Výsledky vyhledávání - "Sigrid M A Swagemakers"

Akademický článek

A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis

Autor: Ikhwanuliman Putera, Benjamin Schrijver, P. Martijn Kolijn, Astrid C. van Stigt, Josianne C. E. M. ten Berge, Hanna IJspeert, Nicole M. A. Nagtzaam, Sigrid M. A. Swagemakers, Jan A. M. van Laar, Rupesh Agrawal, Saskia M. Rombach, P. Martin van Hagen, Rina La Distia Nora, Willem A. Dik

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two di

Externí odkaz: https://doaj.org/article/b0b00741299f4ad784a9dd558f407960

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Akademický článek

Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: A tool to stratify a high versus low risk of active tuberculosis?

Autor: Rina La Distia Nora, Ratna Sitompul, Marleen Bakker, Marjan A Versnel, Sigrid M A Swagemakers, Peter J van der Spek, Made Susiyanti, Lukman Edwar, Soedarman Sjamsoe, Gurmeet Singh, Rr Diah Handayani, Aniki Rothova, P Martin van Hagen, Willem A Dik

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0206073 (2018)

QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-

Externí odkaz: https://doaj.org/article/8298dbc53c5046e4bf7d049e35dac3a0

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Akademický článek

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106054 (2014)

BackgroundIn this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a

Externí odkaz: https://doaj.org/article/54e4a897fc8f4940a384b4aa95d8a42b

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Akademický článek

Bioinformatic meta-analysis reveals novel differentially expressed genes and pathways in sarcoidosis

Autor: Rogier T. A. van Wijck, Hari S. Sharma, Sigrid M. A. Swagemakers, Willem A. Dik, Hanna IJspeert, Virgil A. S. H. Dalm, Paul L. A. van Daele, P. Martin van Hagen, Peter J. van der Spek

Publikováno v: Frontiers in Medicine, Vol 11 (2024)

IntroductionSarcoidosis is a multi-system inflammatory disease of unknown origin with heterogeneous clinical manifestations varying from a single organ non-caseating granuloma site to chronic systemic inflammation and fibrosis. Gene expression studie

Externí odkaz: https://doaj.org/article/f8a6d8e6b3d74c478ef8b365b23c0637

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Akademický článek

Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

Autor: Els Moltzer, Luuk te Riet, Sigrid M A Swagemakers, Paula M van Heijningen, Marcel Vermeij, Richard van Veghel, Angelique M Bouhuizen, Joep H M van Esch, Stephanie Lankhorst, Natasja W M Ramnath, Monique C de Waard, Dirk J Duncker, Peter J van der Spek, Ellen V Rouwet, A H Jan Danser, Jeroen Essers

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23411 (2011)

Medial degeneration is a key feature of aneurysm disease and aortic dissection. In a murine aneurysm model we investigated the structural and functional characteristics of aortic wall degeneration in adult fibulin-4 deficient mice and the potential t

Externí odkaz: https://doaj.org/article/a6d2781360ab45bdb123a75a928f35cd

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Akademický článek

A new strategy to identify and annotate human RPE-specific gene expression.

Autor: Judith C Booij, Jacoline B ten Brink, Sigrid M A Swagemakers, Annemieke J M H Verkerk, Anke H W Essing, Peter J van der Spek, Arthur A B Bergen

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e9341 (2010)

BACKGROUND: To identify and functionally annotate cell type-specific gene expression in the human retinal pigment epithelium (RPE), a key tissue involved in age-related macular degeneration and retinitis pigmentosa. METHODOLOGY: RPE, photoreceptor an

Externí odkaz: https://doaj.org/article/7b2ff2bae1d14e89b4c15118456a6dcd

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Akademický článek

Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants

Autor: Johanna L. Heinz, Sigrid M. A. Swagemakers, Joanna von Hofsten, Marie Helleberg, Michelle M. Thomsen, Kerstin De Keukeleere, Joke H. de Boer, Tomas Ilginis, Georges M. G. M. Verjans, Peter M. van Hagen, Peter J. van der Spek, Trine H. Mogensen

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

PurposeHerpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cause a variety

Externí odkaz: https://doaj.org/article/2755a6e1e135421ea6420d24946ac46e

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