Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sigrid A Langhans"'
Autor:
Zhiqin eLi, Sigrid A Langhans
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 3 (2015)
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a re
Externí odkaz:
https://doaj.org/article/68f428cc69fb4528a37712722a3855ce
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Traditional two-dimensional (2D) cell culture systems have contributed tremendously to our understanding of cancer biology but have significant limitations in mimicking in vivo conditions such as the tumor microenvironment. In vitro, three-dimensiona
Externí odkaz:
https://doaj.org/article/8be7b34295fe45d99609436441a9575b
Autor:
Alisa eLitan, Sigrid A Langhans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Increasing evidence suggests that ion channels and pumps not only regulate membrane potential, ion homeostasis, and electric signaling in excitable cells but also play important roles in cell proliferation, migration, apoptosis and differentiation. C
Externí odkaz:
https://doaj.org/article/587c875b6524472aad3ff334f4b9d72c
Autor:
Stephan eLindsey, Sigrid A Langhans
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Epithelial-mesenchymal transition (EMT) and cell transformation have been well-documented in multiple cancer cell models and are believed to be one of the earliest events in tumor progression. Genetic and epigenetic modifications shift cells toward e
Externí odkaz:
https://doaj.org/article/e8575b09439b4472bb3c3b093ae5410a
Autor:
Seung Joon Lee, Stephan Lindsey, Bruce Graves, Soonmoon Yoo, James M Olson, Sigrid A Langhans
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71455 (2013)
Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the e
Externí odkaz:
https://doaj.org/article/129336d96d4d43e9837f5b2c33f498f3
Autor:
Xuyi Yue, Erik Stauff, Shriya Boyapati, Sigrid A. Langhans, Wenqi Xu, Sokratis Makrogiannis, Uchenna J. Okorie, Azubuike M. Okorie, Vinay V. R. Kandula, Heidi H. Kecskemethy, Rahul M. Nikam, Lauren W. Averill, Thomas H. Shaffer
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 685 (2024)
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral nerve sheath tumors (MPNSTs) with a
Externí odkaz:
https://doaj.org/article/019e695d74aa4ceb870e96c56e0bb5e7
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245a1bc885463a3778e22f8e39c620b6
https://doi.org/10.1007/978-1-0716-2914-7_22
https://doi.org/10.1007/978-1-0716-2914-7_22
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2614
Our increased understanding of how a cell's microenvironment influences its behavior has fueled an interest in three-dimensional (3D) cell cultures for drug discovery. Particularly, scaffold-based 3D cultures are expected to recapitulate in vivo tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d4aa9f34a863acb3bc4d0b5a59332d3
https://pubmed.ncbi.nlm.nih.gov/36587136
https://pubmed.ncbi.nlm.nih.gov/36587136
Autor:
Sigrid A. Langhans
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Drug development is a lengthy and costly process that proceeds through several stages from target identification to lead discovery and optimization, preclinical validation and clinical trials culminating in approval for clinical use. An important ste
Externí odkaz:
https://doaj.org/article/b42f5818b2ae4441a7ab91c802cfa397
Autor:
Arabinda K. Choudhary, Sigrid A. Langhans, Xuyi Yue, Bishnuhari Paudyal, Rahul Nikam, Vinay Kandula, Lauren W. Averill
Publikováno v:
Pediatric Radiology. 51:966-970
Abusive head trauma (AHT) is a leading cause of mortality and morbidity in child abuse, with a mortality rate of approximately 25%. In survivors, the prognosis remains dismal, with high prevalence of cerebral palsy, epilepsy and neuropsychiatric diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5c13a734762feaf48a7ed60bc4352b
https://doi.org/10.1007/s00247-021-04995-z
https://doi.org/10.1007/s00247-021-04995-z