Inhibition of patched drug efflux increases vemurafenib effectiveness against resistant braf(V600E) melanoma

Autor: Signetti, Laurie, Elizarov, Nelli, Simsir, Méliné, Paquet, Agnès, Douguet, Dominique, Labbal, Fabien, Debayle, Delphine, Di Giorgio, Audrey, Biou, Valérie, Girard, Christophe, Duca, Maria, Bretillon, Lionel, Bertolotto, Corine, Verrier, Bernard, Azoulay, Stéphane, Mus-Veteau, Isabelle

Publikováno v: Cancers
Cancers, MDPI, 2020, 12 (6), pp.1500. ⟨10.3390/cancers12061500⟩
Volume 12
Issue 6
Cancers, 2020, 12 (6), pp.1500. ⟨10.3390/cancers12061500⟩
Cancers, Vol 12, Iss 1500, p 1500 (2020)

Melanoma patients harboring the BRAFV600E mutation are treated with vemurafenib. Almost all of them ultimately acquire resistance, leading to disease progression. Here, we find that a small molecule from a marine sponge, panicein A hydroquinone (PAH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2cc3339fd7338355a1b8f8d81e9ed07b
https://hal.inrae.fr/hal-02884136

Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo

Autor: Hasanovic, Anida, Ruggiero, Carmen, Jung, Sara, Rapa, Ida, Signetti, Laurie, Ben Hadj, Monia, Terzolo, Massimo, Beuschlein, Felix, Volante, Marco, Hantel, Constanze, Lalli, Enzo, Mus-Veteau, Isabelle

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2018, 143 (1), pp.199-211. ⟨10.1002/ijc.31296⟩

One of the crucial challenges in the clinical management of cancer is the resistance to chemotherapeutics. We recently demonstrated that the Hedgehog receptor Patched, which is overexpressed in many recurrent and metastatic cancers, is a multidrug tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::45ba9fb2124f85d8a761ffcbce781fbc
https://www.zora.uzh.ch/id/eprint/149141/

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Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo.

Autor: Hasanovic, Anida, Ruggiero, Carmen, Jung, Sara, Rapa, Ida, Signetti, Laurie, Ben Hadj, Monia, Terzolo, Massimo, Beuschlein, Felix, Volante, Marco, Hantel, Constanze, Lalli, Enzo, Mus‐Veteau, Isabelle

Publikováno v: International Journal of Cancer; Jul2018, Vol. 143 Issue 1, p199-211, 13p

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