Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sigrid Nachtergaele"'
Autor:
Sigrid Nachtergaele
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001717 (2022)
The presence of m6A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to
Externí odkaz:
https://doaj.org/article/86b7e69a86de490f90bf39650e0be134
Autor:
Austin S. Draycott, Cassandra Schaening-Burgos, Maria F. Rojas-Duran, Loren Wilson, Leonard Schärfen, Karla M. Neugebauer, Sigrid Nachtergaele, Wendy V. Gilbert
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine sequencing (D-seq) for transcriptome-wide mapping of D with single-nucleotide reso
Externí odkaz:
https://doaj.org/article/cc529fc7d66c41c0bd44aeb22d3d881d
Autor:
Jie Lan, Nicholas Rajan, Martin Bizet, Audrey Penning, Nitesh K. Singh, Diana Guallar, Emilie Calonne, Andrea Li Greci, Elise Bonvin, Rachel Deplus, Phillip J. Hsu, Sigrid Nachtergaele, Chengjie Ma, Renhua Song, Alejandro Fuentes-Iglesias, Bouchra Hassabi, Pascale Putmans, Frédérique Mies, Gerben Menschaert, Justin J. L. Wong, Jianlong Wang, Miguel Fidalgo, Bifeng Yuan, François Fuks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces
Externí odkaz:
https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
Autor:
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
eLife, Vol 5 (2016)
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system i
Externí odkaz:
https://doaj.org/article/937ea17052e64dc28449bc38de2fd1a7
Autor:
Suresh Marada, Gemma Navarro, Ashley Truong, Daniel P Stewart, Angela M Arensdorf, Sigrid Nachtergaele, Edgar Angelats, Joseph T Opferman, Rajat Rohatgi, Peter J McCormick, Stacey K Ogden
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005473 (2015)
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences h
Externí odkaz:
https://doaj.org/article/4c423f7fb3a84caa9fc72b796bf9aaa3
Autor:
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
eLife, Vol 2 (2013)
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich do
Externí odkaz:
https://doaj.org/article/d808c19bbead4fb1b641ef3237212563
Autor:
Wendy V. Gilbert, Sigrid Nachtergaele
Publikováno v:
Annual Review of Biochemistry. 92
Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc206753d4924de760d81552bb8e98a7
https://doi.org/10.1146/annurev-biochem-052521-035949
https://doi.org/10.1146/annurev-biochem-052521-035949
Autor:
Maia Kinnebrew, Rachel E. Woolley, T. Bertie Ansell, Eamon F. X. Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S. P. Sansom, Douglas F. Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
Science Advances. 8
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecbac756ffd5793e4e4f0b3695b007b
https://doi.org/10.1126/sciadv.abm5563
https://doi.org/10.1126/sciadv.abm5563
Autor:
Cheng-Jie Ma, Sigrid Nachtergaele, Nitesh Kumar Singh, Nicholas Rajan, Gerben Menschaert, Miguel Fidalgo, Martin Bizet, Jianlong Wang, Bouchra Hassabi, Andrea Li Greci, Elise Bonvin, François Fuks, Pascale Putmans, Emilie Calonne, Bi-Feng Yuan, Diana Guallar, Alejandro Fuentes-Iglesias, Phillip J. Hsu, Renhua Song, Rachel Deplus, Audrey Penning, Justin J.-L. Wong, Jie Lan, Frédérique Mies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
NATURE COMMUNICATIONS
Nature Communications
Nature communications, 11 (1
NATURE COMMUNICATIONS
Nature Communications
Nature communications, 11 (1
Tet-enzyme-mediated 5-hydroxymethylation of cytosines in DNA plays a crucial role in mouse embryonic stem cells (ESCs). In RNA also, 5-hydroxymethylcytosine (5hmC) has recently been evidenced, but its physiological roles are still largely unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d865b84307caaf1748bb636ada22b193
https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
Autor:
Sigrid Nachtergaele, Yamuna Krishnan
Publikováno v:
The New England journal of medicine. 385(7)
A New Dimension in the RNA World Discoveries in noncoding RNA have shown it to be remarkably diverse in function and form and to have relevance in drug development. A recent study showed that some ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48eec7b90bd9eefa49f86f1eed845d6
https://pubmed.ncbi.nlm.nih.gov/34379930
https://pubmed.ncbi.nlm.nih.gov/34379930