iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release

Autor: Lisa M. Henkel, Svenja Kankowski, Thiemo M. Moellenkamp, Nadine J. Smandzich, Sigrid Schwarz, Alessio Di Fonzo, Gudrun Göhring, Günter Höglinger, Florian Wegner

Publikováno v: Cells, Vol 12, Iss 2, p 223 (2023)

Multiple system atrophy of the parkinsonian type (MSA-P) is a rare, fatal neurodegenerative disease with sporadic onset. It is still unknown if MSA-P is a primary oligodendropathy or caused by neuronal pathophysiology leading to severe, α-synuclein-

Externí odkaz: https://doaj.org/article/1473e21a1d714024809d2525b9e91f13

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons.

Autor: Marvian, Amir T.^1,2,3,4 (AUTHOR) A.Tayaranian@med.uni-muenchen.de, Strauss, Tabea² (AUTHOR), Tang, Qilin² (AUTHOR), Tuck, Benjamin J.^5,6 (AUTHOR), Keeling, Sophie^5,6 (AUTHOR), Rüdiger, Daniel⁷ (AUTHOR), Mirzazadeh Dizaji, Negar⁸ (AUTHOR), Mohammad-Beigi, Hossein^9,10 (AUTHOR), Nuscher, Brigitte¹¹ (AUTHOR), Chakraborty, Pijush¹² (AUTHOR), Sutherland, Duncan S.¹⁰ (AUTHOR), McEwan, William A.^5,6 (AUTHOR), Köglsperger, Thomas^3,13 (AUTHOR), Zahler, Stefan⁷ (AUTHOR), Zweckstetter, Markus^12,14 (AUTHOR), Lichtenthaler, Stefan F.^2,4,15 (AUTHOR), Wurst, Wolfgang^2,4,16,17 (AUTHOR), Schwarz, Sigrid^2,18 (AUTHOR), Höglinger, Günter^2,3,4,19,20 (AUTHOR) Guenter.Hoeglinger@med.uni-muenchen.de

Publikováno v: Molecular Neurodegeneration. 12/31/2024, Vol. 19 Issue 1, p1-26. 26p.

Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling

Autor: Herbert Zimmermann, Florian Wegner, Sigrid Schwarz, Ute Roemuss, Javorina Milosevic, Annett Brandt, Johannes Schwarz, Alexander Storch, Antje Arnold

Publikováno v: Journal of Neurochemistry. 99:913-923

Isolation and propagation of neural stem cells derived from human brain tissue uniquely enables the study of human neurogenesis in vitro. In addition, ex vivo-expanded human neural stem/precursor cells (NPCs) may offer novel therapeutic strategies. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581981ab89d1cd4a197e4a834139269c
https://doi.org/10.1111/j.1471-4159.2006.04132.x

RGS9 Modulates Dopamine Signaling in the Basal Ganglia

Autor: Kwang H. Choi, Ching-Kang Chen, Robert R. Luedtke, Ralph J. DiLeone, Henry A. Lester, Eric J. Nestler, Laura J. Sim-Selley, Johannes Schwarz, Sigrid Schwarz, Melvin I. Simon, David W. Self, Michel Barrot, Abraham Kovoor, Marc N. Wein, Rachael L. Neve, Zia Ur Rahman, Dana E. Selley, Stephen J. Gold, Venetia Zachariou

Publikováno v: Neuron. 38(6):941-952

Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by serving as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an RGS subtype highly enriched in striatum, in modulating dopamine D2 recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f699e99762cfc6f4ebfa8d2b0960b3a

Modafinil in treatment of fatigue in multiple sclerosis

Autor: Udo A. Zifko, Monika Rupp, Harald T. Zipko, Eva M. Maida, Sigrid Schwarz

Publikováno v: Journal of Neurology. 249:983-987

Background Modafinil is a unique wake-promoting agent that is chemically distinct from traditional stimulants. Results of a placebo-controlled study showed it to improve fatigue in multiple sclerosis (MS) at a dose of 200 mg daily, but not at a dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::009596877117961100af91840101a5e7
https://doi.org/10.1007/s00415-002-0765-6