Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sigourney Bell"'
Autor:
Molly A. Taylor, Adina M. Hughes, Josephine Walton, Anna M. L. Coenen-Stass, Lukasz Magiera, Lorraine Mooney, Sigourney Bell, Anna D. Staniszewska, Linda C. Sandin, Simon T. Barry, Amanda Watkins, Larissa S. Carnevalli, Elizabeth L. Hardaker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background The ability to modulate immune-inhibitory pathways using checkpoint blockade antibodies such as αPD-1, αPD-L1, and αCTLA-4 represents a significant breakthrough in cancer therapy in recent years. This has driven interest in ide
Externí odkaz:
https://doaj.org/article/fdf87854fdd843649e405bcb762d5816
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Primers used for targeted gene profiling on selected RAS/MAPK pathway genes either on Fluidigm or by qRT-PCR on Roche Lightcycler 480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be1d38b84bbeb9fe19955e7de25d2b
https://doi.org/10.1158/1535-7163.22521541
https://doi.org/10.1158/1535-7163.22521541
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8cb1ae292b59622591433bfe72565e
https://doi.org/10.1158/1535-7163.22521556
https://doi.org/10.1158/1535-7163.22521556
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d656816b18c3ad9cb8c303b7ebd7f0b
https://doi.org/10.1158/1535-7163.22521559
https://doi.org/10.1158/1535-7163.22521559
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
KRAS mutation status of cell lines included in in vitro combination screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2948856a623204b2bfff5869f7d00b5e
https://doi.org/10.1158/1535-7163.22521529.v1
https://doi.org/10.1158/1535-7163.22521529.v1
Autor:
Simon T. Barry, Stephen E. Fawell, Teresa Klinowska, Susan E. Critchlow, Cristina Gardelli, Pablo Morentin Gutierrez, Michele Moschetta, Maneesh Singh, Danielle Carroll, Neha Wali, Antonio Ramos-Montoya, Yanjun Wang, Theresa A. Proia, Sigourney Bell, Adina M. Hughes, Anna M.L. Coenen-Stass, Matthew King, Molly A. Taylor, Larissa S. Carnevalli
Suppressive myeloid cells mediate resistance to immune checkpoint blockade. PI3Kγ inhibition can target suppressive macrophages, and enhance efficacy of immune checkpoint inhibitors. However, how PI3Kγ inhibitors function in different tumor microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5db27890affeab7375808ed1468dea
https://doi.org/10.1158/1535-7163.c.6543334
https://doi.org/10.1158/1535-7163.c.6543334
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
The RAS-regulated RAF–MEK1/2–ERK1/2 (RAS/MAPK) signaling pathway is a major driver in oncogenesis and is frequently dysregulated in human cancers, primarily by mutations in BRAF or RAS genes. The clinical benefit of inhibitors of this pathway as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdb35b33664ffcfa90648d650a5e76d
https://doi.org/10.1158/1535-7163.c.6543055.v1
https://doi.org/10.1158/1535-7163.c.6543055.v1
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f46c618c3a5211c6970b472f7e487f
https://doi.org/10.1158/1535-7163.22521547
https://doi.org/10.1158/1535-7163.22521547
Autor:
Simon T. Barry, Stephen E. Fawell, Teresa Klinowska, Susan E. Critchlow, Cristina Gardelli, Pablo Morentin Gutierrez, Michele Moschetta, Maneesh Singh, Danielle Carroll, Neha Wali, Antonio Ramos-Montoya, Yanjun Wang, Theresa A. Proia, Sigourney Bell, Adina M. Hughes, Anna M.L. Coenen-Stass, Matthew King, Molly A. Taylor, Larissa S. Carnevalli
Supplementary Figure 1. Pharmacokinetic (PK) properties of AZD3458 in mouse. Supplementary Figure 2. In vivo pharmacodynamic properties of AZD3458 in mouse neutrophils. Supp Fig 3. PI3K-�/mTOR pathway regulates expression of IL-10/IL-12 via LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948d7693e031fd14364c926a362ec350
https://doi.org/10.1158/1535-7163.22522333.v1
https://doi.org/10.1158/1535-7163.22522333.v1
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5b82dd79cbfd859f34b41f858212fb
https://doi.org/10.1158/1535-7163.22521526.v1
https://doi.org/10.1158/1535-7163.22521526.v1