Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Signal Initiation"'
Autor:
Simon Alamos, Donald Hansen, Hernan G. Garcia, Elizabeth Eck, Jonathan Liu, Yang Joon Kim, Meghan A Turner
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008999 (2021)
PLoS Computational Biology
PLoS Computational Biology
The eukaryotic transcription cycle consists of three main steps: initiation, elongation, and cleavage of the nascent RNA transcript. Although each of these steps can be regulated as well as coupled with each other, their in vivo dissection has remain
Autor:
Gary Struhl, Myriam Zecca
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001111 (2021)
PLoS Biology
PLoS Biology
Development of the Drosophila wing—a paradigm of organ development—is governed by 2 morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (Wg, a Wnt). Both proteins are produced by defined subpopulations of cells and spread outwards, forming grad
Autor:
Amin Cheikhi, Cecelia C. Yates, Dana R. Julian, Carol Feghali-Bostwick, Zariel I. Johnson, Yvette P. Conley, James Lyons-Weiler, Sarah E Wheeler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240986 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240986 (2020)
Fibrosis is a chronic disease with heterogeneous clinical presentation, rate of progression, and occurrence of comorbidities. Systemic sclerosis (scleroderma, SSc) is a rare rheumatic autoimmune disease that encompasses several aspects of fibrosis, i
Publikováno v:
PLoS ONE
The goal of cancer chemotherapy to induce multi-directional apoptosis as targeting a single pathway is unable to decrease all the downstream effect arises from crosstalk. Present study reports that Withanolide D (WithaD), a steroidal lactone isolated
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Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000498 (2019)
PLoS Biology
PLoS Biology
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of research in the mouse embryo have revealed that a signaling cascade involving t
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007548 (2019)
PLoS Pathogens
PLoS Pathogens
Autor:
John A. Foekens, Agnes Jager, John W.M. Martens, Anouk A. J. Heine, Marijn T.M. van Jaarsveld, Erik A.C. Wiemer, Wendy J. C. Prager-van der Smissen, Antonius W. M. Boersma, Bahar Ozturk, Marcel Smid, Katharina Uhr
Publikováno v:
PLoS ONE
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited number of relatively small scale studies comprising few cell lines
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231343 (2020)
PLoS ONE
PLoS ONE
Acoustic signaling plays an important role in mother-offspring recognition and subsequent bond-formation. It remains unclear, however, if mothers and offspring use acoustic signaling in the same ways and for the same reasons throughout the juvenile s
Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells
Autor:
Björn Tampe, Gunsmaa Nyamsuren, Xingbo Xu, Maja Životić, Müller Ca, Aleksandar Lipkovski, Gerhard A. Müller, Jasmina Markovic-Lipkovski, Michael Zeisberg
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206786 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206786 (2018)
Neural cell adhesion molecule (NCAM) and fibroblast growth factor receptor 1 (FGFR1) cross-talk have been involved in epithelial-to-mesenchymal transition (EMT) process during carcinogenesis. Since EMT also contributes to maladaptive repair and paren