Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sigrid A. Langhans"'
Autor:
Xuyi Yue, Erik Stauff, Shriya Boyapati, Sigrid A. Langhans, Wenqi Xu, Sokratis Makrogiannis, Uchenna J. Okorie, Azubuike M. Okorie, Vinay V. R. Kandula, Heidi H. Kecskemethy, Rahul M. Nikam, Lauren W. Averill, Thomas H. Shaffer
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 685 (2024)
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral nerve sheath tumors (MPNSTs) with a
Externí odkaz:
https://doaj.org/article/019e695d74aa4ceb870e96c56e0bb5e7
Autor:
Zhiqin Li, Sigrid A. Langhans
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
After leukemia, tumors of the brain and spine are the second most common form of cancer in children. Despite advances in treatment, brain tumors remain a leading cause of death in pediatric cancer patients and survivors often suffer from life-long co
Externí odkaz:
https://doaj.org/article/3bb90ff22f5843d7aab6d6786b155c61
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
The development of therapies aimed at leukemia has progressed substantially in the past years but childhood acute myeloid leukemia (AML) remains one of the most challenging cancers to treat. Genomic profiling of AML has greatly enhanced our understan
Externí odkaz:
https://doaj.org/article/39ec02363f734c628317d30a150c2747
Autor:
Sigrid A. Langhans
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Drug development is a lengthy and costly process that proceeds through several stages from target identification to lead discovery and optimization, preclinical validation and clinical trials culminating in approval for clinical use. An important ste
Externí odkaz:
https://doaj.org/article/b42f5818b2ae4441a7ab91c802cfa397
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245a1bc885463a3778e22f8e39c620b6
https://doi.org/10.1007/978-1-0716-2914-7_22
https://doi.org/10.1007/978-1-0716-2914-7_22
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2614
Our increased understanding of how a cell's microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures for drug discovery. Particularly, scaffold-based 3D cultures are expected to recapitulate in vivo tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d4aa9f34a863acb3bc4d0b5a59332d3
https://pubmed.ncbi.nlm.nih.gov/36587136
https://pubmed.ncbi.nlm.nih.gov/36587136
Autor:
Arabinda K. Choudhary, Sigrid A. Langhans, Xuyi Yue, Bishnuhari Paudyal, Rahul Nikam, Vinay Kandula, Lauren W. Averill
Publikováno v:
Pediatric Radiology. 51:966-970
Abusive head trauma (AHT) is a leading cause of mortality and morbidity in child abuse, with a mortality rate of approximately 25%. In survivors, the prognosis remains dismal, with high prevalence of cerebral palsy, epilepsy and neuropsychiatric diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5c13a734762feaf48a7ed60bc4352b
https://doi.org/10.1007/s00247-021-04995-z
https://doi.org/10.1007/s00247-021-04995-z
Autor:
Rahul M. Nikam, Heidi H. Kecskemethy, Vinay V. R. Kandula, Lauren W. Averill, Sigrid A. Langhans, Xuyi Yue
Publikováno v:
International Journal of Molecular Sciences. 24:4463
Abusive head trauma (AHT) is a serious traumatic brain injury and the leading cause of death in children younger than 2 years. The development of experimental animal models to simulate clinical AHT cases is challenging. Several animal models have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d963f72ec664ac3af79834e97d94eb68
https://doi.org/10.3390/ijms24054463
https://doi.org/10.3390/ijms24054463
Autor:
Xuyi, Yue, Rahul M, Nikam, Heidi H, Kecskemethy, Vinay V R, Kandula, Stephen J, Falchek, Lauren W, Averill, Sigrid A, Langhans
Publikováno v:
Journal of visualized experiments : JoVE. (175)
The kynurenine pathway (KP) is a primary route for tryptophan metabolism. Evidence strongly suggests that metabolites of the KP play a vital role in tumor proliferation, epilepsy, neurodegenerative diseases, and psychiatric illnesses due to their imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f65b4281def646e71d2a156e16ab6b5
https://pubmed.ncbi.nlm.nih.gov/34633385
https://pubmed.ncbi.nlm.nih.gov/34633385
Publikováno v:
Molecular Neurobiology. 56:7557-7571
The Na,K-ATPase, consisting of a catalytic α-subunit and a regulatory β-subunit, is a ubiquitously expressed ion pump that carries out the transport of Na+ and K+ across the plasma membranes of most animal cells. In addition to its pump function, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc45944943afceb7bd18252d5e591d7
https://doi.org/10.1007/s12035-019-1592-4
https://doi.org/10.1007/s12035-019-1592-4