Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells

Autor: Sigridur A. Ásgeirsdóttir, Marcel H. J. Ruiters, Sabine Barnert, Grietje Molema, Jan A. A. M. Kamps, Jan Willem Kok, Regine Süss, Henriëtte W. M. Morselt, Joanna E. Adrian

Publikováno v: Journal of Controlled Release, 144(3), 341-349. Elsevier Bedrijfsinformatie b.v.

In non-phagocytic cells such as endothelial cells, processing of liposomes and subsequent release of drug content is often inefficient due to the absence of professional processing machinery, which limits pharmacological efficacy. We therefore develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c0ccd805e8848076e750e92abe47bc
https://doi.org/10.1016/j.jconrel.2010.03.003

Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function

Autor: Matijs van Meurs, Peter W. Mathieson, Simon C. Satchell, Rianne M. Jongman, Jan G. Zijlstra, Philipp Kümpers, Neng Fisheri Kurniati, Inge A. M. de Graaf, Francis M. Wulfert, Grietje Molema, Sigridur A. Ásgeirsdóttir, Peter Heeringa

Publikováno v: American journal of physiology-Renal physiology, 297(2), F272-F281. AMER PHYSIOLOGICAL SOC

van Meurs M, Kurniati NF, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kumpers P, Zijlstra JG, Heeringa P, Molema G. Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6279a7816429d4bd5a0b744cee5c44
https://doi.org/10.1152/ajprenal.00137.2009

Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium

Autor: Peter J. Zwiers, Grietje Molema, Sigridur A. Ásgeirsdóttir, Arjen H. Petersen, Hester I. Bakker, Henriëtte W. M. Morselt, Harry van Goor, Eric J. Steenbergen, Peter Heeringa, Cees G. M. Kallenberg, Karen van der Weide, Hendrik Moorlag, Jan A. A. M. Kamps

Publikováno v: Molecular Pharmacology, 72(1), 121-131. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Molecular Pharmacology, 72, 1, pp. 121-31
Molecular Pharmacology, 72, 121-31

Contains fulltext : 52320.pdf (Publisher’s version ) (Closed access) Glomerulonephritis represents a group of renal diseases with glomerular inflammation as a common pathologic finding. Because of the underlying immunologic character of these disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa63a5d712d852354da8c04f62f3d5a7
https://doi.org/10.1124/mol.107.034140

[Untitled]

Autor: Dietmar Vestweber, Gerben A. Koning, Sigridur A. Ásgeirsdóttir, Robbert J. Kok, Maaike Everts, Gert Storm, Dirk K. F. Meijer, Grietje Molema

Publikováno v: Pharmaceutical Research. 20:64-72

Purpose. Drug targeting to activated endothelial cells is now being explored as a new approach to interfere with chronic inflammation. This study compares a dexamethasone-anti-E-selectin immunoconjugate (dexa-AbEsel) with anti-E-selectin immunoliposo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1043a24e3ecc2c419b6c954c1695514
https://doi.org/10.1023/a:1022298725165

[Untitled]

Autor: Robbert J. Kok, Dirk K. F. Meijer, Sigridur A. Ásgeirsdóttir, Maaike Everts, Grietje Molema

Publikováno v: Pharmaceutical Research. 19:1730-1735

Purpose. For selective inhibition of endothelial cell activation in chronic inflammation, we have developed a dexamethasone-anti-E-selectin immunoconjugate. The present study was performed to evaluate the cellular handling of this immunoconjugate by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a3656d6c4d3f71ee70e2c14febe18e6
https://doi.org/10.1023/a:1020769716288