Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sigrun Häge"'
Autor:
Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff, Bert Klebl, Sabrina Wagner, Christina Wangen, Friedrich Hahn, Eileen Socher, Manfred Marschall
Publikováno v:
Cells, Vol 12, Iss 8, p 1162 (2023)
Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a multistage-regulated export pathway through the nuclear lami
Externí odkaz:
https://doaj.org/article/b8e09ac0be3d4d7183c73416683f4922
Autor:
Josephine Lösing, Sigrun Häge, Martin Schütz, Sabrina Wagner, Julia Wardin, Heinrich Sticht, Manfred Marschall
Publikováno v:
Cells, Vol 11, Iss 24, p 4030 (2022)
Herpesviruses replicate their genomes and assemble their capsids in the host cell nucleus. To progress towards morphogenesis in the cytoplasm, herpesviruses evolved the strategy of nuclear egress as a highly regulated process of nucleo-cytoplasmic ca
Externí odkaz:
https://doaj.org/article/58f245a709c14f5e96c168c61e7d47bd
Autor:
Friedrich Hahn, Christina Wangen, Sigrun Häge, Lars Herrmann, Alexandra Herrmann, Svetlana B. Tsogoeva, Manfred Marschall
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 115 (2022)
Starting in 2019, the spread of respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated pandemic of the corona virus disease (COVID-19) has led to enormous efforts in the development of medical countermeasures. Although innovative vaccines
Externí odkaz:
https://doaj.org/article/904bd36e07894e4b9758abafc7aff583
Autor:
Sigrun Häge, Manfred Marschall
Publikováno v:
Cells, Vol 11, Iss 11, p 1837 (2022)
Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of their large size; therefore, herpesviruses evolved
Externí odkaz:
https://doaj.org/article/8bf02b34026a4fcd86a66135f73a45c3
Publikováno v:
Viruses, Vol 14, Iss 5, p 1021 (2022)
The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50–p
Externí odkaz:
https://doaj.org/article/b03d8798fddc4540a8b62f4b78c780a6
Autor:
Sigrun Häge, Nicole Büscher, Victoria Pakulska, Friedrich Hahn, Annie Adrait, Steffi Krauter, Eva Maria Borst, Ursula Schlötzer-Schrehardt, Yohann Couté, Bodo Plachter, Manfred Marschall
Publikováno v:
Cells, Vol 10, Iss 11, p 3119 (2021)
The regulation of the nucleocytoplasmic release of herpesviral capsids is defined by the process of nuclear egress. Due to their large size, nuclear capsids are unable to traverse via nuclear pores, so that herpesviruses evolved to develop a vesicula
Externí odkaz:
https://doaj.org/article/46a30bdc73bf4f668ef99753bacfffe3
Autor:
Friedrich Hahn, Sigrun Häge, Alexandra Herrmann, Christina Wangen, Jintawee Kicuntod, Doris Jungnickl, Julia Tillmanns, Regina Müller, Kirsten Fraedrich, Klaus Überla, Hella Kohlhof, Armin Ensser, Manfred Marschall
Publikováno v:
Pathogens, Vol 10, Iss 9, p 1076 (2021)
Currently, human infections with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are accelerating the ongoing spread of the pandemic. Several innovative types of vaccines have already been developed, whereas effective options of
Externí odkaz:
https://doaj.org/article/b059dfdcbad14989be1d8b94db18bdef
Autor:
Jintawee Kicuntod, Sewar Alkhashrom, Sigrun Häge, Benedikt Diewald, Regina Müller, Friedrich Hahn, Peter Lischka, Heinrich Sticht, Jutta Eichler, Manfred Marschall
Publikováno v:
Viruses, Vol 13, Iss 3, p 462 (2021)
Herpesviral nuclear egress is a regulated process shared by all family members, ensuring the efficient cytoplasmic release of viral capsids. In the case of human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL
Externí odkaz:
https://doaj.org/article/9f708b6a453a43288dfff2b5708a73f9
Autor:
Sewar Alkhashrom, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall, Jutta Eichler
Publikováno v:
Viruses, Vol 13, Iss 3, p 471 (2021)
Nuclear egress is an essential process in the replication of human cytomegalovirus (HCMV), as it enables the migration of newly formed viral capsids from the nucleus into the cytoplasm. Inhibition of the HCMV core nuclear egress complex (core NEC), c
Externí odkaz:
https://doaj.org/article/ed4e6ba6b5fc4389ab99a2045db689a7
Autor:
Sigrun Häge, Eric Sonntag, Adriana Svrlanska, Eva Maria Borst, Anne-Charlotte Stilp, Deborah Horsch, Regina Müller, Barbara Kropff, Jens Milbradt, Thomas Stamminger, Ursula Schlötzer-Schrehardt, Manfred Marschall
Publikováno v:
Viruses, Vol 13, Iss 2, p 165 (2021)
Nuclear egress is a common herpesviral process regulating nucleocytoplasmic capsid release. For human cytomegalovirus (HCMV), the nuclear egress complex (NEC) is determined by the pUL50-pUL53 core that regulates multicomponent assembly with NEC-assoc
Externí odkaz:
https://doaj.org/article/90b6a819edab4e29a0c3c7b88eb63138