Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Sigrid Mildenberger"'
Autor:
Virginie Dubourg, Gerald Schwerdt, Barbara Schreier, Michael Kopf, Sigrid Mildenberger, Ralf A. Benndorf, Michael Gekle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Endothelial cells (EC) are key players in vascular function, homeostasis and inflammation. EC show substantial heterogeneity due to inter-individual variability (e.g. sex-differences) and intra-individual differences as they originate from d
Externí odkaz:
https://doaj.org/article/d85fe54df585415eadc3aa04dfbb82dd
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2241 (2023)
(1) Background: Obesity is associated with hypertension because of endocrine dysregulation of the adrenergic and the renin–angiotensin–aldosterone systems. The epidermal growth factor receptor (EGFR) is an important signaling hub in the cardiovas
Externí odkaz:
https://doaj.org/article/82ad53fb64e64b18bf61a75e7d832853
Autor:
Barbara Schreier, Christian Stern, Virginie Dubourg, Alexander Nolze, Sindy Rabe, Sigrid Mildenberger, Claudia Wickenhauser, Michael Gekle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Vascular EGF receptors (EGFR) influence function and structure of arterial vessels. In genetic mouse models we described the role of vascular smooth muscle (VSMC) EGFR for proper physiological function and structure as well as for pathophysi
Externí odkaz:
https://doaj.org/article/239465dc77464e889819e565945224a9
Autor:
Michael Gekle, Sigrid Mildenberger
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1117 (2021)
Mineralocorticoids (e.g., aldosterone) support chronic inflammatory tissue damage, including glomerular mesangial injury leading to glomerulosclerosis. Furthermore, aldosterone leads to activation of the extracellular signal-regulated kinases (ERK1/2
Externí odkaz:
https://doaj.org/article/2ff0830bd40a455fbc0c0a0d58e4453e
Autor:
Andreas Benesic, Gerald Schwerdt, Isabell Hennemeier, Christoph Sauvant, Sigrid Mildenberger, Michael Gekle
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 4, Pp 1106-1116 (2014)
Background/Aims: Chronic renal proximal tubule dysfunction after therapy with the antineoplastic agent ifosfamide (IFO) is often attributed to the metabolite chloroacetaldehyde (CAA). Chronic IFO-nephropathy is reported to result in tubulointerstitia
Externí odkaz:
https://doaj.org/article/55684ea6c0bd4cd0bcbef156d82431e8
Autor:
Sigrid Mildenberger, Barbara Schreier, Alexander Nolze, Michael Gekle, Sindy Rabe, Christian Stern
Publikováno v:
Diabetologia
Aims/hypothesis Obesity causes type 2 diabetes leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major r
Autor:
Barbara Schreier, Virginie Dubourg, Stefanie Hübschmann, Sindy Rabe, Sigrid Mildenberger, Michael Gekle
Publikováno v:
Cellular and Molecular Life Sciences
The tyrosine kinase receptor EGFR and the G-protein-coupled receptor AT1R induce essential cellular responses, in part via receptor crosstalk with an unknown role in nuclear information transfer and transcription regulation. We investigated whether t
Autor:
Sigrid Mildenberger, Michael Gekle
Publikováno v:
Biomedicines
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1117, p 1117 (2021)
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1117, p 1117 (2021)
Mineralocorticoids (e.g., aldosterone) support chronic inflammatory tissue damage, including glomerular mesangial injury leading to glomerulosclerosis. Furthermore, aldosterone leads to activation of the extracellular signal-regulated kinases (ERK1/2
Autor:
Anja Wolf, Alexander Zipprich, Michael Gekle, S Pohl, Stefanie Hammer, Sindy Rabe, Sigrid Mildenberger, Barbara Schreier
Publikováno v:
British Journal of Pharmacology. 175:2956-2967
Background and purpose The mineralocorticoid receptor (MR) contributes to fibrosis in various tissues, and MR antagonists, like eplerenone, are used to prevent fibrosis. The role of MR antagonists in hepatic fibrosis and cirrhosis is unknown. Here, w
Autor:
Barbara Schreier, Julia Hupfeld, Danny Misiak, Maria Knyrim, Sigrid Mildenberger, Nicole Strätz, Katja Quarch, Stephanie Binas, Udo Kloeckner, Claudia Grossmann, Michael Gekle, Sindy Rabe
Publikováno v:
Cellular and Molecular Life Sciences
MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among others cardiac hypertrophy and atrial fibrillation. The aim of our study was to evaluate the impact of miR-221/222 on cardiac electrical remodeling. Cardiac miR expre