Low sleep quality in major depressive disorder is associated with thinning and decreased functional connectivity of the insular cortex

Autor: Niklaus Denier, Sigrid Breit, Leila M. Soravia, Sebastian Walther, Nicolas Mertse, Lukas Krone, Andrea Federspiel, Roland Wiest, Tobias Bracht

Publikováno v: Journal of Affective Disorders Reports, Vol 16, Iss , Pp 100744- (2024)

Sleep disturbances are common in depression, but their neurobiological correlates are poorly understood. Recent evidence suggests links between insula dysfunction and sleep dysregulation. This study aimed to explore the association of sleep quality a

Externí odkaz: https://doaj.org/article/1b51fd3adf674fd4993d12c8402bd7ef

Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression

Autor: Niklaus Denier, Sebastian Walther, Sigrid Breit, Nicolas Mertse, Andrea Federspiel, Agnes Meyer, Leila M. Soravia, Meret Wallimann, Roland Wiest, Tobias Bracht

Publikováno v: NeuroImage: Clinical, Vol 38, Iss , Pp 103404- (2023)

Introduction:: Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This

Externí odkaz: https://doaj.org/article/97372d20f6d94e1dbb7a13fa073697da

Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

Autor: Tobias Bracht, Nicolas Mertse, Sebastian Walther, Karin Lüdi, Sigrid Breit, Andrea Federspiel, Roland Wiest, Niklaus Denier

Publikováno v: NeuroImage: Clinical, Vol 34, Iss , Pp 102961- (2022)

The ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC) are essential for experiencing pleasure and initiating motivated behaviour. The VTA, NAcc, and PFC are connected through the medial forebrain bundle (MFB). In hum

Externí odkaz: https://doaj.org/article/9c582529078d493cb85191eb33910194

White matter integrity and pro-inflammatory cytokines as predictors of antidepressant response in MDD

Autor: Sigrid Breit, Elena Mazza, Sara Poletti, Francesco Benedetti

Introduction Major depressive disorder (MDD) often involves immune dysregulation with high peripheral levels of pro-inflammatory cytokines that might have an impact on the clinical course and treatment response. Moreover, MDD patients show brain volu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e71b790c5da93c95f15ac49c7d11f20

Psychopharmacological treatment is not associated with reduced suicide ideation and reattempts in an observational follow-up study of suicide attempters

Autor: Konrad Michel, Anja Gysin-Maillart, Sebastian Walther, Anastasia Pavlidou, Sigrid Breit

Publikováno v: Michel, Konrad; Gysin-Maillart, Anja; Breit, Sigrid; Walther, Sebastian; Pavlidou, Anastasia (2021). Psychopharmacological treatment is not associated with reduced suicide ideation and reattempts in an observational follow-up study of suicide attempters. Journal of psychiatric research, 140, pp. 180-186. Elsevier 10.1016/j.jpsychires.2021.05.068

Background Disorders of mental health are major risk factors for suicidal behavior and require adequate treatment. However, the effect of psychotropic medication on suicidal behavior is unclear. Methods The 120 participants in a randomized clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6ee200a99fd6596ee33a2a8deafa23
https://doi.org/10.1016/j.jpsychires.2021.05.068