Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Signe Stensen"'
Autor:
Signe Stensen, Liva L. Krogh, Alexander H. Sparre‐Ulrich, Flemming Dela, Bolette Hartmann, Tina Vilsbøll, Jens J. Holst, Mette M. Rosenkilde, Mikkel B. Christensen, Lærke S. Gasbjerg, Filip K. Knop
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1882-1887
Autor:
Liva S L Krogh, Kristine Henriksen, Signe Stensen, Kirsa Skov-Jeppesen, Natasha C Bergmann, Joachim Størling, Mette M Rosenkilde, Bolette Hartmann, Jens J Holst, Lærke S Gasbjerg, Filip K Knop
Publikováno v:
European Journal of Endocrinology. 188
ObjectiveThe gut hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of glucose and bone metabolism. In rodents, the naturally occurring GIP variant, GIP(1-30)NH2, has shown similar effects as full-length GIP (GIP(1-4
Autor:
Bolette Hartmann, Liva S.L. Krogh, Filip K. Knop, Mette M. Rosenkilde, Alexander Hovard Sparre-Ulrich, Tina Vilsbøll, Kirsa Skov-Jeppesen, Jens J. Holst, Mette H. Jensen, Mikkel B. Christensen, Flemming Dela, Lærke S. Gasbjerg, Signe Stensen
Publikováno v:
Stensen, S, Gasbjerg, L S, Krogh, L L, Skov-Jeppesen, K, Sparre-Ulrich, A H, Jensen, M H, Dela, F, Hartmann, B, Vilsbøll, T, Holst, J J, Rosenkilde, M M, Christensen, M B & Knop, F K 2021, ' Effects of endogenous GIP in patients with type 2 diabetes ', European Journal of Endocrinology, vol. 185, no. 1, pp. 33-45 . https://doi.org/10.1530/EJE-21-0135
Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabo
Autor:
LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, LIVA S.L. KROGH, ALEXANDER H. SPARRE-ULRICH, BOLETTE HARTMANN, TINA VILSBØLL, MIKKEL B. CHRISTENSEN, JENS J. HOLST, CHRISTINA CHRISTOFFERSEN, FILIP K. KNOP, METTE M. ROSENKILDE
Publikováno v:
Diabetes. 71
The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates glucose-induced insulin secretion and increases triglyceride deposition in subcutaneous adipose tissue, and these effects are attenuated in both type 2 diabetes (T2D) and o
Autor:
BJØRN HOE, MADS B. LYNGGAARD, LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, BOLETTE HARTMANN, JENS J. HOLST, MIKKEL B. CHRISTENSEN, TINA VILSBØLL, FILIP K. KNOP
Publikováno v:
Diabetes. 71
The insulinotropic effect of exogenous glucose-dependent insulinotropic polypeptide (GIP) is severely reduced or even absent in persons with type 2 diabetes but may be partly regained following improved glycemic control. Here, we examined the beta ce
Autor:
Amalie R. Lanng, David S. Mathiesen, Mikkel B. Christensen, Mette M. Rosenkilde, Lærke S. Gasbjerg, Filip K. Knop, Signe Stensen, Emilie Johanning Bari, Bjørn Hoe, Bolette Hartmann, Jens J. Holst
Publikováno v:
Diabetes, Obesity and Metabolism. 23:68-74
The glucose-dependent insulinotropic polypeptide (GIP) fragment GIP(3-30)NH2 is a selective, competitive GIP receptor antagonist, and doses of 800 to 1200 pmol/kg/min inhibit GIP-induced potentiation of glucose-stimulated insulin secretion by >80% in
Autor:
Signe Stensen, Lærke S. Gasbjerg, Mette M. Rosenkilde, Tina Vilsbøll, Jens J. Holst, Bolette Hartmann, Mikkel B. Christensen, Filip K. Knop
Publikováno v:
Diabetes. 71(10)
Dipeptidyl peptidase 4 (DPP-4) degrades the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). DPP-4 inhibitors improve glycemic control in type 2 diabetes, but the importance of protecting GIP f
Autor:
Tina Vilsbøll, Mikkel B. Christensen, Jens J. Holst, Mette M. Rosenkilde, Filip K. Knop, Lærke S. Gasbjerg, Bolette Hartmann, Signe Stensen
Publikováno v:
Diabetes. 70
In persons with type 2 diabetes (T2D), dipeptidyl peptidase 4 (DPP-4) inhibitor treatment improves glycemic control by raising the active levels of the insulinotropic gut hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypepti
Autor:
Lærke S. Gasbjerg, Mette M. Rosenkilde, Amalie R. Lanng, Natasha C. Bergmann, Mikkel B. Christensen, Mads M. Helsted, Jens J. Holst, Maria Buur Nordskov Gabe, Tina Vilsbøll, Simon Veedfald, Bolette Hartmann, Alexander Hovard Sparre-Ulrich, Mette H. Jensen, Filip K. Knop, Signe Stensen
Publikováno v:
Diabetes. 68:906-917
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted postprandially and contribute importantly to postprandial glucose tolerance. In this study, we assessed the individual and combi
Autor:
Signe Stensen, Tina Vilsbøll, Bolette Hartmann, Jens F. Rehfeld, Filip K. Knop, Niels B. Dalsgaard, Laura S. Hansen, Nina L. Hansen, Lærke S. Gasbjerg, Jens J. Holst
Publikováno v:
European journal of endocrinology. 184(3)
Aims The alpha-glucosidase inhibitor acarbose is believed to reduce plasma glucose by delaying hydrolysis of carbohydrates. Acarbose-induced transfer of carbohydrates to the distal parts of the intestine increases circulating glucagon-like peptide 1