Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Signe M. Christensen"'
Publikováno v:
Organic Process Research & Development. 8:777-780
Two variants of oxidation with DMSO followed by sodium borohydride reduction have been investigated to make the synthesis of 1,2:5,6-di-O-isopropylidene-α-d-allofuranose (4) suitable for large-scale manufacturing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e791863d6cfc3132d9ec0534d2058c9f
https://doi.org/10.1021/op049903t
https://doi.org/10.1021/op049903t
Autor:
Mads D. Sørensen, Troels Koch, Lotte-Emilie Larsen, Daniel Sejer Pedersen, Jesper Wengel, Signe M. Christensen, Christoph Rosenbohm
Publikováno v:
Organic & Biomolecular Chemistry. 1:655-663
In this paper we present revised and significantly improved synthetic routes to 2′-amino-LNA (locked nucleic acid). The optimal route is convergent with the synthesis of LNA monomers (“2′-oxy-LNA”) via a common intermediate obtained by a mild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9554b482056cc1f061c269843c2305
https://doi.org/10.1039/b208864a
https://doi.org/10.1039/b208864a
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 25(8)
The first reported synthesis of 2′-amino-LNA purine nucleosides via a transnucleosidation is accomplished enabling the preparation of oligonucleotides incorporating 2′-amino-LNA with all four natural bases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cccd3f5ad7b18b16a289a3735e6ef0d
https://pubmed.ncbi.nlm.nih.gov/16901815
https://pubmed.ncbi.nlm.nih.gov/16901815
Autor:
Christoph Rosenbohm, Signe M. Christensen, Troels Koch, Marit B. de Wissel, Henrik Ørum, Jeroen P. Vreijling, Frank Baas, Miriam Frieden, Kees Fluiter
Publikováno v:
Chembiochem, 6(6), 1104-1109. Wiley-VCH Verlag
Locked nucleic acid (beta-D-LNA) monomers are conformationally restricted nucleotides bearing a methylene 2'-O, 4'-C linkage that have an unprecedented high affinity for matching DNA or RNA. In this study, we compared the in vitro and in vivo propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22884fce5469fed7fd0c78fbf5659aaf
https://pure.amc.nl/en/publications/on-the-in-vitro-and-in-vivo-properties-of-four-locked-nucleic-acid-nucleotides-incorporated-into-an-antihras-antisense-oligonucleotide(8529b47b-5f81-4e8e-bad6-65e1312dc4c1).html
https://pure.amc.nl/en/publications/on-the-in-vitro-and-in-vivo-properties-of-four-locked-nucleic-acid-nucleotides-incorporated-into-an-antihras-antisense-oligonucleotide(8529b47b-5f81-4e8e-bad6-65e1312dc4c1).html
Autor:
Lotte-Emilie Larsen, Christoph Rosenbohm, Mads Sølvsten Sørensen, Troels Koch, Signe M. Christensen, Jesper Wengel
Publikováno v:
Christensen, S M, Rosenbohm, C, Sørensen, M, Larsen, L-E, Wengel, J & Koch, T 2003, ' Improved Synthesis of 2'-Amino-LNA ', Nucleosides, Nucleotides and Nucleic Acids, vol. 22, no. 5-8, pp. 1131-1133 . https://doi.org/10.1081/NCN-120022818
2′-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2′-oxy-LNA up until a late stage intermediate (1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e2abc1237a3beca82d4298da71f0a7
https://doi.org/10.1002/chin.200406202
https://doi.org/10.1002/chin.200406202
Autor:
Majken Westergaard, Henrik Frydenlund Hansen, Nikolaj Dam Mikkelsen, Christoph Rosenbohm, Signe M. Christensen, Troels Koch, Miriam Frieden, Henrik Ørum, Charlotte Albaek Thrue
Publikováno v:
Nucleic acids research. 31(21)
Oligonucleotides containing Locked Nucleic Acids (LNA) to various extents and at various positions were evaluated for antisense activity, RNase H recruitment, nuclease stability and thermal affinity. In this work, two different diastereoisomers of LN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83656d73e12547287c6c04be48c38a8
https://pubmed.ncbi.nlm.nih.gov/14576324
https://pubmed.ncbi.nlm.nih.gov/14576324
Autor:
Christoph, Rosenbohm, Signe M, Christensen, Mads D, Sørensen, Daniel Sejer, Pedersen, Lotte-Emilie, Larsen, Jesper, Wengel, Troels, Koch
Publikováno v:
Organicbiomolecular chemistry. 1(4)
In this paper we present revised and significantly improved synthetic routes to 2'-amino-LNA (locked nucleic acid). The optimal route is convergent with the synthesis of LNA monomers ("2'-oxy-LNA") via a common intermediate obtained by a mild deacety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1e2d6b0d492ecb33253c5ccb0287d02
https://pubmed.ncbi.nlm.nih.gov/12929452
https://pubmed.ncbi.nlm.nih.gov/12929452