Supplementary Tables S1-S8 and Figures S1-S3 from DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

Autor: Eva Budinska, Nils Brünner, Mauro Delorenzi, Arnaud Roth, Sabine Tejpar, Fred Bosman, Signe Lykke Nielsen, Ben Vainer, Sune Boris Nygård

Supplementary Table S1: Baseline characteristics of biomarker stage III vs PETACC3 stage III. Supplementary Table S2: Baseline characteristics of biomarker stage II + III vs PETACC3 stage II + III. Supplementary Table S3: Treatment effects in the bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b83afb2ddc2723c5c6843380d82f41
https://doi.org/10.1158/1078-0432.22458354

New use for old drugs: Epirubicin in colorectal cancer

Autor: Camilla Qvortrup, Line Schmidt Tarpgaard, Per Pfeiffer, Nils Brünner, Sönke Detlefsen, Signe Lykke Nielsen, Jan Stenvang

Publikováno v: Tarpgaard, L S, Qvortrup, C, Nielsen, S L, Stenvang, J, Detlefsen, S, Brünner, N & Pfeiffer, P 2021, ' New use for old drugs : Epirubicin in colorectal cancer ', Acta Oncologica, vol. 60, no. 7, pp. 954-956 . https://doi.org/10.1080/0284186X.2021.1904519

We have previously published an article describing the protocol for a clinical, non-randomized phase II study (Eudract no. 2013-001648-79) [1], which aimed to provide proof of concept for introduci...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a8c8cd154206a435e93caed3da6c5
https://doi.org/10.1080/0284186x.2021.1904519

Expression Patterns of Biomarkers in Primary Tumors and Corresponding Metastases in Breast Cancer

Autor: Iben Kümler, Sofie S. Jespersen, Nils Brünner, Ann S. Knop, Signe Lykke Nielsen, Dorte Nielsen, Tobias Wirenfeldt Klausen, Eva Balslev

Publikováno v: Applied immunohistochemistrymolecular morphology : AIMM. 26(1)

Tumor heterogeneity has been shown for several cancers including breast cancer (BC). Despite the fact that expression of tumor markers may change throughout the metastatic process, rebiopsies at the time of recurrence are still not performed routinel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c67959fcf4779d8a9eee300ec35465
https://pubmed.ncbi.nlm.nih.gov/27753656

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

Autor: Nils Brünner, Anne-Sofie Schrohl, Yves Pommier, Petra Hamerlik, Magnus Stougaard, John A. Foekens, Birgitta R. Knudsen, Signe Lykke Nielsen, José M.A. Moreira, Marcel Smid, Kristina Aluzaite, Stine Ninel Hansen, John W.M. Martens, Madhavsai K. Gajjar, Julie B. Noer, Britt Damsgaard, Haatisha Jandu, Louise Fogh, Khoa Nguyen Do, Jan Stenvang, Joanna Proszek, Sebastian Wingaard Thrane

Publikováno v: Jandu, H, Aluzaite, K, Fogh, L, Thrane, S W, Noer, J B, Proszek, J, Do, K N, Hansen, S N, Damsgaard, B, Nielsen, S L, Stougaard, M, Knudsen, B R, Moreira, J, Hamerlik, P, Gajjar, M, Smid, M, Martens, J, Foekens, J, Pommier, Y, Brünner, N, Schrohl, A-S & Stenvang, J 2016, ' Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines ', BMC Cancer, vol. 16, no. 1, 34 . https://doi.org/10.1186/s12885-016-2071-1
BMC Cancer
Jandu, H, Aluzaite, K, Fogh, L, Thrane, S W, Noer, J B, Proszek, J, Nguyen Do, K, Hansen, S N, Damsgaard, B, Nielsen, S L, Stougaard, M, Knudsen, B R, Moreira, J, Hamerlik, P, Gajjar, M, Smid, M, Martens, J, Foekens, J, Pommier, Y, Brunner, N, Schrohl, A-S & Stenvang, J 2016, ' Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines ', B M C Cancer, vol. 16, no. 1, 34 . https://doi.org/10.1186/s12885-016-2071-1
BMC Cancer, 16:34. BioMed Central Ltd.

Background Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30 % response rates to irinotecan. Hence, a significant number of patients will experience irinotecan-induced side effects w

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https://doi.org/10.1186/s12885-016-2071-1

TOP1gene copy numbers in colorectal cancer samples and cell lines and their association toin vitrodrug sensitivity

Autor: Nils Brünner, Signe Lykke Nielsen, Kirsten Vang Nielsen, Maria Unni Rømer, Niels Frank Jensen, Hans Jørgen Nielsen, Sven Müller

Publikováno v: Scandinavian Journal of Gastroenterology. 47:68-79

A positive relationship between topoisomerase-1 (TOP1) protein and sensitivity toward the TOP1 inhibitor irinotecan has been reported in patients with metastatic colorectal cancer (mCRC). In this study, we analyzed TOP1 gene copy number variation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b15f6a6b80862e69c59627e9914c618
https://doi.org/10.3109/00365521.2011.638393