HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation

Autor: Krzysztof Wrzesinski, Maria Bobadilla, Stephen J. Fey, Tobias Bergauer, Line Visby Hansen, Signe Marie Andersen, Kira Joensen, Jacques Mizrahi, Marcel Gubler, Ove B. Schaffalitzky de Muckadell, Jacob Bastholm Olesen, Christina Møller Andreasen, Kelan Zhang, Maria Chiara Magnone, Marianne Ehrhorn Kruse

Publikováno v: Wrzesinski, K, Magnone, M C, Hansen, L V, Ehrhorn Kruse, M, Bergauer, T, Bobadilla, M, Gubler, M, Mizrahi, J, Zhang, K, Andreasen, C M, Joensen, K, Andersen, S M, Olesen, J B, Schaffalitzky de Muckadell, O B & Fey, S J 2013, ' HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation ', Toxicology Research, vol. 2, no. 3, pp. 163-172 . https://doi.org/10.1039/c3tx20086h

Primary human hepatocytes are widely used as an in vitro system for the assessment of drug metabolism and toxicity. Nevertheless a cell system with higher stability of physiological functions is required for the investigation of drugs’ mode of acti

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