111:10911-10916
High-throughput screening has become a mainstay of small-molecule probe and early drug discovery. The question of how to build and evolve efficient screening collections systematically for cell-based and biochemical screening is still unresolved. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c05190eb4d327c3eb9a28cd47962c91
https://doi.org/10.1073/pnas.1410933111
https://doi.org/10.1073/pnas.1410933111
Autor:
Shantanu Singh, Cathy L Hartland, Anne E. Carpenter, Blake Borgeson, Maria Kost-Alimova, Mark-Anthony Bray, Chadwick T. Davis, Christopher C. Gibson, Han Han, Sigrun M. Gustafsdottir
In morphological profiling, quantitative data are extracted from microscopy images of cells to identify biologically relevant similarities and differences among samples based on these profiles. This protocol describes the design and execution of expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626679e634093281be509c0c58680bff
Autor:
Tobias Bergström, Maria Sjögren, Xiao-Qun Zhang, Per-Henrik Edqvist, Björn Vennström, Sigrun M. Gustafsdottir, Mia Niklasson, Maud Forsberg, Karin Forsberg-Nilsson
Publikováno v:
Experimental Cell Research. 316:2779-2789
Platelet-derived growth factor (PDGF) is important in central nervous system (CNS) development, and aberrant expression of PDGF and its receptors has been linked to developmental defects and brain tumorigenesis. We previously found that neural stem a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae034bd557398c16ac255193529a9af7
https://doi.org/10.1016/j.yexcr.2010.07.009
https://doi.org/10.1016/j.yexcr.2010.07.009
Autor:
Claes Wadelius, Ulf Landegren, Alvaro Rada-Iglesias, Edith Schallmeiner, Joerg Schlingemann, Sigrun M. Gustafsdottir, Masood Kamali-Moghaddam
Publikováno v:
Proceedings of the National Academy of Sciences. 104:3067-3072
Protein-binding DNA sequence elements encode a variety of regulated functions of genomes. Information about such elements is currently in a state of rapid growth, but improved methods are required to characterize the sequence specificity of DNA-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30816d48c12c7c69ba61fc60965d0547
https://doi.org/10.1073/pnas.0611229104
https://doi.org/10.1073/pnas.0611229104
Autor:
Sigrun M. Gustafsdottir, Simon Fredriksson, Malik Merza, Ann Nordengrahn, Edith Schallmeiner, Ulf Landegren, Esteban Rivera, Per Wallgren
Publikováno v:
Clinical Chemistry. 52:1152-1160
Background: Nucleic acid amplification allows the detection of single infectious agents. Protein-based assays, although they provide information on ongoing infections, have substantially less detection sensitivity. Methods: We used proximity ligation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4823ca250aff039ec6575478a16f83fd
https://doi.org/10.1373/clinchem.2005.065847
https://doi.org/10.1373/clinchem.2005.065847
Autor:
Ulf Landegren, Simon Fredriksson, Mathias Howell, Malin Jarvius, Jonas Jarvius, Edith Schallmeiner, Ola Söderberg, Sigrun M. Gustafsdottir, Mats Gullberg
Publikováno v:
Analytical Biochemistry. 345:2-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d5ca1ceb24c95590eb076a16caa710
https://doi.org/10.1016/j.ab.2005.01.018
https://doi.org/10.1016/j.ab.2005.01.018