Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Sigmund A. Weitzman"'
Autor:
Paul N. Baer, Sigmund A. Weitzman
Publikováno v:
Journal of periodontology. 56(3)
Autor:
Seok Jo Kim, Vilhelm A. Bohr, Paul T. Schumacker, Karen M. Ridge, Paul Cheresh, Sigmund A. Weitzman, David Williams, David W. Kamp, Yuan Cheng
Publikováno v:
Journal of Biological Chemistry. 289:6165-6176
Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each reduce oxidant-induced alveolar epithelial cell (AEC) apoptosis, but it is unclear whether protection occurs by preventing AEC mitochondrial DNA (mtDNA)
Autor:
Steven Trifilio, C. H. Georgopoulos, Beatrice J. Edwards, J. Lagman, Steven M. Belknap, Sigmund A. Weitzman, Paul R. Yarnold, L. Qualkenbush, Dennis P. West, June M. McKoy
Publikováno v:
The Journal of Clinical Pharmacology. 53:1334-1340
Global introspection is considered an unreliable method for attribution of causality of serious adverse events (SAEs), yet remains widely used for cancer drug clinical trials. Here, we compare structured case abstraction (SCA) to the routine method f
Autor:
Alfred Rademaker, Pooja Loftus, Isabella M. Chu, Bing Bing Weitner, Joseph W. Shega, Jamie H. Von Roenn, Kavitha Ramchandran, Eytan Szmuilowicz, Sigmund A. Weitzman, Mark Schumacher
Publikováno v:
Cancer. 119:2074-2080
BACKGROUND This study sought to develop a predictive model for 30-day mortality in hospitalized cancer patients, by using admission information available through the electronic medical record. METHODS Observational cohort study of 3062 patients admit
Autor:
David W. Kamp, N.C. de Souza-Pinto, S. Surapureddi, Jyothisri Kondapalli, Saul Soberanes, Vijayalakshmi Panduri, Paul T. Schumacker, Vilhelm A. Bohr, G R S. Budinger, Gang Liu, Sigmund A. Weitzman
Publikováno v:
Free Radical Biology and Medicine. 47:750-759
8-Oxoguanine DNA glycosylase (Ogg1) repairs 8-oxo-7,8-dihydroxyguanine (8-oxoG), one of the most abundant DNA adducts caused by oxidative stress. In the mitochondria, Ogg1 is thought to prevent activation of the intrinsic apoptotic pathway in respons
Autor:
Ghata Singhal, Natesan Sankar, Ravi-Kumar Kadeppagari, Bayar Thimmapaya, Sigmund A. Weitzman, Sudhakar Baluchamy
Publikováno v:
Oncogene. 27:5717-5728
We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300
Publikováno v:
Molecular and Cellular Biochemistry. :153-160
Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-derived reactive oxygen species (ROS) is one important mechanism implicated. We previously showed that iron-catalyz
Autor:
David W. Kamp, Sigmund A. Weitzman, Asaad Aljandali, Haunani Pollack, Anjana V. Yeldandi, Yuyu Li
Publikováno v:
Journal of Laboratory and Clinical Medicine. 137:330-339
Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-induced reactive oxygen species (ROS) is one important mechanism. To determine whether asbestos causes apoptosis in
Publikováno v:
Journal of Investigative Medicine. 49:68-76
Background Cigarette smoke augments asbestos-induced bronchogenic carcinoma in a synergistic manner by mechanisms that are not established. One important mechanism may involve alveolar epithelial cell (AEC) injury resulting from oxidant-induced DNA d
Autor:
Bayar Thimmapaya, David Y. Lo, Sigmund A. Weitzman, Kristi A. Miller, Jonathan C.R. Jones, Jean Chung
Publikováno v:
Journal of Biological Chemistry. 275:8176-8182
The transcriptional coactivator p300 is essential for normal embryonic development and cellular differentiation. We have been studying the role of p300 in the transcription of a variety of genes, and we became interested in the role of this coactivat