Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sigrid Keipert"'
Autor:
Norbert Schmees, Thomas Ritter, Heike Schäcke, Sigrid Knapp, Jun Yang, Natasa Orlic, Ljijana Otasevic, Maurice de Ruijter, Sigrid Keipert, Uwe Pleyer
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 243:450-455
New insights into the molecular mechanisms of corticosteroid-mediated actions have revealed new substances, such as selective glucocorticoid receptor agonists (SEGRA), for the treatment of inflammatory diseases. We set out to evaluate the effect of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213c088463fbfa2d2c8ef50d7b0c9a62
https://doi.org/10.1007/s00417-004-0991-y
https://doi.org/10.1007/s00417-004-0991-y
Autor:
Telse Richter, Sigrid Keipert
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 58:137-143
The components of a carrier formulation can interact with an added drug as well as with the membrane surface they were applied on. Therefore, they can influence permeability of the membrane and permeation of the drug. The particular membrane structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac890bf9541059cab430c02fb2c2627e
https://doi.org/10.1016/j.ejpb.2004.03.010
https://doi.org/10.1016/j.ejpb.2004.03.010
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:455-468
In vitro permeation studies of drugs across biological barriers are promising tools for estimating the quality and quantity of drug transport in vivo. The objective of this work was to compare the permeability of the hydrophilic model drug pilocarpin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aceb4c4ca7c93bab2d1945c356ca69e
https://doi.org/10.1089/10807680260362731
https://doi.org/10.1089/10807680260362731
Autor:
Sven Gärtner, Sigrid Keipert, Uwe Pleyer, Christian Hartmann, Martina Scholz, Stephan Schründer
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:177-183
Excimer laser photorefractive keratectomy (PRK) is a well-established procedure which is frequently applied to correct myopia. Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22251c5d5a6e22353358d0013fc31207
https://doi.org/10.1089/108076802317373923
https://doi.org/10.1089/108076802317373923
Autor:
A. Haβe, Sigrid Keipert
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 43:179-183
Water-continuous microemulsions for ocular application were developed and the physico-chemical parameters characterized. These microemulsions have favourable features for ocular use. They show an acceptable physico-chemical behaviour, especially pH v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c240749688a95bb8073512870b074f74
https://doi.org/10.1016/s0939-6411(96)00036-7
https://doi.org/10.1016/s0939-6411(96)00036-7
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 19(2)
The efficacy of mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), in high risk keratoplasties and ocular immune-mediated diseases has been shown in recent years. As peroral administration of MMF can cause various side effects, topica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6c895be12ad5d35488b52f1dfdb1e9
https://pubmed.ncbi.nlm.nih.gov/12804063
https://pubmed.ncbi.nlm.nih.gov/12804063
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 52(2)
We tested a high-water-content hydrophilic microemulsion (ME 1) and a low-water-content lipophilic microemulsion (ME 2) for their suitability for use in dermatology, in general, and as alternative hydrocortisone (HC) vehicles, in particular. The lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c708e8e8e6d7ccb02e4466aa3cbe544c
https://pubmed.ncbi.nlm.nih.gov/11522477
https://pubmed.ncbi.nlm.nih.gov/11522477
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 15(5)
The aim of the present study has been to develop aqueous Thalidomide (THA) eye drops in order to minimize systemic side effects and to improve bioavailability following topical application. Cyclodextrins (CDs), suitable vehicles to improve aqueous so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c931157147d32f7e58e9293b2d18bbad
https://pubmed.ncbi.nlm.nih.gov/10530704
https://pubmed.ncbi.nlm.nih.gov/10530704
Autor:
Sigrid Keipert, Matthias Oechsner
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 47(2)
For the treatment of dry-eye-syndrome preparations containing polymers as active agents are used. Polyacrylic acid (PAA) is a well known mucoadhesive polymer. For ocular use, however, the very high viscous gel systems can cause irritation post applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59050769a005313a97c427dd82dc8111
https://pubmed.ncbi.nlm.nih.gov/10234534
https://pubmed.ncbi.nlm.nih.gov/10234534
Autor:
Burkhard Siefert, Sigrid Keipert
Publikováno v:
Journal of pharmaceutical sciences. 86(6)
Interactions in aqueous solution between pilocarpine hydrochloride (P-HCl), a rather hydrophilic drug with good water solubility, and various cyclodextrins (CDs) were described recently. To assess the influence of CDs on the diffusion behavior of pil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ace8572de584dcf39124c398683504
https://pubmed.ncbi.nlm.nih.gov/9188054
https://pubmed.ncbi.nlm.nih.gov/9188054