Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sigrid, Dubois"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We completed clinical trials of rhIL-15 by bolus, subcutaneous, and continuous intravenous infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a 38-fold increase in 10- day number of circulating NK cells, a 358-fold increase in CD56bri
Externí odkaz:
https://doaj.org/article/7f1f7a8064824eb1bf30995942c9b2b8
Autor:
Thomas A. Waldmann, Bonita R. Bryant, Nancy Beltran, Jennifer Hsu-Albert, Jürgen R. Müller, Kevin C. Conlon, Sigrid Dubois
The cytokine IL15 is required for survival and activation of natural killer (NK) cells as well as expansion of NK-cell populations. Here, we compare the effects of continuous IL15 infusions on NK-cell subpopulations in cancer patients. Infusions affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76196a5658cb76d71aa0d6d32376773e
https://doi.org/10.1158/2326-6066.c.6548600.v1
https://doi.org/10.1158/2326-6066.c.6548600.v1
Autor:
Thomas A. Waldmann, Bonita R. Bryant, Nancy Beltran, Jennifer Hsu-Albert, Jürgen R. Müller, Kevin C. Conlon, Sigrid Dubois
Representation of surface marker analyses on gated NK cells with constant expressions before and after IL-15 infusions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdc1cd49cc7790d41109f4a3ccb1b81
https://doi.org/10.1158/2326-6066.22537907
https://doi.org/10.1158/2326-6066.22537907
Autor:
Thomas A. Waldmann, Bonita R. Bryant, Nancy Beltran, Jennifer Hsu-Albert, Jürgen R. Müller, Kevin C. Conlon, Sigrid Dubois
antibody table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f792e6e715293c4dc35925ec030ad9b
https://doi.org/10.1158/2326-6066.22537898.v1
https://doi.org/10.1158/2326-6066.22537898.v1
Autor:
Thomas A. Waldmann, Mario Roederer, Stephen P. Creekmore, Jason L. Yovandich, Joanna H. Shih, Cody J. Peer, William D. Figg, Jennifer Hsu, Liyanage P. Perera, Michael Petrus, Bonita R. Bryant, Sigrid Dubois, Thomas A. Fleisher, Milos D. Miljkovic, Chyi-Chia Richard Lee, Stefania Pittaluga, E. Lake Potter, Kevin C. Conlon
Supplementary Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1bf1c000cdaa5e45163768f14b90ad
https://doi.org/10.1158/1078-0432.22472925
https://doi.org/10.1158/1078-0432.22472925
Autor:
Thomas A. Waldmann, Mario Roederer, Stephen P. Creekmore, Jason L. Yovandich, Joanna H. Shih, Cody J. Peer, William D. Figg, Jennifer Hsu, Liyanage P. Perera, Michael Petrus, Bonita R. Bryant, Sigrid Dubois, Thomas A. Fleisher, Milos D. Miljkovic, Chyi-Chia Richard Lee, Stefania Pittaluga, E. Lake Potter, Kevin C. Conlon
Supplementary Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7ee296ed768898d0927feed11daee
https://doi.org/10.1158/1078-0432.22472958
https://doi.org/10.1158/1078-0432.22472958
Autor:
Thomas A. Waldmann, Mario Roederer, Stephen P. Creekmore, Jason L. Yovandich, Joanna H. Shih, Cody J. Peer, William D. Figg, Jennifer Hsu, Liyanage P. Perera, Michael Petrus, Bonita R. Bryant, Sigrid Dubois, Thomas A. Fleisher, Milos D. Miljkovic, Chyi-Chia Richard Lee, Stefania Pittaluga, E. Lake Potter, Kevin C. Conlon
Supplementary Data (Tracking)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3950620d876ff80b11022940ee60e6c
https://doi.org/10.1158/1078-0432.22472937
https://doi.org/10.1158/1078-0432.22472937
Autor:
Thomas A. Waldmann, Mario Roederer, Stephen P. Creekmore, Jason L. Yovandich, Joanna H. Shih, Cody J. Peer, William D. Figg, Jennifer Hsu, Liyanage P. Perera, Michael Petrus, Bonita R. Bryant, Sigrid Dubois, Thomas A. Fleisher, Milos D. Miljkovic, Chyi-Chia Richard Lee, Stefania Pittaluga, E. Lake Potter, Kevin C. Conlon
Purpose:The first-in-human clinical trial with human bolus intravenous infusion IL15 (rhIL15) was limited by treatment-associated toxicity. Here, we report toxicity, immunomodulation, and clinical activity of rhIL15 administered as a 10-day continuou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c59bd9e44049b887a568fab0a909f2
https://doi.org/10.1158/1078-0432.c.6528375
https://doi.org/10.1158/1078-0432.c.6528375
Autor:
Yandan Yang, Sigrid Dubois, Takashi Ishio, Takanori Teshima, Shinya Tanaka, Emmanuel Bachy, Masao Nakagawa, Satoshi Hashino, Yibin Yang, Sarvesh Kumar, Yutaka Hatanaka, Anusara Daenthanasanmak, Joji Shimono, Tomoyuki Endo, Patrick L. Green, Bonita R. Bryant, Yoshihiro Matsuno, Michiyuki Maeda, Hiroo Hasegawa, Da-Wei Huang, Michael N. Petrus, Thomas A. Waldmann, Yuquan Lin, Takashi Yokota, Hideki Goto, Kanako C. Hatanaka, Louis M. Staudt
Publikováno v:
Blood. 139:1541-1556
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy with a poor prognosis with current therapy. Here we report genome-wide CRISPR-Cas9 screening of ATLL models, which identified CDK6, CCND2, BATF3, JUNB, STAT3, and IL10RB as gene
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102793 (2014)
NK cells are able to form a functional memory suggesting that some NK cells are surviving the activation process. We hypothesized that NK cell activation causes the development of a distinct NK cell subset and studied the fate of murine post-activati
Externí odkaz:
https://doaj.org/article/73ba523ff0ff483a80167310b8726d3e