Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Signe, Mathiasen"'
Autor:
Michael D. Holsey, Grant T. Gilmore, Adam W. Smith, Jonathan A. Javitch, Avik Kumar Pati, Kaleeckal G. Harikumar, Zhou Zhou, Jozsef Meszaros, Laurence J. Miller, Khuloud Jaqaman, Peter Geggier, Signe Mathiasen, Wesley B. Asher, Megan J. Kaliszewski, Mitchell D. McCauley, Scott C. Blanchard, Daniel S. Terry, Alekhya Govindaraju
Publikováno v:
Nature Methods. 18:397-405
Class C G protein-coupled receptors (GPCRs) are known to form stable homodimers or heterodimers critical for function, but the oligomeric status of class A and B receptors, which constitute >90% of all GPCRs, remains hotly debated. Single-molecule fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1d5af5024e5772f7bfbd0e90f26b66
https://doi.org/10.1038/s41592-021-01081-y
https://doi.org/10.1038/s41592-021-01081-y
Autor:
Kouki Kawakami, Jonathan A. Javitch, Michel Bouvier, Sumin Lu, Najeah Okashah, Joris Zhou, Signe Mathiasen, Nevin A. Lambert, Asuka Inoue, Shane C. Wright
Publikováno v:
Proceedings of the National Academy of Sciences. 117:21723-21730
G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5426e5872542dade491fd380feba8fb2
https://doi.org/10.1073/pnas.2003787117
https://doi.org/10.1073/pnas.2003787117
Autor:
Alex Vizurraga, Tiago Palmisano, Gregory G. Tall, Dyke P. McEwen, Nevin A. Lambert, Hannah M. Stoveken, Jonathan A. Javitch, Asuka Inoue, Nicole A. Perry, Najeah Okashah, Tobias Langenhan, Signe Mathiasen
Publikováno v:
Nature Chemical Biology. 16:1343-1350
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ab0b8187597f30172c434e1adeaa9a
https://doi.org/10.1038/s41589-020-0617-7
https://doi.org/10.1038/s41589-020-0617-7
Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter
Autor:
Alessandro Bonifazi, Amy Hauck Newman, Therese Ku, Signe Mathiasen, Matthew D. Lycas, Jonathan B. Grimm, Daryl A. Guthrie, Brian T. DeVree, Carmen Klein Herenbrink, Jonathan A. Javitch, Ulrik Gether, Luke D. Lavis
Publikováno v:
ACS Chem Neurosci
The dopamine transporter (DAT) is critical for spatiotemporal control of dopaminergic neurotransmission and the target for therapeutic agents, including ADHD medications, and abused substances, such as cocaine. Here, we develop new fluorescently labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a53ec11b73ce601a19b494e93bb2a9
https://pubmed.ncbi.nlm.nih.gov/32926777
https://pubmed.ncbi.nlm.nih.gov/32926777
Autor:
Najeah, Okashah, Shane C, Wright, Kouki, Kawakami, Signe, Mathiasen, Joris, Zhou, Sumin, Lu, Jonathan A, Javitch, Asuka, Inoue, Michel, Bouvier, Nevin A, Lambert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance G protein-coupled receptors (GPCRs) are targeted by a large fraction of approved drugs and regulate many important cellular processes. Association of GPCRs with heterotrimeric G proteins in response to agonist activation is thought to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bff68d7694cf8fbe10b8c911a1e6d72a
https://pubmed.ncbi.nlm.nih.gov/32817560
https://pubmed.ncbi.nlm.nih.gov/32817560
Autor:
Wesley B, Asher, Peter, Geggier, Michael D, Holsey, Grant T, Gilmore, Avik K, Pati, Jozsef, Meszaros, Daniel S, Terry, Signe, Mathiasen, Megan J, Kaliszewski, Mitchell D, McCauley, Alekhya, Govindaraju, Zhou, Zhou, Kaleeckal G, Harikumar, Khuloud, Jaqaman, Laurence J, Miller, Adam W, Smith, Scott C, Blanchard, Jonathan A, Javitch
Publikováno v:
Nature methods. 18(4)
Class C G protein-coupled receptors (GPCRs) are known to form stable homodimers or heterodimers critical for function, but the oligomeric status of class A and B receptors, which constitute90% of all GPCRs, remains hotly debated. Single-molecule fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7f333d5b4d4c15d36b008483cec173d
https://pubmed.ncbi.nlm.nih.gov/33686302
https://pubmed.ncbi.nlm.nih.gov/33686302
Autor:
Daniel Hilger, Brian K. Kobilka, Signe Mathiasen, Maria Hauge, Matthieu Masureel, Scott C. Blanchard, Harel Weinstein, Jonathan A. Javitch, G. Glenn Gregorio, Daniel S. Terry, Jose Manuel Perez-Aguilar, Zhou Zhou, Hong Zhao, Manuel F. Juette
Publikováno v:
Nature
SUMMARY G protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signaling responses remain poorly understood. In Class A GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363ac570ebe4397bdf87806c5d92aeae
https://doi.org/10.1038/nature22354
https://doi.org/10.1038/nature22354
Autor:
Wesley B. Asher, Steffen Jockusch, Hong Zhao, Zhou Zhou, Qinsi Zheng, Signe Mathiasen, Scott C. Blanchard, Peter Geggier, Roger B. Altman, Michael D. Holsey, Jonathan A. Javitch
Publikováno v:
Chemical Science. 8:755-762
Bright, long-lasting organic fluorophores enable a broad range of imaging applications. “Self-healing” fluorophores, in which intra-molecularly linked protective agents quench photo-induced reactive species, exhibit both enhanced photostability a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f13a4841343e6c492e7b59ceaddf4f8
https://doi.org/10.1039/c6sc02976k
https://doi.org/10.1039/c6sc02976k
Autor:
Signe, Mathiasen, Tiago, Palmisano, Nicole A, Perry, Hannah M, Stoveken, Alex, Vizurraga, Dyke P, McEwen, Najeah, Okashah, Tobias, Langenhan, Asuka, Inoue, Nevin A, Lambert, Gregory G, Tall, Jonathan A, Javitch
Publikováno v:
Nature chemical biology. 16(12)
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c61cfbef5e6773a13ef80399497a6a8
https://pubmed.ncbi.nlm.nih.gov/32989302
https://pubmed.ncbi.nlm.nih.gov/32989302
Autor:
Gregory G. Tall, Najeah Okashah, Alex Vizurraga, Tiago Palmisano, Dyke P. McEwen, Nevin A. Lambert, Asuka Inoue, Jonathan A. Javitch, Nicole A. Perry, Tobias Langenhan, Signe Mathiasen, Hannah M. Stoveken
Publikováno v:
Nature Chemical Biology. 16:1440-1440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65359d32ab4ea2b388e854c92a1bb87f
https://doi.org/10.1038/s41589-020-0649-z
https://doi.org/10.1038/s41589-020-0649-z