Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sigmund J. Degitz"'
Autor:
Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz
Publikováno v:
Toxicol Sci
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical
Autor:
Jonathan T. Haselman, John W. Nichols, Kali Z. Mattingly, Michael W. Hornung, Sigmund J. Degitz
Publikováno v:
Mathematical Biosciences. :109021
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Autor:
Jennifer H. Olker, Joseph J. Korte, Jonathan T. Haselman, Michael W. Hornung, Sigmund J. Degitz
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 249
The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical di
Autor:
Joseph J. Korte, Sigmund J. Degitz, Phillip C. Hartig, Jessica P Christensen, Jennifer H Olker, Paige M Kent, Carsten Knutsen, Mary C. Cardon, Michael W. Hornung, Jeffrey S. Denny
Publikováno v:
Toxicological Sciences. 168:430-442
Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical
Autor:
Brett R. Blackwell, Cody W. Simmons, Antony Williams, Joe Swintek, Daniel L. Villeneuve, Sigmund J. Degitz, Thomas R. Transue, Jon A. Doering, Carlie A. LaLone, Gerald T. Ankley
Publikováno v:
Environ Sci Technol
High-throughput screening (HTS) and computational technologies have emerged as important tools for chemical hazard identification. The US Environmental Protection Agency (EPA) launched the Toxicity ForeCaster (ToxCast™) Program, which has screened
Autor:
Sigmund J. Degitz, Jennifer H Olker, Phillip C. Hartig, Mary C. Cardon, Jonathan T. Haselman, Joseph J. Korte, Jeffrey S. Denny, Michael W. Hornung
Publikováno v:
Toxicol In Vitro
The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption. This highly conserved enzyme plays an essential role in maintaining
Autor:
Joseph J. Korte, Jonathan T. Haselman, Patricia A. Kosian, Sigmund J. Degitz, Allen W. Olmstead
Publikováno v:
Aquatic Toxicology. 199:240-251
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of chronic exposure to an antiandrogenic
Autor:
Joseph J. Korte, Sally A. Mayasich, Phillip C. Hartig, Michael W. Hornung, Jennifer H Olker, Joseph O’Flanagan, Sigmund J. Degitz, Jeffrey S. Denny, Philip DeGoey
Publikováno v:
Toxicol In Vitro
Deiodinase enzymes are critical for tissue-specific and temporal control of activation or inactivation of thyroid hormones during vertebrate development, including amphibian metamorphosis. We previously screened ToxCast chemicals for inhibitory activ
Autor:
Mary E. Gilbert, Sigmund J. Degitz, Jermaine Ford, Patricia A. Kosian, Iman Hassan, Hisham A. El-Masri
Publikováno v:
Toxicological Sciences. 160:57-73
Adequate levels of thyroid hormone (TH) are needed for proper brain development, deficiencies may lead to adverse neurologic outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between